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Flavestin K, An Isoprenylated Stilbene from the Leaves of Macaranga recurvata Gage

Tjahjandarie TS, Tanjung M, Saputri RD, Nadar PB, Aldin MF, EvaMarliana , Permadi A

A new isoprenylated stilbene, flavestinK (1) together with two known isoprenylated stilbenes, flavestin B (2), flavestin G (3), and two isoprenilated flavanones, 4-O-methyl-8-isoprenylnaringenin (4) and 8-isoprenyl-5,7-dihydroxyflavanone (5) were isolated from...
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Five New Stilbenes from the Stem Bark of Artocarpus communis

Chan ST, Popplewell WL, Bokesch HR, McKee TC, Gustafson

Five new prenylated stilbenes (1 – 5), along with the known compounds cudraflavone C, trans-4-isopentenyl-3,5,2′,4′-terahydroxystilbene, trans-4-(3-methyl-E-but-1-enyl)-3,5,2′,4′-tetrahydroxystilbene, pannokin G, cycloartobiloxanthone, artonin P, morusin, artocarpin, artonin E, kuwanon C, artobiloxanthone, and artoindonesianin...
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Effect of Resveratrol on Oral Cancer Cell Invasion Induced by Lysophosphatidic Acid

Kim JY, Cho KH, Lee HY

The aim of the current study was to demonstrate the potential therapeutic efficacy of resveratrol in oral cancer patients. Lysophosphatidic acid (LPA) intensifies cancer cell invasion and metastasis, whereas resveratrol,...
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Anti-Helicobacter pylori Compounds from Polygonum cuspidatum

Khalil AA, Park WS, Kim HJ, Akter KM, Ahn MJ

Anti-Helicobacter pylori activity guided fractionation led to the isolation of five anthraquinones, two stilbenes and one naphthoquinone from the EtOAc fraction of Polygonum cuspidatum, using silica gel column chromatography, Sephadex-LH20,...
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Resveratrol Inhibits Hypoxia-Induced Vascular Endothelial Growth Factor Expression and Pathological Neovascularization

Lee CS, Choi EY, Lee SC, Koh HJ, Lee JH, Chung JH

PURPOSE: To investigate the effects of resveratrol on the expression of hypoxia-inducible factor 1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) in human adult retinal pigment epithelial (ARPE-19) cells, and...
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Knockdown of Bcl-xL Enhances Growth-Inhibiting and Apoptosis-Inducing Effects of Resveratrol and Clofarabine in Malignant Mesothelioma H-2452 Cells

Lee YJ, Hwang IS, Lee YJ, Lee CH, Kim SH, Nam HS, Choi YJ, Lee SH

Mcl-1 and Bcl-xL, key anti-apoptotic proteins of the Bcl-2 family, have attracted attention as important molecules in the cell survival and drug resistance. In this study, we investigated whether inhibition...
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Effects of resveratrol on the insulin signaling pathway of obese mice

Hong HJ, Kang W, Kim DG, Lee DH, Lee Y, Han CH

The present study was conducted to investigate the effects of resveratrol on the insulin signaling pathway in the liver of obese mice. To accomplish this, we administered resveratrol to high...
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SIRT1 in Type 2 Diabetes: Mechanisms and Therapeutic Potential

Kitada M, Koya D

The prevalence of type 2 diabetes mellitus (T2DM) has been increasing worldwide. Therefore, a novel therapeutic strategy by which to prevent T2DM is urgently required. Calorie restriction (CR) can retard...
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Effects of resveratrol on hepatic autophagy in high fat diet-induced obese mice

Lee HJ, Yang SJ

  • KMID: 2327112
  • J Nutr Health.
  • 2013 Aug;46(4):307-314.
Resveratrol (RSV) exerts several beneficial effects on metabolism and metaflammation-related diseases, including diabetes and non-alcoholic fatty liver disease (NAFLD). The purpose of this study is to investigate whether RSV affects...
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Laxative effect of peanut sprout extract

Seo JY, Kim SS, Kim HJ, Liu KH, Lee HY, Kim JS

  • KMID: 2313678
  • Nutr Res Pract.
  • 2013 Aug;7(4):262-266.
Certain phenolic compounds are known to exhibit laxative properties. Seed sprouts, such as those of peanut, are known to promote de novo biosynthesis of phenolic compounds. This study was conducted...
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Peanut sprout ethanol extract inhibits the adipocyte proliferation, differentiation, and matrix metalloproteinases activities in mouse fibroblast 3T3-L1 preadipocytes

Kim WK, Kang NE, Kim MH, Ha AW

  • KMID: 2313664
  • Nutr Res Pract.
  • 2013 Jun;7(3):160-165.
3T3-L1 preadipocyte were differentiated to adipocytes, and then treated with 0, 10, 20, and 40 microg/mL of peanut sprout ethanol extract (PSEE). The main component of PSEE is resveratrol which...
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Resveratrol Has Anabolic Effects on Disc Degeneration in a Rabbit Model

Kwon YJ

This study was done to evaluate whether injections of resveratrol, a natural compound found in the skin of grapes, had anabolic effects on degenerated intervertebral discs in a rabbit model....
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Resveratrol Inhibits GABAC rho Receptor-Mediated Ion Currents Expressed in Xenopus Oocytes

Lee BH, Choi SH, Hwang SH, Kim HJ, Lee JH, Nah SY

Resveratrol is a phytoalexin found in grapes, red wine, and berries. Resveratrol has been known to have many beneficial health effects, such as anti-cancer, neuroprotective, anti-inflammatory, and life-prolonging effects. However,...
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Expression of DNA Methyltransferases in Breast Cancer Patients and to Analyze the Effect of Natural Compounds on DNA Methyltransferases and Associated Proteins

Mirza S, Sharma G, Parshad R, Gupta SD, Pandya P, Ralhan R

  • KMID: 2374541
  • J Breast Cancer.
  • 2013 Mar;16(1):23-31.
PURPOSE: The DNA methylation mediated by specific DNA methyltransferases (DNMTs), results in the epigenetic silencing of multiple genes which are implicated in human breast cancer. We hypothesized that the natural...
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Resveratrol inhibits the protein expression of transcription factors related adipocyte differentiation and the activity of matrix metalloproteinase in mouse fibroblast 3T3-L1 preadipocytes

Kang NE, Ha AW, Kim JY, Kim WK

  • KMID: 2313634
  • Nutr Res Pract.
  • 2012 Dec;6(6):499-504.
This study attempted to investigate the effects of resveratrol on the differentiation of adipocytes. After cells were treated with various concentrations of resveratrol (0, 10, 20, and 40 micromol/L), adipocyte...
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Antiproliferative and Cytotoxic Effects of Resveratrol in Mitochondria-Mediated Apoptosis in Rat B103 Neuroblastoma Cells

Rahman MA, Kim NH, Kim SH, Oh SM, Huh SO

Resveratrol, a natural compound, has been shown to possess anti-cancer, anti-aging, anti-inflammatory, anti-microbial, and neuroprotective activities. In this study, we examined the antiproliferative and cytotoxicity properties of resveratrol in Rat...
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The Influence of Antioxidant Resveratrol on Paraquat-induced Oxidative Stress in Cultured Lung Cells

Baek KM, Lee SW, Park JS, Min JH, Hwang G, Do H, Kim H

  • KMID: 2333153
  • J Korean Soc Emerg Med.
  • 2012 Aug;23(4):543-550.
PURPOSE: Paraquat (1,1'-dimethy-4,4'-bipyridinium dichloride, PQ) is an effective and widely used herbicide, which was introduced commercially in 1962. It is reduced by an electron donor, such as NADPH, and then...
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Effect of resveratrol on the metastasis of 4T1 mouse breast cancer cells in vitro and in vivo

Lee HS, Ha AW, Kim WK

  • KMID: 2313607
  • Nutr Res Pract.
  • 2012 Aug;6(4):294-300.
We investigated the effects of resveratrol on metastasis in in vitro and in vivo systems. 4T1 cells were cultured in the presence of various concentrations (0-30 micromol/L) of resveratrol. For...
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Anti-obesity effect of resveratrol-amplified grape skin extracts on 3T3-L1 adipocytes differentiation

Zhang XH, Huang B, Choi SK, Seo JS

  • KMID: 2313606
  • Nutr Res Pract.
  • 2012 Aug;6(4):286-293.
Resveratrol (3,4,5-trihydroxy-trans-stilbene), a phytoalexin found in grape skin, grape products, and peanuts as well as red wine, has been reported to have various biological and pharmacological properties. The purpose of...
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AMP-activated protein kinase Activating Agent and Its Implication

Choi HC

AMP-activated protein kinase (AMPK) is an important cellular fuel sensor. Activation of AMPK requires phosphorylation at threonine (Thr)-172, which resides in the activation loop of the alpha1 and alpha2 subunits....
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