Nat Prod Sci.  2019 Sep;25(3):244-247. 10.20307/nps.2019.25.3.244.

Flavestin K, An Isoprenylated Stilbene from the Leaves of Macaranga recurvata Gage

Affiliations
  • 1Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia. tjitjiktjahjandarie@fst.unair.ac.id
  • 2Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Mulawarman, Samarinda, Indonesia.
  • 3Department of Management, Sekolah Tinggi Ilmu Ekonomi Muara Teweh, North Barito, Muara Teweh, Indonesia.

Abstract

A new isoprenylated stilbene, flavestinK (1) together with two known isoprenylated stilbenes, flavestin B (2), flavestin G (3), and two isoprenilated flavanones, 4-O-methyl-8-isoprenylnaringenin (4) and 8-isoprenyl-5,7-dihydroxyflavanone (5) were isolated from the leaves of Macaranga recurvata Gage. All of the structures have been determined based on HRESIMS, 1D and 2D NMR spectral data. All of the isolated compounds were evaluated for their cytotoxicity against three human cancer cells (HeLa, T47D and WiDr). Compound 1 showed higher activity than doxorubicin against HeLa cells with ICâ‚…â‚€ value of 13.1 µg/mL.

Keyword

Flavestin K; Stilbene; Macaranga recurvata; Cytotoxicity

MeSH Terms

Doxorubicin
Euphorbiaceae*
Flavanones
HeLa Cells
Humans
Stilbenes
Doxorubicin
Flavanones
Stilbenes

Figure

  • Fig. 1 Stilbenes and flavonoids 1 – 5 isolated from the leaves of M. recurvata.

  • Fig. 2 Selected HMBC correlations for flavestin K (1).


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