Chonnam Med J.  2010 Aug;46(2):67-73. 10.4068/cmj.2010.46.2.67.

Sirt1 as a New Therapeutic Target in Metabolic and Age-Related Diseases

• Lee DH

• KMID: 1730001
• DOI: http://doi.org/10.4068/cmj.2010.46.2.67

Abstract

Sirt1 among the mammalian sirtuins has generated intense scientific interest in recent years, mainly because of its effects on longevity, metabolism, and other aging-related processes. Via nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylation, Sirt1 can regulate important metabolic regulators. Sirt1 is involved in insulin secretion in the pancreas, fatty acid oxidation in liver and skeletal muscle, hepatic gluconeogenesis during fasting, the suppression of fat storage in white adipose tissue, and the enhancement of insulin sensitivity in skeletal muscle. It also communicates with AMP-activated protein kinase (AMPK). Resveratrol, a prototype of Sirt1 activator, can induce similar changes reminiscent of caloric restriction in insulin-resistant obese rodent models, although clinical studies are still limited. Intensive research efforts are now targeting Sirt1 for pharmacologic interventions in aging and age-related metabolic and degenerative disorders.

Keyword

Sirt1; AMP-activated protein kinases; Caloric restriction; Longevity

MeSH Terms

Adipose Tissue, White
Aging
AMP-Activated Protein Kinases
Caloric Restriction
Fasting
Gluconeogenesis
Insulin
Insulin Resistance
Liver
Longevity
Muscle, Skeletal
NAD
Pancreas
Rodentia
Sirtuins
Stilbenes
AMP-Activated Protein Kinases
Insulin
NAD
Sirtuins
Stilbenes