J Breast Cancer.  2019 Jun;22(2):210-218. 10.4048/jbc.2019.22.e27.

The Correlation between IL-1β-C31T Gene Polymorphism and Susceptibility to Breast Cancer

• Eras N
• Daloglu FT
• Çolak T
• Guler M
• Akbas E

• KMID: 2450116
• DOI: http://doi.org/10.4048/jbc.2019.22.e27

Abstract

PURPOSE
Interleukin-1 beta (IL-1β), a pro-inflammatory cytokine, has been shown to influence breast cancer susceptibility. The relationship between its risk of breast cancer and IL-1β-C31T polymorphism has been demonstrated, but the results remain controversial. Therefore, our study aimed to investigate the correlation between the IL-1β-C31T gene polymorphism and susceptibility to breast cancer.
METHODS
The genotype frequencies of IL-1β-C31T polymorphism were compared between 204 breast cancer cases and 210 controls using polymerase chain reaction and restriction fragment length polymorphism techinques. Further multivariate binary logistic regression analyses were used to assess the association between IL-1β-C31T polymorphism and breast cancer risk.
RESULTS
The frequency of the T allele of IL-1β-C31T polymorphism in breast cancer cases was significantly higher than that in the controls (56.1% vs. 47.9%). The frequencies of genotypes CC, CT, and TT in the cases were 22.1%, 43.6%, and 34.3%, respectively, while in the control group they were 24.3%, 55.7%, and 20.0%, respectively. There was a significant difference between the prevalence of TT genotype in the 2 groups (adjusted odds ratio [OR], 2.06; 95% confidence interval [CI], 1.16-3.66; p"‰ ="‰ 0.014). Breast cancer risk increased in women with TT genotype, body mass index (BMI) ≥ 25 kg/m2 (OR, 2.19; 95% CI, 1.09-4.36), late age at first birth (OR, 2.43; 95% CI, 1.29-4.56), postmenopausal status (OR, 3.15; 95% CI, 1.39-7.16), and negative smoking history (OR, 2.52; 95% CI, 1.32-4.82). Furthermore, increase in breast cancer risk among women diagnosed with invasive ductal carcinoma was associated with CT/TT genotypes (OR, 2.82; 95% CI, 1.38-5.76).
CONCLUSION
The IL-1β-C31T polymorphism affects breast cancer susceptibility, especially in women with late age at first birth, high BMI, postmenopausal status, negative smoking history, and invasive ductal carcinoma. Our study adds to the evidence about the importance of IL-1β-C31T polymorphism in breast cancer susceptibility.

Keyword

Breast neoplasms; Genetic susceptibility; Interleukin-1beta; Polymorphism, genetic

MeSH Terms

Alleles
Birth Order
Body Mass Index
Breast Neoplasms*
Breast*
Carcinoma, Ductal
Female
Genetic Predisposition to Disease
Genotype
Humans
Interleukin-1beta
Logistic Models
Odds Ratio
Polymerase Chain Reaction
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Prevalence
Smoke
Smoking
Interleukin-1beta
Smoke