Ann Dermatol.  1995 Oct;7(4):299-302. 10.5021/ad.1995.7.4.299.

Polymorphism in the IL-1 Receptor Antagonist Gene in Vitiligo

Abstract

BACKGROUND
The severity of several chronic inflammatory diseases was reported to be associated with polymorphism of the IL-1 receptor antagonist gene(IL-lrn).
OBJECTIVE
This study was performed to study the polymorphism of the IL-1rn in vitiligo and in the normal Korean population.
METHODS
Thirty one cases of vitiligo and seventy nine normal Koreans as control were studied for the polymorphism of IL-1 rn.
RESULTS
The frequency of allele 2 of the IL- I rn in 31 patients with vitiligo was compared with that of the 79 healthy controls. The frequency of allele 2 was 1.6% in vitiligo patients and 3.8% in the normal controls.
CONCLUSION
There was no significant difference in the frequency of allele 2 between the vitiligo patients and normal controls.

Keyword

IL-1 receptor antagonist; IL-1 receptor antagonist gene; Polymorphism; Vitiligo
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