Korean J Physiol Pharmacol.  2002 Oct;6(5):235-240.

The Preventive Effects of Bcl-2 and Bcl-xL on Lovastatin-induced Apoptosis of C6 Glial Cells

Affiliations
  • 1Department of Pharmacology, Yonsei University Wonju College of Medicine, Gangwon-do, Korea. jwchoiphar@wonju.yonsei.ac.kr
  • 2Institute of Basic Medical Science, Yonsei University Wonju College of Medicine, Gangwon-do, Korea.
  • 3The Institute of Functional Biomaterials and Biotechnology, Yonsei University, Gangwon-do, Korea.
  • 4Department of Biology, Yonsei University College of Science, Seoul, Korea.

Abstract

It has been reported that lovastatin induced cell death and suppressed proliferation in various cell lines. In this study, we examined whether the cytotoxic effects of lovastatin could be prevented by Bcl-2 or Bcl-xL in C6 glial cells. Overexpression of human Bcl-2 or Bcl-xL prevented lovastatin (25microM)- induced changes such as DNA fragmentation, chromatin condensation, disruption of cell membrane, and cleavage of poly (ADP-ribose) polymerase. Lovastatin-induced inhibition of cell proliferation was unaffected by Bcl-2 or Bcl-xL overexpression. These results suggest that Bcl-2 and Bcl-xL can prevent lovastatin-induced apoptosis in C6 glial cells, though the inhibition of proliferation remains unaffected by these proteins.

Keyword

Lovastatin; Apoptosis; C6; Bcl-2; Bcl-xL

MeSH Terms

Apoptosis*
Cell Death
Cell Line
Cell Membrane
Cell Proliferation
Chromatin
DNA Fragmentation
Humans
Lovastatin
Neuroglia*
Chromatin
Lovastatin
Full Text Links
  • KJPP
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr