- Evaluation of normal morphology, DNA fragmentation, and hyaluronic acid binding ability of human spermatozoa after using four different commercial media for density gradient centrifugation
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Lee D, Jee BC
- KMID: 2469601
- Clin Exp Reprod Med.
- 2019 Mar;46(1):8-13.
- doi: 10.5653/cerm.2019.46.1.8
OBJECTIVE: Density gradient centrifugation (DGC) is frequently used to isolate high-motility fractions of spermatozoa. We compared the efficacy of four DGC media in terms of the percentage of morphologically normal... -
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- Specific tail swelling pattern in hypo-osmotic solution as a predictor of DNA fragmentation status in human spermatozoa
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Kim SW, Nho EJ, Lee JY, Jee BC
- KMID: 2469590
- Clin Exp Reprod Med.
- 2019 Dec;46(4):147-151.
- doi: 10.5653/cerm.2019.00458
OBJECTIVE: The aim of this study was to investigate DNA fragmentation status in human spermatozoa according to specific tail swelling patterns determined via hypo-osmotic swelling test (HOST). METHODS: Frozen semen samples... -
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- Effects of Trifluoperazine on the PC12 Cell Injury
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Kim W, Choi Y, Lee HY, Kim Y, Lee KY
- KMID: 2275050
- Chonnam Med J.
- 1997 Jun;33(1):89-104.
Trifluoperazine(TFP) is a well known antipsycotic phenothiazine derivative. TFP is also known as a calmodulin antagonist in molecular level. Although there have been many reports on the role of TFP... -
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- What should be done for men with sperm DNA fragmentation?
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Kim GY
- KMID: 2419525
- Clin Exp Reprod Med.
- 2018 Sep;45(3):101-109.
- doi: 10.5653/cerm.2018.45.3.101
In an age when a small quantity of sperm can lead to pregnancy through in vitro fertilization or intracytoplasmic sperm injection, selecting healthy sperm is important. Sperm DNA fragmentation (SDF)... -
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- Sperm DNA Fragmentation and Standard Semen Parameters in Algerian Infertile Male Partners
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Boushaba S, Belaaloui
- KMID: 2320733
- World J Mens Health.
- 2015 Apr;33(1):1-7.
- doi: 10.5534/wjmh.2015.33.1.1
PURPOSE: To date, standard semen parameters have been the only parameters investigated in sperm samples of infertile men in Algeria. We investigated, for the first time, semen parameters according to... -
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- Seminal Tumor Necrosis Factor-alpha Level and Sperm Nuclear DNA Integrity in Healthy Donors
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Kim HJ, Jee BC, Moon JH, Lee JR, Suh CS, Kim SH
- KMID: 1986912
- Korean J Reprod Med.
- 2009 Mar;36(1):35-43.
OBJECTIVES: Seminal concentration of tumor necrosis factor-alpha (TNF-alpha) relevant to sperm nuclear DNA integrity has not been studied. The present study aimed to evaluate seminal concentration of TNF-alpha in correlation... -
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- Current status and perspectives of researches on programmed cell death in immune system
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Chung YH
- KMID: 2365358
- Allergy.
- 1995 Dec;15(4):569-595.
Programmed cell death(PCD), or apoptosis, is a distinct process of cell death in response to specific physiological or toxic signal. This genetically programmed form of cellular suicide is intimately involved... -
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- Sperm nuclear DNA fragmentation and chromatin structure in one-day-old ejaculated sperm
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Jee BC, Suh CS, Shin MS, Lee HJ, Lee JH, Kim SH
- KMID: 2045699
- Clin Exp Reprod Med.
- 2011 Jun;38(2):82-86.
- doi: 10.5653/cerm.2011.38.2.82
OBJECTIVE: To evaluate sperm nuclear DNA fragmentation and chromatin structure after 18 hours'incubation at room temperature. METHODS: Twenty-eight male partners who participating IVF treatment were prospectively included in this study. Ejaculated... -
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- Efficient isolation of sperm with high DNA integrity and stable chromatin packaging by a combination of density-gradient centrifugation and magnetic-activated cell sorting
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Chi HJ, Kwak SJ, Kim SG, Kim YY, Park JY, Yoo CS, Park IH, Sun HG, Kim JW, Lee KH
- KMID: 2364656
- Clin Exp Reprod Med.
- 2016 Dec;43(4):199-206.
- doi: 10.5653/cerm.2016.43.4.199
OBJECTIVE: This study was carried out to investigate the correlations of the sperm DNA fragmentation index (DFI) with semen parameters and apoptosis, and to investigate the effects of density-gradient centrifugation... -
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- Relationship between phospholipase C zeta immunoreactivity and DNA fragmentation and oxidation in human sperm
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Park JH, Kim SK, Kim J, Kim JH, Chang JH, Jee BC, Kim SH
- KMID: 2148936
- Obstet Gynecol Sci.
- 2015 May;58(3):232-238.
- doi: 10.5468/ogs.2015.58.3.232
OBJECTIVE: The study aimed to evaluate the feasibility and reproducibility of measuring phospholipase C zeta (PLCzeta) using immunostaining in human sperm and to investigate the relationship between PLCzeta immunoreactivity and... -
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- Protective mechanism of glucose against alloxan-induced beta-cell damage: pivotal role of ATP
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Rho HW, Lee JN, Kim HR, Park BH, Park JW
- KMID: 927128
- Exp Mol Med.
- 2000 Mar;32(1):12-17.
Glucose prevents the development of diabetes induced by alloxan. In the present study, the protective mechanism of glucose against alloxan-induced beta-cell damage was investigated using HIT-T 15 cell, a Syrian... -
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- Apoptosis induced by changes in the temperature during whole embryo culture of postimplantation rat embryos
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Lee HJ, Seol EY, Kim MH, Park YM, Park HW
- KMID: 1937886
- Korean J Anat.
- 1998 Oct;31(5):761-770.
It has been reported that heat shock (43degrees C) induces an episode of cell death in developing central nervous system as part of pathogenesis leading to abnormal growth and development.... -
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- Does conventional freezing affect sperm DNA fragmentation?
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Le MT, Nguyen TT, Nguyen TT, Nguyen TV, Nguyen TA, Nguyen QH, Cao TN
- KMID: 2452645
- Clin Exp Reprod Med.
- 2019 Jun;46(2):67-75.
- doi: 10.5653/cerm.2019.46.2.67
OBJECTIVE: Sperm cryopreservation has been widely used in assisted reproductive technology, as it offers great potential for the treatment of some types of male infertility. However, cryopreservation may result in... -
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- Evaluation of sperm DNA fragmentation using multiple methods: a comparison of their predictive power for male infertility
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Javed A, Talkad MS, Ramaiah MK
- KMID: 2469602
- Clin Exp Reprod Med.
- 2019 Mar;46(1):14-21.
- doi: 10.5653/cerm.2019.46.1.14
OBJECTIVE: The usual seminal profile has been customarily used for diagnosing male infertility based on an examination of semen samples. However, sperm DNA fragmentation has also been causally linked to... -
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- The Development of Apoptosis and DNA Fragmentation in Transient Ischemic Model in Rats, and Roles of Dexamethasoneand Hypothermia
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Kim DS, Woo TJ, Baik SW
- KMID: 2091644
- Korean J Anesthesiol.
- 2001 Dec;41(6):758-766.
- doi: 10.4097/kjae.2001.41.6.758
BACKGROUND: Neuronal cell death after brain ischemia occurs predominately by necrosis, whereas only a minor fraction of cell death may occur through apoptosis. Authors investigated DNA fragmentation and apoptotic... -
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- Effects of Sevoflurane and Ischemic Preconditioning on Neurologic Injury and Bcl-2 Family Protein mRNA Expression after Transient Spinal Ischemia in the Rats
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Kang SH, Kim ES, Baek SH, Kwon JY
- KMID: 2228546
- Korean J Crit Care Med.
- 2004 Jun;19(1):20-31.
BACKGROUND: Spinal cord injury occurring as the result of surgical repair of thoracic and thoracoabdominal aortic disease remains a devastating complication. Anesthetic and ischemic preconditioning have been known to prevent... -
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- Effect of Microsurgical Varicocelectomy on Human Sperm Nucleus DNA Integrity
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Kim GY, Lee JS, Chi HJ, Kim JH
- KMID: 2071002
- Korean J Reprod Med.
- 2010 Sep;37(3):245-251.
OBJECTIVE: Human sperm nucleus DNA damage may negatively affect pregnancy outcome, and the spermatozoa of infertile men have more DNA damage than that of fertile men. The aim of this... -
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- Sulindac-induced Apoptosis without Oligonucleosomal DNA Fragmentation in HT-29 Cells: Its Special References to Mitochondrial Pathway
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Park KJ, Kwon Y, Kim SH, Kim MC, Choi HJ, Kim YH, Cho SH, Jung GJ, Kim SH, Kwon HC
- KMID: 1566533
- J Korean Soc Coloproctol.
- 2004 Aug;20(4):191-198.
PURPOSE: This study was undertaken to reveal the molecular mechanism underlying sulindac-induced apoptosis in the human colon cancer cell line HT-29 (mutant p53). METHODS: Apoptosis was determined by using Hoechst... -
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- NELL2 gene as regulator of cell cycle in neuron differentiation
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Joung MR, Oh YM, Park WS, Park SK
- KMID: 2279788
- Korean J Pediatr.
- 2006 Oct;49(10):1100-1105.
- doi: 10.3345/kjp.2006.49.10.1100
PURPOSE: Because NELL2 expression is strictly restricted only in neurons in developing and post- differentiated neural tissues, it is thought to be involved in the neuronal differentiation during development and... -
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- The Change of Molecular Event of p53 by Cisplatin and 5-Fluorouracil in Hypopharyngeal Cell Line(PNUH-12)
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Chon KM, Lee BJ, Lee IW, Moon YI, Roh HJ, Wang SG, Goh EK, Kim SR, Lee EY
- KMID: 2074461
- Korean J Otolaryngol-Head Neck Surg.
- 2002 Oct;45(10):984-989.
OBJECTIVES AND BACKGROUND: In head and neck cancer including hypopharyngeal carcinoma, cisplatin and 5-fluorouracil usually have been used as neoadjuvant chemotherapeutic agents. We investigated the difference in the influences of... -
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