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Sepsis induces variation of intestinal barrier function in different phase through nuclear factor kappa B signaling

Cao YY, Wang ZH, Xu QC, Chen Q, Wang Z, Lu WH

The intestinal barrier function disrupted in sepsis, while little is known about the variation in different phases of sepsis. In this study, mouse models of sepsis were established by caecal...
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Cardamonin exerts a protective effect against autophagy and apoptosis in the testicles of diabetic male rats through the expression of Nrf2 via p62-mediated Keap-1 degradation

Samir SM, Elalfy M, Nashar EME, Alghamdi MA, Hamza E, Serria MS, Elhadidy MG

Cardamonin (CARD) is a chalconoid with anti-inflammatory and antioxidant properties, and it is present in several plants. We sought to explore whether CARD exerts any positive effects against hyperglycemia-induced testicular...
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Vanillin oxime inhibits lung cancer cell proliferation and activates apoptosis through JNK/ERK-CHOP pathway

Shen J, Su Z

Lung cancer despite advancement in the medical field continues to be a major threat to human lives and accounts for a high proportion of fatalities caused by cancers globally. The...
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Melatonin mitigates the adverse effect of hypoxia during myocardial differentiation in mouse embryonic stem cells

Lee JH, Yoo YM, Lee B, Jeong S, Tran DN, Jeung EB

Background: Hypoxia causes oxidative stress and affects cardiovascular function and the programming of cardiovascular disease. Melatonin promotes antioxidant enzymes such as superoxide dismutase, glutathione reductase, glutathione peroxidase, and catalase. Objectives: This...
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Developmentally regulated GTP-binding protein 2 levels in prostate cancer cell lines impact docetaxel-induced apoptosis

Kim SC, Lee WH, Kim SH, Abdulkhayevich AA, Park JW, Kim YM, Moon KH, Lee SH, Park S

Purpose: This study aimed to confirm the association between developmentally regulated GTP-binding protein 2 (DRG2) expression and docetaxel-induced apoptosis and to determine whether prostate cancer responses to docetaxel treatment differ...
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Restoration of Cavernous Veno-Occlusive Function through Chronic Administration of a Jun-Amino Terminal Kinase Inhibitor and a LIM-Kinase 2 Inhibitor by Suppressing Cavernous Apoptosis and Fibrosis in a Rat Model of Cavernous Nerve Injury: A Comparison with a Phosphodiesterase Type 5 Inhibitor

Cho MC, Lee J, Park J, Kim SW

Purpose: To determine if chronic administration of Jun-amino terminal kinase (JNK)-inhibitors and LIM-kinase 2 (LIMK2)-inhibitors from the immediate post-injury period in a rat model of cavernous-nerve-crush-injury could normalize cavernousveno-occlusive-function, and...
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Methanol extracts of Asarum sieboldii Miq. induces apoptosis via the caspase pathway in human FaDu hypopharynx squamous carcinoma cells

Lee SA, Park BR, Kim CS

Asarum sieboldii Miq. (Aristolochiaceae) is a perennial herbaceous plant and has been used as traditional medicine for treating diseases, cold, fever, phlegm, allergies, chronic gastritis, and acute toothaches. Also, it...
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Experimental Tracheal Replacement: Angiogenesis and Null Apoptosis Promote Stenosis

Santibáñez-Salgado JA, Sotres-Vega A, Gaxiola-Gaxiola MO, Villalba-Caloca J, Lozoya KB, Zúñiga-Ramos JA

Background: Tracheal replacement is a challenge for thoracic surgeons due to stenosis in the trachea-prosthesis anastomosis. We propose that stenosis occurs due to fibrosis as a result of an abnormal...
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Effect of TNF-α and IL-6 on Compact Bone-Derived Cells

Zhang Y, Li X, Chihara T, Dong H, Kagami H

Background: Although bone tissue engineering has already been applied clinically, its regeneration efficacy is not always sufficient. Local inflammatory cytokines are considered as the major factors that induce apoptosis of transplanted...
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Allomyrina dichotoma larva extract attenuates free fatty acid-induced lipotoxicity in pancreatic beta cells

Kim K, Kwak MK, Bae GD, Park EY, Baek DJ, Kim CY, Jang SE, Jun HS, Oh YS

BACKGROUD/OBJECTIVES: Allomyrina dichotoma larva (ADL), one of the many edible insects recognized as future food resources, has a range of pharmacological activities. In a previous study, an ADL extract (ADLE)...
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Treadmill Running Improves Spatial Learning Memory Through Inactivation of Nuclear Factor Kappa B/Mitogen-Activated Protein Kinase Signaling Pathway in Amyloid-β-Induced Alzheimer Disease Rats

Kim SH, Ko YJ, Kim JY, Sim YJ

Purpose: Exercise is known to reduce proinflammatory cytokines production and apoptosis. We investigated the effect of treadmill running on spatial learning memory in terms of activation of nuclear factor kappa...
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Differential Signaling and Virus Production in Calu-3 Cells and Vero Cells upon SARS-CoV-2 Infection

Park BK, Kim D, Park S, Maharjan S, Kim J, Choi JK, Akauliya M, Lee Y, Kwon HJ

Severe acute respiratory syndrome CoV-2 (SARS-CoV-2) is responsible for the current coronavirus disease 2019 (COVID-19) pandemic. Signaling pathways that are essential for virus production have potential as therapeutic targets against...
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Protective Role of Transduced Tat-Thioredoxin1 (Trx1) against Oxidative Stress-Induced Neuronal Cell Death via ASK1-MAPK Signal Pathway

Yeo EJ, Eum WS, Yeo HJ, Choi YJ, Sohn EJ, Kwon HJ, Kim DW, Kim DS, Cho SW, Park J, Han KH, Lee KW, Park JK, Shin MJ, Choi SY

Oxidative stress plays a crucial role in the development of neuronal disorders including brain ischemic injury. Thioredoxin 1 (Trx1), a 12 kDa oxidoreductase, has anti-oxidant and anti-apoptotic functions in various...
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Upregulation of miR-20b Protects Against Cerebral Ischemic Stroke by Targeting Thioredoxin Interacting Protein (TXNIP)

Yang D, Tan Y, Li H, Zhang X, Li X, Zhou F

  • KMID: 2515815
  • Exp Neurobiol.
  • 2021 Apr;30(2):170-182.
  • doi: 10.5607/en20046
Dysregulation of microRNAs (miRNAs) is involved in abnormal development and pathophysiology in the brain. Although miR-20b plays essential roles in various human diseases, its function in cerebral ischemic stroke remains...
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The role of microRNAs in cell death pathways

Jang JH, Lee TJ

MicroRNAs (miRNAs) are a class of noncoding RNAs that negatively regulate target messenger RNAs. In multicellular eukaryotes, numerous miRNAs perform basic cellular functions, including cell proliferation, differentiation, and death. Abnormal...
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Apoptotic activity of demethoxycurcumin in MG-63 human osteosarcoma cells

Kang KR, Kim JS, Kim TH, Seo JY, Park JH, Chun HS, Yu SK, Kim HJ, Kim CS, Kim DK

Demethoxycurcumin (DMC), which is a curcuminoid found in turmeric, has anti-proliferative effects on cancer cells. However, the effect of DMC on osteosarcoma has not been established. The aim of this...
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Vinpocetine inhibits the proliferation and induces apoptosis in human colon cancer cells

Kim MK, Park HJ, Kim Y, Kim YI, Bae SK, Kim HJ, Bae MK

Vinpocetine induces anti-inflammatory effects in various inflammatory diseases via the inhibition of phosphodiesterase type-1-independent nuclear factor-κB signaling pathway and the release of inflammatory cytokines. In this study, we investigated the...
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JEG-3 placental cells in toxicology studies: a promising tool to reveal pregnancy disorders

Olivier E, Wakx A, Fouyet S, Dutot M, Rat P

Placental alterations are responsible for adverse pregnancy outcomes like preeclampsia and intrauterine growth restriction. And yet, placenta toxicology has not become a fully-f ledged toxicology field. Because placenta is very...
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Puerarin pretreatment attenuates cardiomyocyte apoptosis induced by coronary microembolization in rats by activating the PI3K/Akt/GSK-3β signaling pathway

Chen ZQ, Zhou Y, Huang JW, Chen F, Zheng J, Li HL, Li T, Li L

Coronary microembolization (CME) is associated with cardiomyocyte apoptosis and cardiac dysfunction. Puerarin confers protection against multiple cardiovascular diseases, but its effects and specific mechanisms on CME are not fully known....
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Modulatory Potential of LncRNA Zfas1 for Inflammation and Neuronal Apoptosis in Temporal Lobe Epilepsy

He C, Su C, Zhang W, Zhou Q, Shen X, Yang J, Shi N

Purpose: This study aimed to elucidate whether lncRNA ZFAS1 is involved in neuronal apoptosis and inflammation in temporal lobe epilepsy (TLE). Materials and Methods: Ninety-six TLE patients were recruited, and their...
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