- Domperidone Exerts Antitumor Activity in Triple-Negative Breast Cancer Cells by Modulating Reactive Oxygen Species and JAK/STAT3 Signaling
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Shakya R, Byun MR, Joo SH, Chun KS, Choi JS
- KMID: 2547502
- Biomol Ther.
- 2023 Nov;31(6):692-699.
- doi: 10.4062/biomolther.2023.173
The lack of molecular targets hampers the treatment of triple-negative breast cancer (TNBC). In this study, we determined the cytotoxicity of domperidone, a dopamine D2 receptor (DRD2) antagonist in human... -
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- Licochalcone H Targets EGFR and AKT to Suppress the Growth of Oxaliplatin -Sensitive and -Resistant Colorectal Cancer Cells
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Lee SO, Lee MH, Kwak AW, Lee JY, Yoon G, Joo SH, Choi YH, Park JW, Shim JH
- KMID: 2547499
- Biomol Ther.
- 2023 Nov;31(6):661-673.
- doi: 10.4062/biomolther.2023.155
Treatment of colorectal cancer (CRC) has always been challenged by the development of resistance. We investigated the antiproliferative activity of licochalcone H (LCH), a regioisomer of licochalcone C derived from... -
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- Aquaporin-3 Downregulation in Vitiligo Keratinocytes Increases Oxidative Stress of Melanocytes
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Kim NH, Kim HJ, Lee AY
- KMID: 2547497
- Biomol Ther.
- 2023 Nov;31(6):648-654.
- doi: 10.4062/biomolther.2023.112
Oxidative stress-induced melanocyte apoptosis is linked to the immune system and plays a critical role in the pathogenesis of vitiligo. Aquaporin-3 (AQP3), which is downregulated in vitiligo keratinocytes, regulates intracellular... -
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- Neuroprotective effects of hesperetin on H 2 O 2 -induced damage in neuroblastoma SH-SY5Y cells
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Moon HR, Yun JM
- KMID: 2546947
- Nutr Res Pract.
- 2023 Oct;17(5):899-916.
- doi: 10.4162/nrp.2023.17.5.899
BACKGROUND/OBJECTIVES: Oxidative stress is a fundamental neurodegenerative disease trigger that damages and decimates nerve cells. Neurodegenerative diseases are chronic central nervous system disorders that progress and result from neuronal degradation... -
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- Novel Insight into the Cellular and Molecular Signalling Pathways on Cancer Preventing Effects of Hibiscus sabdariffa: A Review
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Yasmin R, Gogoi S, Bora J, Chakraborty A, Dey S, Ghaziri G, Bhattacharjee S, Singh LH
- KMID: 2546894
- J Cancer Prev.
- 2023 Sep;28(3):77-92.
- doi: 10.15430/JCP.2023.28.3.77
A category of diseases known as cancer includes abnormal cell development and the ability to infiltrate or spread to other regions of the body, making them a major cause of... -
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- Ethanol Extract of Smilax glabra Induces Apoptotic Cell Death in Human YD10B Oral Squamous Cell Carcinoma Cells
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Hwang YS
- KMID: 2546581
- J Dent Hyg Sci.
- 2023 Sep;23(3):216-224.
- doi: 10.17135/jdhs.2023.23.3.216
Background: Smilax glabra has various pharmacological activities and is widely used as a herbal medicine. Although the incidence of oral cancer is low, the recurrence rate is high, and the... -
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- Cell clusters in intervertebral disc degeneration: an attempted repair mechanism aborted via apoptosis
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Lama P, Tiwari J, Mutreja P, Chauhan S, Harding IJ, Dolan T, Adams MA, Maitre CL
- KMID: 2546467
- Anat Cell Biol.
- 2023 Sep;56(3):382-393.
- doi: 10.5115/acb.23.067
Cell clusters are a histological hallmark feature of intervertebral disc degeneration. Clusters arise from cell proliferation, are associated with replicative senescence, and remain metabolically, but their precise role in various... -
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- MicroRNA-765 is upregulated in myelodysplastic syndromes and induces apoptosis via PLP2 inhibition in leukemia cells
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Kang SH, Choi JS
- KMID: 2546314
- Blood Res.
- 2023 Sep;58(3):133-137.
- doi: 10.5045/br.2023.2023097
Background Epigenetic studies, particularly research on microRNA (miRNA), have flourished. The abnormal expression of miRNA contributes to the development of hematologic malignancies. miR-765 has been reported to inhibit cell proliferation by downregulating... -
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- Losartan Reduces Remodeling and Apoptosis in an Adriamycin-Induced Cardiomyopathy Rat Model
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Kim HA, Kim KC, Lee H, Hong YM
- KMID: 2545973
- J Chest Surg.
- 2023 Sep;56(5):295-303.
- doi: 10.5090/jcs.23.044
Background: The use of Adriamycin (ADR), also known as doxorubicin, as a chemotherapy agent is limited by its detrimental adverse effects, especially cardiotoxicity. Recent studies have emphasized the crucial role... -
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- Electroacupuncture-Modulated MiR-106b-5p Expression Enhances Autophagy by Targeting Beclin-1 to Promote Motor Function Recovery After Spinal Cord Injury in Rats
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Guo S, Chen J, Yang Y, Li X, Tang Y, Gui Y, Chen J, Xu j
- KMID: 2546050
- Neurospine.
- 2023 Sep;20(3):1011-1027.
- doi: 10.14245/ns.2346446.223
Objective: Electroacupuncture (EA) has a definite effect on the treatment of spinal cord injuries (SCIs), but its underlying molecular mechanism remains unclear. Meanwhile, MiR106b-5p is an autophagy- and apoptosis-related microribonucleic... -
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- Omega-3 fatty acids upregulate Nrf2 expression and attenuate apoptosis, inflammation, and fibrosis in a rat model of cyclosporine-induced nephropathy
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Lee JY, Son YK, Lee MH, Lee SM, Kim SE, An WS
- KMID: 2546153
- Kosin Med J.
- 2023 Sep;38(3):184-192.
- doi: 10.7180/kmj.23.112
Background: Cyclosporine A (CsA)-induced kidney injury is characterized by renal impairment with inflammatory cell infiltrations, apoptosis, fibrosis, and hypoxic injury. It is not clear whether omega-3 fatty acids (O-3 FAs),... -
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- Lipid emulsion inhibits the cardiac toxicity caused by chloroquine via inhibition of reactive oxygen species production
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Lee SH, Ok SH, Ahn SH, Sim G, Kim HJ, Kim M, Yoon S, Sohn JT
- KMID: 2544556
- Korean J Anesthesiol.
- 2023 Aug;76(4):368-382.
- doi: 10.4097/kja.22572
Background: Lipid emulsion (LE) is effective in treating intractable cardiac depression induced by the toxicity of highly lipid-soluble drugs including local anesthetics. However, the effect of LE on chloroquine (CQ)-evoked... -
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- Dihydroaustrasulfone alcohol induces apoptosis in nasopharyngeal cancer cells by inducing reactive oxygen speciesdependent inactivation of the PI3K/AKT pathway
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Tan KT, Shih YH, Gong JY, Zhang X, Huang CY, Su JH, Sheu JH, Lin CC
- KMID: 2544140
- Korean J Physiol Pharmacol.
- 2023 Jul;27(4):383-398.
- doi: 10.4196/kjpp.2023.27.4.383
Dihydroaustrasulfone alcohol (DA), the synthetic precursor of a natural compound (austrasulfone) isolated from the coral species Cladiella australis, has shown cytotoxic effects against cancer cells. However, it is unknown whether... -
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- Melatonin acts synergistically with pazopanib against renal cell carcinoma cells through p38 mitogen-activated protein kinase-mediated mitochondrial and autophagic apoptosis
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Lai CP, Chen YS, Ying TH, Kao CY, Chiou HL, Kao SH, Hsieh YH
- KMID: 2547119
- Kidney Res Clin Pract.
- 2023 Jul;42(4):487-500.
- doi: 10.23876/j.krcp.22.114
Background: Mounting evidence indicates that melatonin has possible activity against different tumors. Pazopanib is an anticancer drug used to treat renal cell carcinoma (RCC). This study tested the anticancer activity... -
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- Anti-Fibrotic Effects of DL-Glyceraldehyde in Hepatic Stellate Cells via Activation of ERK-JNK-Caspase-3 Signaling Axis
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Samsuzzaman M, Kim SY
- KMID: 2544065
- Biomol Ther.
- 2023 Jul;31(4):425-433.
- doi: 10.4062/biomolther.2022.131
During liver injury, hepatic stellate cells can differentiate into myofibroblast-like structures, which are more susceptible to proliferation, migration, and extracellular matrix generation, leading to liver fibrosis. Anaerobic glycolysis is associated... -
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- αα-Pinene Attenuates Methamphetamine-Induced Conditioned Place Preference in C57BL/6 Mice
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Lee C, Jang JH, Park GH
- KMID: 2544063
- Biomol Ther.
- 2023 Jul;31(4):411-416.
- doi: 10.4062/biomolther.2022.132
Methamphetamine (METH) is a powerful neurotoxic psychostimulant affecting dopamine transporter (DAT) activity and leading to continuous excess extracellular dopamine levels. Despite recent advances in the knowledge on neurobiological mechanisms underlying... -
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- Identification of Genes Involved in EGF-induced Apoptosis Using CRISPR/Cas9 Knockout Screening: Implications for Novel Therapeutic Targets in EGFR-Overexpressing Cancers
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Kim JS, Lee JH, Jeon SR, Kim Y, Jeon SH, Wu HG
- KMID: 2544157
- Cancer Res Treat.
- 2023 Jul;55(3):737-745.
- doi: 10.4143/crt.2022.1414
Purpose Exogenous epidermal growth factor (EGF) causes apoptosis in EGF receptor (EGFR)–overexpressing cell lines. The apoptosis-inducing factors could be a therapeutic target. We aimed to determine the mechanism of EGF-induced... -
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- Docetaxel Enhances Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Mediated Apoptosis in Prostate Cancer Cells via Epigenetic Gene Regulation by Enhancer of Zeste Homolog 2
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Lee WH, Kim SC, Kim SH, Yoon JH, Moon KH, Cheon SH, Kwon T, Kim YM, Park JW, Lee SH, Lee JM, Park S, Chung BI
- KMID: 2543311
- World J Mens Health.
- 2023 Jul;41(3):649-658.
- doi: 10.5534/wjmh.220073
Purpose Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising cancer therapeutic agent because of its tumor selectivity and its ability to induce apoptosis in cancer cells while sparing most normal... -
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- Methanol extracts of Undaria pinnatifida induces apoptosis via the death-receptor and Bcl-2 family pathway in human oral cancer cells
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Park BR, Lee SA, Kim CS
- KMID: 2544209
- Oral Biol Res.
- 2023 Jun;47(2):51-58.
- doi: 10.21851/obr.47.02.202306.51
Undaria pinnatifida (UP), commonly known as Wakame, is a brown algae belonging to the seaweed family. It has long been used as traditional medicine to relieve thrombosis and pain in... -
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- Curcumin Enhances the Anticancer Effects of Binimetinib on Melanoma Cells by Inducing Mitochondrial Dysfunction and Cell Apoptosis with Necroptosis
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Lee YJ, Heo JY, Kim DS, Choi YS, Kim S, Nam HS, Lee SH, Cho MK
- KMID: 2542656
- Ann Dermatol.
- 2023 Jun;35(3):217-228.
- doi: 10.5021/ad.22.200
Background: Recent studies suggest that MEK1/2 inhibitors, including binimetinib, significantly improve malignant melanoma (MM) patient survival. Growing evidence suggests that phytochemicals, especially curcumin, can overcome drug resistance in cancer cells... -
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