- Classical Hodgkin lymphoma following follicular lymphoma: a case report
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Kim B
- KMID: 2548352
- J Yeungnam Med Sci.
- 2023 Nov;40(Suppl):S113-S122.
- doi: 10.12701/jyms.2023.00584
The simultaneous, composite, or sequential occurrence of follicular lymphoma (FL) and classical Hodgkin lymphoma (HL), both of which originate from germinal center B-cell, is rare. Questions have been raised with... -
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- METTL3 Affects Spinal Cord Neuronal Apoptosis by Regulating Bcl-2 m6A Modifications After Spinal Cord Injury
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Guo S, Lin T, Chen G, Shangguan Z, Zhou L, Chen Z, Shi T, Chen D, Wang Z, Liu W
- KMID: 2543563
- Neurospine.
- 2023 Jun;20(2):623-636.
- doi: 10.14245/ns.2346170.085
Objective: Spinal cord injury (SCI) is a severe type of neurological trauma. N6-methyladenosine (m6A) modification is one of the most common internal modifications of RNA. The role of METTL3, the... -
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- Upregulation of MicroRNA-34a Sensitizes Ovarian Cancer Cells to Resveratrol by Targeting Bcl-2
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Yao S, Gao M, Wang Z, Wang W, Zhan L, Wei B
- KMID: 2518566
- Yonsei Med J.
- 2021 Aug;62(8):691-701.
- doi: 10.3349/ymj.2021.62.8.691
Purpose: Resveratrol (REV), a natural compound found in red wine, exhibits antitumor activity in various cancers, including ovarian cancer (OC). However, its potential anti-tumor mechanisms in OC are not well... -
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- The Role of miR-34c-5p in Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells
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Liu B, Gan W, Jin Z, Wang M, Cui G, Zhang H, Wang H
- KMID: 2519371
- Int J Stem Cells.
- 2021 Aug;14(3):286-297.
- doi: 10.15283/ijsc20188
Background and Objectives: Osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) plays a critical role in the success of lumbar spinal fusion with autogenous bone graft. This study aims... -
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- Hypoxia-Induced Suppression of Antiapoptotic Bcl-2 Expression in Human Bladder Tumor Cells Is Regulated by Caveolin-1-Dependent Adenosine Monophosphate-Activated Protein Kinase Activity
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Cho TJ, Lee DH, Choi BH, Shinn HK, Park CS
- KMID: 2517666
- Int Neurourol J.
- 2021 Jun;25(2):137-149.
- doi: 10.5213/inj.2040444.222
Purpose: Adenosine monophosphate-activated protein kinase (AMPK) is thought to inhibit cell proliferation or promote cell death, but the details remain unclear. In this study, we propose that AMPK inhibits the... -
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- Effect of L-carnitine on the expression of the apoptotic genes Bcl-2 and Bax
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Vardiyan R, Ezati D, Anvari M, Ghasemi N, Talebi A
- KMID: 2506132
- Clin Exp Reprod Med.
- 2020 Sep;47(3):155-160.
- doi: 10.5653/cerm.2019.03440
Objective The genes Bcl-2 and Bax play important roles in apoptosis. Many studies have shown that formalin has a strong deleterious effect on male fertility and can induce apoptosis. L-carnitine... -
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- The Histone Lysine-specific Demethylase 1 Inhibitor, SP2509 Exerts Cytotoxic Effects against Renal Cancer Cells through Downregulation of Bcl-2 and Mcl-1
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Wu K, Woo SM, Kwon TK
- KMID: 2503564
- J Cancer Prev.
- 2020 Jun;25(2):79-86.
- doi: 10.15430/JCP.2020.25.2.79
Lysine-specific histone demethylase 1 (LSD1), also known as KDM1A, can remove the methyl group from lysine 4 and 9 at histone H3, which regulates transcriptional suppression and activation. Recently, high... -
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- Antitumor effect of TW-37, a BH3 mimetic in human oral cancer
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Ahn CH, Lee WW, Jung YC, Shin JA, Hong KO, Choi S, Swarup N, Kim J, Ahn MH, Jung M, Cho SD, Jin B
- KMID: 2470017
- Lab Anim Res.
- 2019 Dec;35(4):194-201.
- doi: 10.1186/s42826-019-0028-7
TW-37 is a small molecule B cell lymphoma-2 (Bcl-2) homology 3 mimetic with potential anticancer activities. However, the in vivo anti-cancer effect of TW-37 in human oral cancer has not... -
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- Serous Adenocarcinoma of Fallopian Tubes: Histological and Immunohistochemical Aspects
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Hyriavenko N, Lyndin M, Sikora K, Piddubnyi , Karpenko L, Kravtsova , Hyriavenko D, Diachenko , Sikora V, Romaniuk A
- KMID: 2454603
- J Pathol Transl Med.
- 2019 Jul;53(4):236-243.
- doi: 10.4132/jptm.2019.03.21
BACKGROUND: Although primary cancer of the fallopian tubes is a relatively rare type of tumor in female reproductive organs, its mortality is quite high. It is important to identify molecular... -
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- ABT-737 ameliorates docetaxel resistance in triple negative breast cancer cell line
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Hwang E, Hwang SH, Kim J, Park JH, Oh S, Kim YA, Hwang KT
- KMID: 2422933
- Ann Surg Treat Res.
- 2018 Nov;95(5):240-248.
- doi: 10.4174/astr.2018.95.5.240
PURPOSE: This study aimed to validate the synergistic effect of ABT-737 on docetaxel using MDA-MB-231, a triple negative breast cancer (TNBC) cell line overexpressing B-cell lymphoma-2 (Bcl-2). METHODS: Western blot analysis... -
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- ZFP36L1 and AUF1 Induction Contribute to the Suppression of Inflammatory Mediators Expression by Globular Adiponectin via Autophagy Induction in Macrophages
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Shrestha A, Pun NT, Park PH
- KMID: 2421722
- Biomol Ther.
- 2018 Sep;26(5):446-457.
- doi: 10.4062/biomolther.2018.078
Adiponectin, a hormone predominantly originated from adipose tissue, has exhibited potent anti-inflammatory properties. Accumulating evidence suggests that autophagy induction plays a crucial role in anti-inflammatory responses by adiponectin. However, underlying... -
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- Effect of BIS depletion on HSF1-dependent transcriptional activation in A549 non-small cell lung cancer cells
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Yun HH, Baek JY, Seo G, Kim YS, Ko JH, Lee JH
- KMID: 2414270
- Korean J Physiol Pharmacol.
- 2018 Jul;22(4):457-465.
- doi: 10.4196/kjpp.2018.22.4.457
The expression of BCL-2 interacting cell death suppressor (BIS), an anti-stress or anti-apoptotic protein, has been shown to be regulated at the transcriptional level by heat shock factor 1 (HSF1)... -
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- Effects and Mechanisms of Metformin on the Proliferation of Esophageal Cancer Cells In Vitro and In Vivo
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Tang JC, An R, Jiang YQ, Yang J
- KMID: 2388323
- Cancer Res Treat.
- 2017 Jul;49(3):778-789.
- doi: 10.4143/crt.2015.485
PURPOSE: The purpose of this study was to observe the effects of metformin on human esophageal cancer cell and to investigate its possible mechanisms. MATERIALS AND METHODS: Cell viability was detected... -
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- Prognostic Influence of BCL2 on Molecular Subtypes of Breast Cancer
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Hwang KT, Han W, Kim J, Moon HG, Oh S, Song YS, Kim YA, Chang MS, Noh DY
- KMID: 2379399
- J Breast Cancer.
- 2017 Mar;20(1):54-64.
- doi: 10.4048/jbc.2017.20.1.54
PURPOSE: We aimed to reveal the prognostic influence of B-cell CLL/lymphoma 2 (BCL2) on molecular subtypes of breast cancer. METHODS: We analyzed 9,468 patients with primary breast cancer. We classified molecular... -
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- Anti-proliferative Effects of Androctonus amoreuxi Scorpion and Cerastes cerastes Snake Venoms on Human Prostate Cancer Cells
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Akef H, Kotb N, Abo-Elmatty D, Salem S
- KMID: 2375547
- J Cancer Prev.
- 2017 Mar;22(1):40-46.
- doi: 10.15430/JCP.2017.22.1.40
The present study evaluated the effects of Androctonus amoreuxi scorpion venom, Cerastes cerastes snake venom and their mixture on prostate cancer cells (PC3). An MTT assay was used to determine... -
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- Apoptotic Effect of Macrophages against Mycobacterium tuberculosis
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Kim LH, Shin SJ
- KMID: 2366879
- J Bacteriol Virol.
- 2016 Dec;46(4):312-318.
- doi: 10.4167/jbv.2016.46.4.312
Mycobacterium tuberculosis (Mtb) causing tuberculosis as an intracellular pathogen initially infects alveolar macrophages following aerosol inhalation. Thus, macrophages play a critical role in the establishment of Mtb infection and macrophage... -
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- The p90rsk-mediated signaling of ethanol-induced cell proliferation in HepG2 cell line
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Kim HS, Kim SJ, Bae J, Wang Y, Park SY, Min YS, Je HD, Sohn UD
- KMID: 2364263
- Korean J Physiol Pharmacol.
- 2016 Nov;20(6):595-603.
- doi: 10.4196/kjpp.2016.20.6.595
Ribosomal S6 kinase is a family of serine/threonine protein kinases involved in the regulation of cell viability. There are two subfamilies of ribosomal s6 kinase, (p90rsk, p70rsk). Especially, p90rsk is... -
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- Effects of Bevacizumab on Bcl-2 Expression and Apoptosis in Retinal Pigment Epithelial Cells under Oxidative Stress
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Kim S, Kim YJ, Kim NR, Chin HS
- KMID: 2363851
- Korean J Ophthalmol.
- 2015 Dec;29(6):424-432.
- doi: 10.3341/kjo.2015.29.6.424
PURPOSE: To evaluate the effects of bevacizumab on expression of B-cell leukemia/lymphoma (Bcl)-2 and apoptosis in retinal pigment epithelial (RPE) cells under oxidative stress conditions. METHODS: RPE cells were treated with... -
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- Neuroprotective Effect of Resveratrol on Acute Brain Ischemia Reperfusion Injury by Measuring Annexin V, p53, Bcl-2 Levels in Rats
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Kizmazoglu C, Aydin HE, Sevin IE, Kalemci O, Yuceer N, Atasoy MA
- KMID: 2151151
- J Korean Neurosurg Soc.
- 2015 Dec;58(6):508-512.
- doi: 10.3340/jkns.2015.58.6.508
BACKGROUND: Cerebral ischemia is as a result of insufficient cerebral blood flow for cerebral metabolic functions. Resveratrol is a natural phytoalexin that can be extracted from grape's skin and had... -
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- Effects of Repetitive Transcranial Magnetic Stimulation on Behavioral Recovery during Early Stage of Traumatic Brain Injury in Rats
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Yoon KJ, Lee YT, Chung PW, Lee YK, Kim DY, Chun MH
- KMID: 2344185
- J Korean Med Sci.
- 2015 Oct;30(10):1496-1502.
- doi: 10.3346/jkms.2015.30.10.1496
Repetitive transcranial magnetic stimulation (rTMS) is a promising technique that modulates neural networks. However, there were few studies evaluating the effects of rTMS in traumatic brain injury (TBI). Herein, we... -
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