Skip Navigation
Skip to contents
Results by Year

View Wide

Filter

ARTICLE TYPE

more+
SELECT FILTER
 
Close

PUBLICATION DATE

50 results
Display

Lovastatin derivative dehydrolovastatin ameliorates ulcerative colitis in mice by suppressing NF-κB and inflammatory cytokine expression

Zhang X, Deng QH, Deng JH, Wang SJ, Chen Q

Ulcerative colitis (UC) is associated with intestinal immune imbalance and inflammatory response. Because dehydrolovastatin (DLVT), a derivative of lovastatin, has been recently shown to inhibit inflammation and relieve immune arthritis...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Comparison of Transforming Growth Factor-Beta1 and Lovastatin on Differentiating Mesenchymal Stem Cells toward Nucleus Pulposus-like Phenotype: An In Vitro Cell Culture Study

Yang SH, Yang KC, Chen CW, Huang TC, Sun YH, Hu MH

STUDY DESIGN: In Vitro cell culture study. PURPOSE: This study aims to investigate the impact of transforming growth factor-beta1 (TGF-β1) and lovastatin on differentiating human mesenchymal stem cells (MSCs) toward nucleus...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Genome Shuffling of Mangrove Endophytic Aspergillus luchuensis MERV10 for Improving the Cholesterol-Lowering Agent Lovastatin under Solid State Fermentation

El-Gendy M, Al-Zahrani HAA, El-Bondkly AMA

In the screening of marine mangrove derived fungi for lovastatin productivity, endophytic Aspergillus luchuensis MERV10 exhibited the highest lovastatin productivity (9.5 mg/gds) in solid state fermentation (SSF) using rice bran....
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Anti-atherosclerotic effects of perilla oil in rabbits fed a high-cholesterol diet

Cha Y, Jang JY, Ban YH, Guo H, Shin K, Kim TS, Lee SP, Choi J, An ES, Seo DW, Yon JM, Choi EK, Kim YB

Anti-atherosclerosis effects of perilla oil were investigated, in comparison with lovastatin, in rabbits fed a high-cholesterol diet (HCD). Hypercholesterolemia was induced in rabbits by feeding the HCD containing 0.5% cholesterol...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Development of a validated liquid chromatography-tandem mass spectrometry assay for the quantification of simvastatin acid, the active metabolite of simvastatin, in human plasma

Park HJ, Hwang AK, Kim AR, Kim SH, Kim EH, Cho SH, Ghim JL, Choe S, Jung JA, Jin SJ, Bae KS, Lim HS

Simvastatin is a lipid-lowering drug that is metabolized to its active metabolite simvastatin acid (SA). We developed and validated a sensitive liquid chromatography-tandem mass spectrometry (LC/MS/MS) method to quantitate SA...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Oral Lovastatin Attenuates Airway Inflammation and Mucus Secretion in Ovalbumin-Induced Murine Model of Asthma

Liou CJ, Cheng PY, Huang WC, Chan CC, Chen MC, Kuo ML, Shen JJ

PURPOSE: Lovastatin is an effective inhibitor of cholesterol synthesis. A previous study demonstrated that lovastatin can also suppress airway hyperresponsiveness (AHR) in murine model of asthma. We aimed to investigate...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Cholesterol Lowering Effects of Low-dose Statins in Korean Patients

Kwon JE, Kim Y, Hyun S, Won H, Shin SY, Lee KJ, Kim SW, Kim TH, Kim CJ

OBJECTIVE: The aim of this study is to compare cholesterol lowering effects of low dose 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) in Korean patients. METHODS: A total of 909 consecutive patients...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Effect of Statins on C-reactive Protein, Lipoprotein(a) and Fibrinogen in Hypercholesterolemic Patients

Cho JH, Kim KJ, Lee WS, Lee KJ, Kim SW, Kim TH, Kim CJ

OBJECTIVE: C-reactive protein (CRP), lipoprotein (a)[Lp(a)], and fibrinogen are associated with systemic inflammatory reactions. Statins have anti-inflammatory effects. However, the effect of statins on these parameters is inconsistent. We evaluated...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Anti-hypercholesterolemic and anti-atherosclerotic effects of polarized-light therapy in rabbits fed a high-cholesterol diet

Park D, Kyung J, Kim D, Hwang SY, Choi EK, Kim YB

  • KMID: 2312091
  • Lab Anim Res.
  • 2012 Mar;28(1):39-46.
The effects of polarized-light therapy (PLT) on high-cholesterol diet (HCD)-induced hypercholesterolemia and atherosclerosis were investigated in comparison with that of lovastatin in rabbits. Hypercholesterolemia was induced by feeding male New...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
HMG CoA Reductase Inhibitors Inhibit HCV RNA Replication of HCV Genotype 1b but Not 2a

Chang KS, Jo HJ

Replication of hepatitis C virus (HCV) is regulated by statin, one of 3-hydroxy-3-methylglutaryl CoA reducatase (HMG CoA reductase) inhibitors that block mevalonate pathway and cholesterol biosyntheis, which has been used...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Factors Affecting Production of C-reactive Protein in Vascular Smooth Muscle Cells

Kim SJ, Ryu DR, Kang DH, Choi KB

  • KMID: 1465933
  • Korean J Nephrol.
  • 2009 May;28(3):173-179.
PURPOSE:The stenosis of vascular access for hemodialysis is caused by neointimal hyperplasia with the proliferation of vascular smooth muscle cells (SMC) as a prominent feature. C-reactive protein (CRP) is known...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
The Effect of Red-Yeast-Rice Supplement on Serum Lipid Profile and Glucose Control in Subjects with Impaired Fasting Glucose or Impaired Glucose Tolerance

Kang MR, Kim JY, Hyun YJ, Kim HJ, Yeo HY, Song YD, Lee JH

  • KMID: 2261193
  • Korean J Nutr.
  • 2008 Jan;41(1):31-40.
This study was aimed at evaluating the effect of red-yeast-rice supplementation on cholesterol-lowering and glucose control in subjects with impaired fasting glucose (IFT) or impaired glucose tolerance (IGT). We conducted...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Effects of lovastatin on free fatty acid oxidation in human skeletal muscle cells

Kim DL, Song KH, Kim SK, Kim HR, Ciaraldi T, Henry RR

  • KMID: 2081277
  • Korean J Med.
  • 2007 Jun;72(6):600-606.
BACKGROUDN: Recent clinical studies have suggested that statins improve insulin resistance and glucose metabolism in the skeletal muscle of diabetic patients. To evaluate a possible component of this action, we...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Effects of Lovastatin on Free Fatty Acid Oxidation in Cultured L6 Rat Skeletal Muscle Cells

Kim DL, Song KH, Kim HR, Kim SK

BACKGROUND: Recent clinical studies suggest that statins improve insulin resistance and glucose metabolism in patients with metabolic syndrome and type 2 diabetes. To evaluate the possible mechanism of this action,...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Characterization of RhoA-mediated Chemoresistance in Gastric Cancer Cells

Kang WK, Lee I, Park C

  • KMID: 1804580
  • Cancer Res Treat.
  • 2005 Aug;37(4):251-256.
PURPOSE: RhoA is a critical transducer of extracellular signals, which leads to organization of actin cytoskeleton, motility, adhesion and gene regulation. The present study aimed to explore whether RhoA influences...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Rhabdomyolysis in a Cyclosporine-treated Renal Transplant Recipient Who Received Atorvastatin as Replacement for Fluvastatin

Lee WB, Park JW, Song MS, Park MY, Cho YK, Jeung BY, Gil HW, Yang JO, Lee EY, Hong SY

  • KMID: 2307273
  • Korean J Nephrol.
  • 2004 Sep;23(5):836-839.
Statin-induced rhabdomyolysis is a frequent complication in renal transplant recipients receiving cyclosporine, but incidences are different between different types of statins. Statins have different pharmacokinetic properties. Atorvsatatin, simvastatin, lovastatin, and...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Effect of Hydroxymethyl Glutaryl Coenzyme A Reductase Inhibitor on High Sensitivity C-Reactive Protein Levels in Hypercholesterolemic Patients without Atherosclerotic Diseases

Jung KS, Lee KE, Lee SH, Kim SJ, Lee KJ, Kim SW, Kim TH, Ko HS, Kim CJ, Ryu WS, Park AJ

BACKGROUND AND OBJECTIVES: High C-reactive protein (CRP) levels are associated with an increased risk of cardiovascular diseases. The hydroxymethyl glutaryl Coenzyme A reductase inhibitors (statin) lowers the CRP level in...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Role of p53 and p38 MAPK on Doxorubicin and Lovastatin-induced Apoptosis in Colon Cancer Cells

Park WC, Lee JK, Pak RK

  • KMID: 2209881
  • J Korean Surg Soc.
  • 2003 Oct;65(4):267-278.
PURPOSE: Apoptosis plays a central role in tumor development and it has been hypothesized that lack or failure of apoptosis leads to the development of tumors, including colon cancers. Anticancer...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Influence of HMG-CoA Reductase Inhibitors on Bone Mass in Postmenopausal Women

Lee SY, Kim YJ

  • KMID: 2294818
  • J Korean Acad Fam Med.
  • 2003 May;24(5):451-455.
BACKGROUNG: It is controversial whether the use of HMG CoA reductase inhibitors (statins) is associated with an increased bone mineral density (BMD) in humans. The purpose of this study was...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Statin inhibits interferon-gamma-induced expression of intercellular adhesion molecule-1 (ICAM-1) in vascular endothelial and smooth muscle cells

Chung HK, Lee IK, Kang HK, Suh JM, Kim H, Park KC, Kim DW, Kim YK, Ro HK, Shong MH

  • KMID: 1121099
  • Exp Mol Med.
  • 2002 Dec;34(6):451-461.
Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, known as statins, are widely used for primary and secondary prevention of coronary artery atherosclerosis. Pathogenesis of atherosclerosis is multistep processes where...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close

Go to Top

Copyright © 2022 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr