- Effect of Lovastatin on Serum Lipids in Primary Hypercholesterolemia
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Park WH, Kim SW, Woo EJ, Kang SW, Hwang JY, Chae SC, Jun JE
- KMID: 2093278
- Korean Circ J.
- 1991 Apr;21(2):322-327.
- doi: 10.4070/kcj.1991.21.2.322
10 Patients with primary hypercholesterolemia were treated for 12 weeks with lovastation(20mg t.i.d). Lovastatin reduced mean total and low density lipoprotein cholesterol by 43% and 57% respectively(p -
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- Effects of Lovastatin in Combination with 5-FU on Stomach Cancer Cells
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Park C, Kang WK
- KMID: 2059145
- J Korean Cancer Assoc.
- 1997 Oct;29(5):785-790.
No abstract available -
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- The Effect of Lovastatin(Mevacor(R)) in Patients with Hypercholesterolemia
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Lee SY, Kyoung CS, Kim DC, Lee KH, Choi SJ, Son I, Park SH
- KMID: 2093279
- Korean Circ J.
- 1991 Apr;21(2):328-336.
- doi: 10.4070/kcj.1991.21.2.328
Lovastatin is a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, which catalyzes the conversion of hydroxymethylglutaryl-coenzyme A to mevalonate, anearly and rate-limiting step in the synthesis of cholesterol. We studied... -
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- The effects of lovastatin on puromycin aminonucleoside-induced focal segmental glomerulosclerosis in rats
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Kim MJ, Choi IJ
- KMID: 1694942
- Korean J Nephrol.
- 1991 Dec;10(4):492-504.
No abstract available. -
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- Effects of lovastatin on serum lipids of patients with primary hypercholesterolemia
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Kim KS, Kim JH, Lim HK, Lee BH, Lee JK
- KMID: 1691757
- Korean J Crit Care Med.
- 1993 Jun;8(1):7-11.
No abstract available. -
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- Effects of Lovastatin(Mevacor(R)) on Lowering Plasma Lipids in Patients with Hyperlipidemia
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Lee HJ, Min CH, Choi KS, Ryu WS, Ryoo UH
- KMID: 2229169
- Korean Circ J.
- 1991 Aug;21(4):781-785.
- doi: 10.4070/kcj.1991.21.4.781
Lovastatin, a competitive inhibitor of the rate limiting enzyme in cholesterol biosynthesis was administered to 34 patients with primary hypertlipidemia, 20 mg once daily with the evening meal. Patients experienced... -
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- Ichthysiform Skin Eruptions Possibly Due to Lovastatin(Mevacor)
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Park JH, Oh KS, Lee HJ, Whang KU
- KMID: 2303407
- Korean J Dermatol.
- 1999 Apr;37(4):535-537.
Lovastatin(Mevacor) belongs to a new generation of potent drugs for the treatment of hypercho- lesterolemia. It acts by competitive inhibition of 3-hydroxyl-3-methylglutaryl coenzyme A(HMG-CoA) reductase, diminishing in that way the... -
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- Antiproliferative Effect of Lovastatin on Vascular Smooth Muscle Cell
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Park SW, Kim DK, Huh JE, Choi YH, Choi YH, Gwon HC, Kim JS, Lee SH, Hong KP, Park JE, Seo JD, Lee WR
- KMID: 1858312
- Korean Circ J.
- 1998 Dec;28(12):1981-1992.
- doi: 10.4070/kcj.1998.28.12.1981
BACKGROUND AND OBJECTIVES: This study was performed to investigate the antiproliferative effect of lovastatin on vascular smooth muscle cell, especially to determine whether lovastatin induces apoptosis in vascular smooth muscle... -
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- The Preventive Effects of Bcl-2 and Bcl-xL on Lovastatin-induced Apoptosis of C6 Glial Cells
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Choi JW, Lee JM, Oh YJ
- KMID: 2285257
- Korean J Physiol Pharmacol.
- 2002 Oct;6(5):235-240.
It has been reported that lovastatin induced cell death and suppressed proliferation in various cell lines. In this study, we examined whether the cytotoxic effects of lovastatin could be prevented... -
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- The Effect of Lovastatin(Mevacor(R)) on Serum Lipids of Patients with Hypercholesterolemia
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Lee WK, Yoon J, Jang YS, Cho SY, Shim WH, Kim SS, Chung N
- KMID: 2229142
- Korean Circ J.
- 1991 Jun;21(3):567-572.
- doi: 10.4070/kcj.1991.21.3.567
We evaluated the hypolipidemic effect and adverse reaction of Lovastatin, HMG-CoA reductase inhibitor 20 to 40mg once-daily in the evening, in 20 patients with primary hypercholesterolemia for 12 weeks and... -
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- The Effect of Lovastatin(Mevacor(R)) on Serum Lipid of Patient with Noninsulin Dependent Diabetes Mellitus
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Shin GJ, Kyung NH
- KMID: 2052640
- Ewha Med J.
- 1991 Sep;14(3):217-222.
- doi: 10.12771/emj.1991.14.3.217
Patient with noninsulin dependent diabetes mellitus(NIDDM) have a major risk factor of the coronary herat disease which is important cause of death in NIDDM patients. In addition, they have relatively... -
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- Three Cases of Lovastatin Induced Rhabdomyolysis Following Renal Transplantation
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Kim YH, Kim HJ, Lee G, Choi CW, Lee TW, Ihm CG, Kim MJ
- KMID: 2198988
- J Korean Soc Transplant.
- 2001 Dec;15(2):246-250.
In renal transplantation, cardiovascular disease is a frequent cause of mortality and morbidity. Post-transplant lipoprotein abnormalities may contribute to the development of cardiovascular disease and chronic renal allograft rejection. Post-... -
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- Hypolipidemic Effects and Safety of Lovastatin in Patients with Primary Hypercholesterolemia
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Bae JH, Choue CW, Kim KS, Kim MS, Song JS
- KMID: 2229127
- Korean Circ J.
- 1991 Feb;21(1):129-136.
- doi: 10.4070/kcj.1991.21.1.129
To evaluate the efficacy and safety of lovastatin, new hypolipidemic agent of HMG-CoA reductase inhibitor, we administered lovastatin 40mg to 80mg once daily for 12 weeks in 20 patients(7 males,... -
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- A Case of Acquired Ichthyosis Developed During Cholesterol-lowering Treatment
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Jeong SJ, Kim YT
- KMID: 2303472
- Korean J Dermatol.
- 1997 Jun;35(3):546-550.
A 42-year-old woman presented with ichthyosiform eruptions on her trunk and buttock which developed 20 days prior to consulatation. She had taken the cholesterol-lowering drug(lovastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG CoA)... -
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- Genome Shuffling of Mangrove Endophytic Aspergillus luchuensis MERV10 for Improving the Cholesterol-Lowering Agent Lovastatin under Solid State Fermentation
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El-Gendy M, Al-Zahrani HAA, El-Bondkly AMA
- KMID: 2354754
- Mycobiology.
- 2016 Sep;44(3):171-179.
- doi: 10.5941/MYCO.2016.44.3.171
In the screening of marine mangrove derived fungi for lovastatin productivity, endophytic Aspergillus luchuensis MERV10 exhibited the highest lovastatin productivity (9.5 mg/gds) in solid state fermentation (SSF) using rice bran.... -
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- Effect of Lovastatin(Mevacor(R)) on Serum Lipids of Patients with Primary Hyperlipidemia
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Yoo WS, Lee SB, Ahn JH, Kim K, Lee DC, Rhee KJ, Choi SK
- KMID: 1938159
- Korean Circ J.
- 1989 Sep;19(3):489-496.
- doi: 10.4070/kcj.1989.19.3.489
A new hypolipidemic agent, lovastatin, hydroxy-methyl-gultaryl coenzyme A reductase inhibitor was administred to 25 patients with primary hyperlipidemia 20 to 40 mg daily for 12 weeks and sequential changes of... -
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- Antiatherogenic Effect of Naringin Independent of Lipid-Lowering Action in Hypercholesterolemic Rabbits
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Choe SC, Kim HS, Jeong TS, Bok SH, Park YB
- KMID: 1858299
- Korean Circ J.
- 1998 Nov;28(11):1873-1881.
- doi: 10.4070/kcj.1998.28.11.1873
BACKGROUND: Naringin, one of the flavonoids in citrus fruit peels, is known to have antioxidant and hepatotonic effects in animal studies. We evaluated the effect of naringin on 1) blood... -
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- Clinical Efficacy of Lovastatin in Patients with Hypercholesterolemia
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Kim JS, Chai IH, Park SW, Hong SK, Kim HS, Kim CH, Sohn DW, Oh BH, Lee MM, Park YB, Choi YS, Seo JD, Lee YW
- KMID: 2093362
- Korean Circ J.
- 1992 Feb;22(1):121-129.
- doi: 10.4070/kcj.1992.22.1.121
BACKGROUND: This study was designed to evaluate the clinical efficasy of lovastatin, HMG-CoA reductase inhibitor, in patients with hypercholesterolemia. METHODS AND RESULTS: Lovastatin 20 to 80 mg were administered once daily... -
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- Effects of Lovastatin on Free Fatty Acid Oxidation in Cultured L6 Rat Skeletal Muscle Cells
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Kim DL, Song KH, Kim HR, Kim SK
- KMID: 1523011
- J Korean Diabetes Assoc.
- 2007 May;31(3):230-235.
- doi: 10.4093/jkda.2007.31.3.230
BACKGROUND: Recent clinical studies suggest that statins improve insulin resistance and glucose metabolism in patients with metabolic syndrome and type 2 diabetes. To evaluate the possible mechanism of this action,... -
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- The effect of lovastatin on proliferation of cultured rat mesangial and aortic smooth muscle cells
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Choi KH, Kang SW, Lee SW, Lee HY, Han DS, Kang BS
- KMID: 1123180
- Yonsei Med J.
- 1995 Jun;36(3):251-261.
- doi: 10.3349/ymj.1995.36.3.251
In order to investigate the anti-proliferative effect of 3-hydroxy-3-methylglutaryl coenzyme. A reductase inhibitor, we evaluated the effects of lovastatin on DNA replication and the proliferation of rat mesangial and aortic... -
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