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Lovastatin derivative dehydrolovastatin ameliorates ulcerative colitis in mice by suppressing NF-κB and inflammatory cytokine expression

Zhang X, Deng QH, Deng JH, Wang SJ, Chen Q

Ulcerative colitis (UC) is associated with intestinal immune imbalance and inflammatory response. Because dehydrolovastatin (DLVT), a derivative of lovastatin, has been recently shown to inhibit inflammation and relieve immune arthritis...
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Comparison of Transforming Growth Factor-Beta1 and Lovastatin on Differentiating Mesenchymal Stem Cells toward Nucleus Pulposus-like Phenotype: An In Vitro Cell Culture Study

Yang SH, Yang KC, Chen CW, Huang TC, Sun YH, Hu MH

STUDY DESIGN: In Vitro cell culture study. PURPOSE: This study aims to investigate the impact of transforming growth factor-beta1 (TGF-β1) and lovastatin on differentiating human mesenchymal stem cells (MSCs) toward nucleus...
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Genome Shuffling of Mangrove Endophytic Aspergillus luchuensis MERV10 for Improving the Cholesterol-Lowering Agent Lovastatin under Solid State Fermentation

El-Gendy M, Al-Zahrani HAA, El-Bondkly AMA

In the screening of marine mangrove derived fungi for lovastatin productivity, endophytic Aspergillus luchuensis MERV10 exhibited the highest lovastatin productivity (9.5 mg/gds) in solid state fermentation (SSF) using rice bran....
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Oral Lovastatin Attenuates Airway Inflammation and Mucus Secretion in Ovalbumin-Induced Murine Model of Asthma

Liou CJ, Cheng PY, Huang WC, Chan CC, Chen MC, Kuo ML, Shen JJ

PURPOSE: Lovastatin is an effective inhibitor of cholesterol synthesis. A previous study demonstrated that lovastatin can also suppress airway hyperresponsiveness (AHR) in murine model of asthma. We aimed to investigate...
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Anti-hypercholesterolemic and anti-atherosclerotic effects of polarized-light therapy in rabbits fed a high-cholesterol diet

Park D, Kyung J, Kim D, Hwang SY, Choi EK, Kim YB

  • KMID: 2312091
  • Lab Anim Res.
  • 2012 Mar;28(1):39-46.
The effects of polarized-light therapy (PLT) on high-cholesterol diet (HCD)-induced hypercholesterolemia and atherosclerosis were investigated in comparison with that of lovastatin in rabbits. Hypercholesterolemia was induced by feeding male New...
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Role of p53 and p38 MAPK on Doxorubicin and Lovastatin-induced Apoptosis in Colon Cancer Cells

Park WC, Lee JK, Pak RK

  • KMID: 2209881
  • J Korean Surg Soc.
  • 2003 Oct;65(4):267-278.
PURPOSE: Apoptosis plays a central role in tumor development and it has been hypothesized that lack or failure of apoptosis leads to the development of tumors, including colon cancers. Anticancer...
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The Preventive Effects of Bcl-2 and Bcl-xL on Lovastatin-induced Apoptosis of C6 Glial Cells

Choi JW, Lee JM, Oh YJ

  • KMID: 2285257
  • Korean J Physiol Pharmacol.
  • 2002 Oct;6(5):235-240.
It has been reported that lovastatin induced cell death and suppressed proliferation in various cell lines. In this study, we examined whether the cytotoxic effects of lovastatin could be prevented...
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Effect of long-term 3-hydroxy 3-methyl glutaryl CoA reductase inhibitor therapy on lipoprotein (a) concentration

Ahn JH, Lee SY, Cho SW, Kim SM, Song YB, Lee KJ, Kim SW, Ko HS, Kim TH, Kim CJ, RyuKim WS

  • KMID: 2252841
  • Korean J Med.
  • 2002 Sep;63(3):283-289.
BACKGROUND: The effect of 3-hydroxy 3-methyl glutaryl CoA reductase inhibitor (statin) on the concentration of lipoprotein (a) [Lp(a)] is controversial. Most studies evaluated the effect of statin administered for less...
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Three Cases of Lovastatin Induced Rhabdomyolysis Following Renal Transplantation

Kim YH, Kim HJ, Lee G, Choi CW, Lee TW, Ihm CG, Kim MJ

  • KMID: 2198988
  • J Korean Soc Transplant.
  • 2001 Dec;15(2):246-250.
In renal transplantation, cardiovascular disease is a frequent cause of mortality and morbidity. Post-transplant lipoprotein abnormalities may contribute to the development of cardiovascular disease and chronic renal allograft rejection. Post-...
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Effect of Enalapril or Lovastatin on Tubulointerstitial Injury Induced by Protein-overload Proteinuria in Rats

Chung SJ, Chung JG, Yang WS, Kim SB, Park SK, Lee SK, Park JS

  • KMID: 1989745
  • Korean J Nephrol.
  • 2001 May;20(3):393-402.
BACKGROUND: Previous studies have demonstrated that enalapril or lovastatin seems to ameliorate the renal injury in several animal models with glomerulonephritis. The aim of this study was to examine whether...
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The effects on serum lipoprotein(a) of antihyperlipidemic agents

Kim KT, Park SJ, Suh YS, Kim DH, Shin DH

  • KMID: 2295267
  • J Korean Acad Fam Med.
  • 2000 Feb;21(2):234-243.
BACKGROUND: Many studies to reduce serum lipoprotein(a) are done because serum lipoprotein(a) has been known to be an independent risk factor of coronary artery disease along with age, smoking, diabetes,...
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Effect of Local Administration of Lovastatin on Preventing Neointimal Hyperplasia in the Rat Carotid Artery Injury Model

Lee SC, Kim DK, Park SW, Huh JE, Park SJ, Gwon HC, Kim JS, Lee SH, Hong KP, Park JE, Seo JD, Lee WR

BACKGROUND AND OBJECTIVES: ovastatin, a HMG-CoA reductase inhibitor, is known to show antiproliferative effects on VSMC after vessel injury, but a large amount of the drug is needed orally for...
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Effect of Local Administration of Lovastatin on Preventing Neointimal Hyperplasia in the Rat Carotid Artery Injury Model

Hwang GS, Kim YH, Lee HS, Kim BS, Lee SJ, Pak HN, Lim DS, Park CG, Seo HS, Shim WJ, Oh DJ, Ro YM

BACKGROUND AND OBJECTIVES: ovastatin, a HMG-CoA reductase inhibitor, is known to show antiproliferative effects on VSMC after vessel injury, but a large amount of the drug is needed orally for...
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Ichthysiform Skin Eruptions Possibly Due to Lovastatin(Mevacor)

Park JH, Oh KS, Lee HJ, Whang KU

  • KMID: 2303407
  • Korean J Dermatol.
  • 1999 Apr;37(4):535-537.
Lovastatin(Mevacor) belongs to a new generation of potent drugs for the treatment of hypercho- lesterolemia. It acts by competitive inhibition of 3-hydroxyl-3-methylglutaryl coenzyme A(HMG-CoA) reductase, diminishing in that way the...
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Antiproliferative Effect of Lovastatin on Vascular Smooth Muscle Cell

Park SW, Kim DK, Huh JE, Choi YH, Choi YH, Gwon HC, Kim JS, Lee SH, Hong KP, Park JE, Seo JD, Lee WR

BACKGROUND AND OBJECTIVES: This study was performed to investigate the antiproliferative effect of lovastatin on vascular smooth muscle cell, especially to determine whether lovastatin induces apoptosis in vascular smooth muscle...
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The Frequency Distribution of Apolipoprotein E Genetic Polymorphism and Relationship of Apolipoprotein E Genetic Polymorphism with Development of Coronary Artery Disease in Patients with Familial Hypercholesterolemia

Han KH, Choe SC, Kim SY, Chae IH, Kim HS, Sohn DW, Oh BH, Lee MM, Park YB, Choi YS, Lee YW

  • KMID: 1558490
  • Korean J Med.
  • 1998 Dec;55(6):1039-1048.
OBJECTIVES: Apolipoprotein E genetic polymorphism was screened in subjects with FH to determine the genetic effects of Apo E polymorphism on basal cholesterol levels, severity of coronary atherosclerosis and response...
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Effects of Lovastatin in Combination with 5-FU on Stomach Cancer Cells

Park C, Kang WK

  • KMID: 2059145
  • J Korean Cancer Assoc.
  • 1997 Oct;29(5):785-790.
No abstract available
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A Case of Acquired Ichthyosis Developed During Cholesterol-lowering Treatment

Jeong SJ, Kim YT

  • KMID: 2303472
  • Korean J Dermatol.
  • 1997 Jun;35(3):546-550.
A 42-year-old woman presented with ichthyosiform eruptions on her trunk and buttock which developed 20 days prior to consulatation. She had taken the cholesterol-lowering drug(lovastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG CoA)...
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Clinical Efficacy of Lovastatin in Patients with Hypercholesterolemia

Kim JS, Chai IH, Park SW, Hong SK, Kim HS, Kim CH, Sohn DW, Oh BH, Lee MM, Park YB, Choi YS, Seo JD, Lee YW

BACKGROUND: This study was designed to evaluate the clinical efficasy of lovastatin, HMG-CoA reductase inhibitor, in patients with hypercholesterolemia. METHODS AND RESULTS: Lovastatin 20 to 80 mg were administered once daily...
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Effects of Lovastatin(Mevacor(R)) on Lowering Plasma Lipids in Patients with Hyperlipidemia

Lee HJ, Min CH, Choi KS, Ryu WS, Ryoo UH

Lovastatin, a competitive inhibitor of the rate limiting enzyme in cholesterol biosynthesis was administered to 34 patients with primary hypertlipidemia, 20 mg once daily with the evening meal. Patients experienced...
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