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Epi-Leptosphaerin: A New L-Isoascorbic Acid Derivative from Marine Sponges

Kulkarni R, Jo AR, Kim YH, Na M

  • Nat Prod Sci.
  • 2015 Dec;21(4):293-296.
  • doi: 10.20307/nps.2015.21.4.293
A new L-isoascorbic acid derivative epi-leptosphaerin (1) and two known compounds leptosphaerin (2), and verongamine (3) were isolated from sponges of the orders Verongida and Thorectidae. Compounds 1 and 2...
Two New Scalaranes from a Korean Marine Sponge Spongia sp.

Yang I, Nam SJ, Kang H

  • Nat Prod Sci.
  • 2015 Dec;21(4):289-292.
  • doi: 10.20307/nps.2015.21.4.289
Intensive chemical investigation of Korean marine sponge Spongia sp. has led to the isolation of two new scalaranes. The planar structures of the new compounds 1 and 2 were determined...
Viriditoxin Induces G2/M Cell Cycle Arrest and Apoptosis in A549 Human Lung Cancer Cells

Park JH, Noh TH, Wang H, Kim ND, Jung JH

  • Nat Prod Sci.
  • 2015 Dec;21(4):282-288.
  • doi: 10.20307/nps.2015.21.4.282
Viriditoxin is a fungal metabolite isolated from Paecilomyces variotii, which was derived from the giant jellyfish Nemopilema nomurai. Viriditoxin was reported to inhibit polymerization of FtsZ, which is a key...
A Novel Bromoindole Alkaloid from a Korean Colonial Tunicate Didemnum sp.

Hahn D, Kim GJ, Choi H, Kang H

  • Nat Prod Sci.
  • 2015 Dec;21(4):278-281.
  • doi: 10.20307/nps.2015.21.4.278
Chemical investigation on a colonial marine tunicate, Didemnum sp. led to the isolation of a series of indole alkaloids including a new (1) and two known metabolites (2-3). Based on...
Salternamide E from a Saltern-derived Marine Actinomycete Streptomyces sp.

Kim SH, Shin Y, Lee SK, Shin J, Oh DC

  • Nat Prod Sci.
  • 2015 Dec;21(4):273-277.
  • doi: 10.20307/nps.2015.21.4.273
Comprehensive chemical analysis of extracts and fractions of marine actinomycete strains led to the discovery of a new minor secondary metabolite, salternamide E (1), from a saltern-derived halophilic Streptomyces strain....
Anti-inflammatory Effect of Dactyloquinone B and Cyclospongiaquinone-1 Mixture in RAW264.7 Macrophage and ICR Mice

Lee DS, Hwang IH, Im NK, Jeong GS, Na M

  • Nat Prod Sci.
  • 2015 Dec;21(4):268-272.
  • doi: 10.20307/nps.2015.21.4.268
Sesquiterpene-quinone is a class of secondary metabolites frequently encountered from marine sponge. The present study was designed to examine the anti-inflammatory action of sponge-derived dactyloquinone B (DQB) and cyclospongiaquinone-1 (CSQ1)...
Deuteromethylactin B from a Freshwater-derived Streptomyces sp.

Shaikh AF, Elfeki M, Landolfa S, Tanouye U, Green SJ, Murphy BT

  • Nat Prod Sci.
  • 2015 Dec;21(4):261-267.
  • doi: 10.20307/nps.2015.21.4.261
Compared to their terrestrial and marine counterparts, little is known about the capacity of freshwater-derived actinomycete bacteria to produce novel secondary metabolites. In the current study, we highlight the disparities...
Graphiumins I and J, New Thiodiketopiperazines from the Marine-derived Fungus Graphium sp. OPMF00224

Fukuda T, Nagai K, Kurihara Y, Kanamoto A, Tomoda H

  • Nat Prod Sci.
  • 2015 Dec;21(4):255-260.
  • doi: 10.20307/nps.2015.21.4.255
Two new thiodiketopiperazines (TDKPs), designated graphiumins I (1) and J (2), were isolated from the culture broth of the marine-derived fungus Graphium sp. OPMF00224 by solvent extraction, silica gel column...
Anti-Inflammatory Effect of Violapyrones B and C from a Marine-derived Streptomyces sp.

Lee HS, An BJ, Kim HJ, Cho YH, Kim DI, Jang JY, Kwak JH, Lee HS, Lee YJ, Lee JS, Shin HJ

  • Nat Prod Sci.
  • 2015 Dec;21(4):251-254.
  • doi: 10.20307/nps.2015.21.4.251
Recently, we reported violapyrones B, C, H and I, unusual 3, 4, 6-trisubstituted alpha-pyrone derivatives, from the culture broth of the marine Streptomyces sp. 112CH148. In previous studies, violapyrones have...
Violapyrone J, alpha-Pyrone Derivative from a Marine-derived Actinomycetes, Streptomyces sp.

Leutou AS, Yang I, Seong CN, Ko J, Nam SJ

  • Nat Prod Sci.
  • 2015 Dec;21(4):248-250.
  • doi: 10.20307/nps.2015.21.4.248
A new alpha-pyrone derivative, violapyrone J (1), and along with the two known violapyrones B (2) and C (3) were isolated from the fermentation broth of a marine actinomycete Streptomyces...
Viridicatol from Marine-derived Fungal Strain Penicillium sp. SF-5295 Exerts Anti-inflammatory Effects through Inhibiting NF-kappaB Signaling Pathway on Lipopolysaccharide-induced RAW264.7 and BV2 Cells

Ko W, Sohn JH, Kim YC, Oh H

  • Nat Prod Sci.
  • 2015 Dec;21(4):240-247.
  • doi: 10.20307/nps.2015.21.4.240
Viridicatol (1) has previously been isolated from the extract of the marine-derived fungus Penicillium sp. SF-5295. In the course of further biological evaluation of this quinolone alkaloid, anti-inflammatory effect of...
A New Sesterterpene from the Korean Sarcotragus sp. Sponge

Woo JK, Jeon JE, Kim B, Sim CJ, Oh DC, Oh KB, Shin J

  • Nat Prod Sci.
  • 2015 Dec;21(4):237-239.
  • doi: 10.20307/nps.2015.21.4.237
Sarcotragin C (1), a new sesterterpene metabolite was isolated from a Sarcotragus sp. sponge collected from Chuja Island, Korea. On the basis of the combined spectroscopic analyses, the structure of...
Penidioxolanes A and B, 1,3-Dioxolane Containing Azaphilone Derivatives from Marine-derived Penicillium sp. KCB12C078

Kim SM, Son S, Kim JW, Jeon ES, Ko SK, Ryoo IJ, Shin KS, Hirota H, Takahashi , Osada H, Jang JH, Ahn JS

  • Nat Prod Sci.
  • 2015 Dec;21(4):231-236.
  • doi: 10.20307/nps.2015.21.4.231
Two new azaphilone derivatives containing 1,3-dioxolane moiety, penidioxolanes A (1) and B (2), were isolated from marine-derived fungus Penicillium sp. KCB12C078, together with four known compounds (3-6) by chemical investigation....
Pestalotiolide A, a New Antiviral Phthalide Derivative from a Soft Coral-derived Fungus Pestalotiopsis sp.

Jia YL, Guan FF, Ma J, Wang CY, Shao CL

  • Nat Prod Sci.
  • 2015 Dec;21(4):227-230.
  • doi: 10.20307/nps.2015.21.4.227
Chemical investigation of the fermentation broth of a Soft Coral-Derived fungus Pestalotiopsis sp., led to the isolation of a new phthalide derivative, pestalotiolide A (1), three known analogues (2, 3...

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