Nat Prod Sci.  2015 Dec;21(4):273-277. 10.20307/nps.2015.21.4.273.

Salternamide E from a Saltern-derived Marine Actinomycete Streptomyces sp.

• Kim SH
• Shin Y
• Lee SK
• Shin J
• Oh DC

• KMID: 2312909
• DOI: http://doi.org/10.20307/nps.2015.21.4.273

Abstract

Comprehensive chemical analysis of extracts and fractions of marine actinomycete strains led to the discovery of a new minor secondary metabolite, salternamide E (1), from a saltern-derived halophilic Streptomyces strain. The planar structure of salternamide E (1) was elucidated by a combinational analysis of spectroscopic data including NMR, MS, UV, and IR. The absolute configuration of salternamide E (1) was determined by circular dichroism spectroscopic analysis. Salternamide E displayed weak cytotoxicity against various human carcinoma cell lines.

Keyword

Marine actinomycete; Saltern; LC/MS analysis; Salternamide E; Cytotoxicity

MeSH Terms

Cell Line
Circular Dichroism
Humans
Streptomyces*

Figure

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  Fig. 1. The structure of salternamide E (1).

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  Fig. 2. Key COSY () and HMBC (→) correlations of 1.

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  Fig. 3. 1H-1H coupling constants (J values) and key NOESY () correlations of 1.

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  Fig. 4. The experimental ECD spectra of 1 and salternamide C.

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