Nat Prod Sci.  2015 Dec;21(4):273-277. 10.20307/nps.2015.21.4.273.

Salternamide E from a Saltern-derived Marine Actinomycete Streptomyces sp.

Affiliations
  • 1Natural Products Research Institute, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea. dongchanoh@snu.ac.kr

Abstract

Comprehensive chemical analysis of extracts and fractions of marine actinomycete strains led to the discovery of a new minor secondary metabolite, salternamide E (1), from a saltern-derived halophilic Streptomyces strain. The planar structure of salternamide E (1) was elucidated by a combinational analysis of spectroscopic data including NMR, MS, UV, and IR. The absolute configuration of salternamide E (1) was determined by circular dichroism spectroscopic analysis. Salternamide E displayed weak cytotoxicity against various human carcinoma cell lines.

Keyword

Marine actinomycete; Saltern; LC/MS analysis; Salternamide E; Cytotoxicity
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