Nat Prod Sci.  2015 Dec;21(4):237-239. 10.20307/nps.2015.21.4.237.

A New Sesterterpene from the Korean Sarcotragus sp. Sponge

Affiliations
  • 1Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 151-742, Korea. shinj@snu.ac.kr
  • 2Department of Biological Science, College of Life Science and Nano Technology, Hannam University, Daejeon 305-811, Korea.
  • 3Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, Seoul 151-921, Korea. ohkibong@snu.ac.kr

Abstract

Sarcotragin C (1), a new sesterterpene metabolite was isolated from a Sarcotragus sp. sponge collected from Chuja Island, Korea. On the basis of the combined spectroscopic analyses, the structure of this compound was determined to be a linear norsesterterpene containing a leucine-derived gamma-lactam moiety. This compound exhibited moderate cytotoxicity against K562 and A549 cell-lines.

Keyword

Sponge; Sarcotragus sp.; Sarcotragin C; Norsesterterpene; Cytotoxicity
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