Nat Prod Sci.  2015 Dec;21(4):231-236. 10.20307/nps.2015.21.4.231.

Penidioxolanes A and B, 1,3-Dioxolane Containing Azaphilone Derivatives from Marine-derived Penicillium sp. KCB12C078

• Kim SM
• Son S
• Kim JW
• Jeon ES
• Ko SK
• Ryoo IJ
• Shin KS
• Hirota H
• Takahashi
• Osada H
• Jang JH
• Ahn JS

• KMID: 2312901
• DOI: http://doi.org/10.20307/nps.2015.21.4.231

Abstract

Two new azaphilone derivatives containing 1,3-dioxolane moiety, penidioxolanes A (1) and B (2), were isolated from marine-derived fungus Penicillium sp. KCB12C078, together with four known compounds (3-6) by chemical investigation. Compounds 1 - 6 were isolated by combination of silica gel, ODS column chromatography and preparative HPLC. Their structures were determined by analysis of spectroscopic data including 1D-, 2D-NMR, and MS techniques. The isolates were evaluated against cancer cell growth inhibition effects and antimicrobial activity.

Keyword

azaphilone derivatives; 1,3-Dioxolane; Marine-derived fungus; Penicillium

MeSH Terms

Chromatography
Chromatography, High Pressure Liquid
Fungi
Penicillium*
Silica Gel
Silica Gel

Figure

• 

  Fig. 1. Structures of isolated compounds 1 - 6.

• 

  Fig. 2. Key COSY and HMBC correlations for 1 and 2.

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  Fig. 3. NOESY correlations for 1 and 2.

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