Nat Prod Sci.  2015 Dec;21(4):231-236. 10.20307/nps.2015.21.4.231.

Penidioxolanes A and B, 1,3-Dioxolane Containing Azaphilone Derivatives from Marine-derived Penicillium sp. KCB12C078

  • 1Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk 363-883, Korea.,
  • 2Department of Biomolecular Science, University of Science and Technology, Daejeon 305-333, Korea.
  • 3RIKEN-KRIBB Joint Research Unit, Global Research Cluster, RIKEN, Saitama 351-0198, Japan.
  • 4Chemical Biology Research Group, RIKEN CSRS, Saitama 351-0198, Japan.
  • 5Microbial Resources Center, KRIBB, Daejeon 306-809, Korea.


Two new azaphilone derivatives containing 1,3-dioxolane moiety, penidioxolanes A (1) and B (2), were isolated from marine-derived fungus Penicillium sp. KCB12C078, together with four known compounds (3-6) by chemical investigation. Compounds 1 - 6 were isolated by combination of silica gel, ODS column chromatography and preparative HPLC. Their structures were determined by analysis of spectroscopic data including 1D-, 2D-NMR, and MS techniques. The isolates were evaluated against cancer cell growth inhibition effects and antimicrobial activity.


azaphilone derivatives; 1,3-Dioxolane; Marine-derived fungus; Penicillium
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