Nat Prod Sci.  2015 Dec;21(4):289-292. 10.20307/nps.2015.21.4.289.

Two New Scalaranes from a Korean Marine Sponge Spongia sp.

Affiliations
  • 1School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 151-747, Korea. hjkang@snu.ac.kr
  • 2Department of Chemistry and Nano Science, Global Top5 Program, Ewha Womans University, Seoul 120-750, Korea. sjnam@ewha.ac.kr
  • 3Research Institute of Oceanography, Seoul National University, NS-80, Seoul 151-747, Korea.

Abstract

Intensive chemical investigation of Korean marine sponge Spongia sp. has led to the isolation of two new scalaranes. The planar structures of the new compounds 1 and 2 were determined through 1D and 2D NMR spectral data analysis, while the relative stereochemistry of the compounds was determined based on the analysis of 1H-1H coupling constants and NOESY spectroscopic data. Compounds 1 and 2 did not display any significant biological activities on farnesoid X-activated receptor (FXR) in co-transfection assay.

Keyword

Scalarane; Sesterpenoid; Spongia sp.; Korean sponge; Marine natural product
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