Korean J Anesthesiol.  1991 Oct;24(5):925-930. 10.4097/kjae.1991.24.5.925.

Behamioral Change and Memory Inpairment Following Transient Forebrain Ischemia in Rats

Affiliations
  • 1Department of Anesthesiology, College of Medicine, Pusan National University, Pusan, Korea.

Abstract

This study examined the behavioral change and memory impairment following transient forebrain ischemia in 20 male rats: ten rats were subjected to sham operation. Inchemia was induced by a combination of bilateral common carotid artery occlusion and induced hypotension. During the recovery period, behavioral change was evaluated by open-field method. Histopathological examination was performed 7 days after ischemic insult. The results were as follows 1) Hippocampus CA 1 neuron was the most vulnerable to 10-minute forebrain ischemia. 2) There was increase in locomotor activity and rearing during early post-ischemic period. 3) Ischemia resulted in suppressed preening and grooming. From the above mentioned results, authors suggested that transient forebrain ischemia produced severe neuronal damage in CA l sector of hippocampus, therefore produced behavioral change and memory impairment.

Keyword

Transient forebrain ischemia; Open field test

MeSH Terms

Animals
Carotid Artery, Common
Grooming
Hippocampus
Humans
Hypotension
Ischemia*
Male
Memory*
Motor Activity
Neurons
Prosencephalon*
Rats*
Full Text Links
  • KJAE
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr