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The Effects of Gabapentin on Facial Formalin Test

Kim CH, Baik SW, Kim HK, Kwon JY, Kim KH, Choi SH

BACKGROUND: Gabapentin is a novel anti-epileptic drug, which is used in clinical practice to treat epilepsy. This drug is also used as an analgesic in pain patients. The antinociceptive effect...
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The Effects of Gabapentin on Facial Formalin Test

Kim CH, Baik SW, Kim HK, Kwon JY, Kim KH, Choi SH

BACKGROUND: Gabapentin is a novel anti-epileptic drug, which is used in clinical practice to treat epilepsy. This drug is also used as an analgesic in pain patients. The antinociceptive effect...
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Central Pain from Excitotoxic Spinal Cord Injury Induced by Intraspinal NMDA Injection: A Pilot Study

Leem YJ, Joh JW, Joeng KW, Suh JH, Shin JW, Leem JG

BACKGROUND: The pathophysiological and neurochemical changes following spinal injury are not yet elucidated. This study was designed to evaluate the morphological changes of the dorsal horn of the spinal cord...
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Development of Neuropathic Pain by Thermal Injury using Radiofrequency Thermocoagulation in a Rat Infraorbital Nerve

Kim SM, Kim CH, Kim HK, Shin SW

BACKGROUND: The aim of this study was to investigate the development of neuropathic pain by radiofrequency thermocoagulation on a rat infraorbital nerve (IoN). METHODS: Male Sprague-Dawley rats (n = 35) were...
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Age-Related Differences in Rehabilitation Outcome in Cervical Spinal Cord Injury Patients

Lim JY, Shin HI, Kim GR, Kim DA, Kim JY, Rha IS, Lee ES

  • KMID: 1817284
  • J Korean Geriatr Soc.
  • 2002 Sep;6(3):222-232.
BACKGROUND: The growing number of spinal cord injured individuals facing old age makes the understanding of age related limitations increasingly important. This study was to investigate the age-related differences in...
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Behamioral Change and Memory Inpairment Following Transient Forebrain Ischemia in Rats

Rho CK, Kwon JY, Kim HK, Baik SW, Kim IS, Chung KS

This study examined the behavioral change and memory impairment following transient forebrain ischemia in 20 male rats: ten rats were subjected to sham operation. Inchemia was induced by a combination...
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Effectiveness of Cognitive Training to Instrumental Activities of Daily Living in Community-Dwelling Elderly

Lee SM, Lee KH, Lee K, Kwak KP

OBJECTIVE: This study was aimed to investigate the effectiveness of cognitive training to Instrumental Activities of Daily Living (IADL) in community-dwelling elderly. METHODS: The participant were 786 elders who were aged...
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Recovery State of Hemorrhagic Stroke Patients: Exploratory Comparison of Recovery State between Spontaneous Intracerebral Hemorrhage(s-ICH) and Spontaneous Subarachnoid Hemorrhage(s-SAH)

Oh HS, Seo WS, Cho HY, Kim MO, Kim MR, Mo J

  • KMID: 2290741
  • J Korean Acad Adult Nurs.
  • 2008 Aug;20(4):600-612.
PURPOSE: This study was conducted to compare the recovery state of 6 month between s-ICH and s-SAH patients. The patients' recovery state was measured with 2 dimensions: functional and cognitive....
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Highly Palatable Food during Adolescence Improves Anxiety-Like Behaviors and Hypothalamic-Pituitary-Adrenal Axis Dysfunction in Rats that Experienced Neonatal Maternal Separation

Lee JH, Kim JY, Jahng JW

BACKGROUND: This study was conducted to examine the effects of ad libitum consumption of highly palatable food (HPF) during adolescence on the adverse behavioral outcome of neonatal maternal separation. METHODS: Male...
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Influence of Short- and Long-term High-dose Caffeine Administration on Behavior in an Animal Model of Adolescence

Park JM, Kim Y, Kim H, Kim YJ

PURPOSE: Caffeine is the most widely consumed psychostimulant of the methylxanthine class. Among adolescents, high-dose of caffeine consumption has increased rapidly over the last few decades due to the introduction...
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Comparison of the Spinal Neuropathic Pain Induced by Intraspinal Injection of N-Methyl-D-Aspartate and Quisquate in Rats

Choi SS, Hahm KD, Min HG, Leem JG

OBJECTIVE: Excitatory amino acids play important roles in the development of secondary pathology following spinal cord injury (SCI). This study was designed to evaluate morphological changes in the dorsal horn...
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Long-Term Outcomes of FIM Motor Items Predicted From Acute Stage NIHSS of Patients With Middle Cerebral Artery Infarct

Saito J, Koyama T, Domen K

OBJECTIVE: To outline the association between the National Institutes of Health Stroke Scale (NIHSS) in the acute stage and the Functional Independence Measure (FIM) of motor items several months later. METHODS:...
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L-Tetrahydropalmatine Ameliorates Development of Anxiety and Depression-Related Symptoms Induced by Single Prolonged Stress in Rats

Lee B, Sur B, Yeom M, Shim I, Lee H, Hahm DH

  • KMID: 2170639
  • Biomol Ther.
  • 2014 May;22(3):213-222.
Abnormal adaptation of the stress-response system following traumatic stress can lead to alterations in the hypothalamic-pituitary-adrenal (HPA) axis that may contribute to the development of post-traumatic stress disorder (PTSD). The...
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Early-Life Stress in D2 Heterozygous Mice Promotes Autistic-like Behaviors through the Downregulation of the BDNF-TrkB Pathway in the Dorsal Striatum

Lee Y, Han PL

A number of specific genetic variants including gene mutations and single nucleotide variations have been identified in genomewide association studies of autism spectrum disorder (ASD). ASD phenotypes in individuals carrying...
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Effects of Intraperitoneal N-methyl-D-aspartate (NMDA) Administration on Nociceptive/Repetitive Behaviors in Juvenile Mice

Kim S, Kim DG, Gonzales E, Mabunga DF, Shin D, Jeon SJ, Shin CY, Ahn T, Kwon KJ

Dysregulation of excitatory neurotransmission has been implicated in the pathogenesis of neuropsychiatric disorders. Pharmacological inhibition of N-methyl-D-aspartate (NMDA) receptors is widely used to model neurobehavioral pathologies and underlying mechanisms. There...
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Berberine alleviates symptoms of anxiety by enhancing dopamine expression in rats with post-traumatic stress disorder

Lee B, Shim I, Lee H, Hahm DH

Post-traumatic stress disorder (PTSD) is a trauma-induced psychiatric disorder characterized by impaired fear extermination, hyperarousal, anxiety, depression, and amnesic symptoms that may involve the release of monoamines in the fear...
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Tetramethylpyrazine reverses anxiety-like behaviors in a rat model of post-traumatic stress disorder

Lee B, Shim I, Lee H, Hahm DH

Post-traumatic stress disorder (PTSD) is a trauma-induced psychiatric disorder characterized by impaired fear extermination, hyperarousal, and anxiety that may involve the release of monoamines in the fear circuit. The reported...
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Effects of Combined Upper Limb Robotic Therapy in Patients With Tetraplegic Spinal Cord Injury

Jung JH, Lee HJ, Cho DY, Lim JE, Lee BS, Kwon SH, Kim HY, Lee SJ

OBJECTIVE: To confirm the effects of combined upper limb robotic therapy (RT) as compared to conventional occupational therapy (OT) in tetraplegic spinal cord injury (SCI) patients and to suggest the...
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