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Transient forebrain ischemia induces impairment in cognitive performance prior to extensive neuronal cell death in Mongolian gerbil (Meriones unguiculatus)

Kondo T, Yoshida S, Nagai H, Takeshita , Mino M, Morioka H, Nakajima T, Kusakabe K, Okada T

In Mongolian gerbils, bilateral common carotid artery occlusion (BCCAO) for several minutes induces ischemia, due to an incomplete circle of Willis, resulting in delayed neuronal cell death in the Cornet...
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The neuroprotective mechanism of ampicillin in a mouse model of transient forebrain ischemia

Lee KE, Cho KO, Choi YS, Kim SY

Ampicillin, a beta-lactam antibiotic, dose-dependently protects neurons against ischemic brain injury. The present study was performed to investigate the neuroprotective mechanism of ampicillin in a mouse model of transient global...
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Effects of alpha-Lipoic Acid on Apoptotic Cell Death in Rat Hippocampus Following Transient Forebrain Ischemia-reperfusion Injury

Ahn HC, Song JH, Kim KS, Yoo SJ

  • KMID: 2331506
  • J Korean Soc Emerg Med.
  • 2007 Apr;18(2):134-142.
PURPOSE: The purpose of this study was to evaluate effect of alpha-lipoic acid on apoptotic cell death in rat hippocampal neuron following transient forebrain ischemia-reperfusion (I/R) injury. METHODS: The four-vessel occlusion...
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The Effects of Propofol and Sevoflurane on Neuronal Apoptosis and Bcl-2 Family Protein Expression after Transient Forebrain Ischemia in the Rat

Ahn BG, Kim WS, Kwon JY

BACKGROUND: Anesthetic preconditioning and anesthetics itself have been known to prevent ischemic injury in brain and heart. The purpose of this study was to evaluate the effects of anesthetics and...
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A Simple Method for Predicting Hippocampal Neurodegeneration in a Mouse Model of Transient Global Forebrain Ischemia

Cho KO, Kim SK, Cho YJ, Sung KW, Kim SY

  • KMID: 1587393
  • Korean J Physiol Pharmacol.
  • 2006 Aug;10(4):167-172.
In the present study, we developed a simple method to predict the neuronal cell death in the mouse hippocampus and striatum following transient global forebrain ischemia by evaluating both cerebral...
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Immunohistochemical Study on the Distribution of Tumor Endothelial Marker 7 in the Rat Forebrain

Kang DS, Lee HK, Park HK, Seo IA, Lee KY, Park HT

  • KMID: 2092840
  • Korean J Anat.
  • 2004 Oct;37(5):441-448.
Tumor endothelial marker 7 (TEM7) is a putative transmembrane protein that is highly expressed in the tumor endothelium. In the present study, the expression profile of TEM7 in the rat...
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Reduction of Brain Infarct Size and Extracellular Glutamate Accumulation by Dihydrokinate in Spontaneously Hypertensive Rat after Transient Forebrain Ischemia

Zhang YH, Cai ZH, Chen Y, Li YC

  • KMID: 1588443
  • J Korean Neurosurg Soc.
  • 2004 Oct;36(4):310-316.
No abstract available.
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Postischemic Treatment with Aminoguanidine Inhibits Peroxynitrite Production in the Rat Hippocampus Following Transient Forebrain Ischemia

Choi YS, Yoon YH, Lee JE, Cho KO, Kim SY, Lee SB

  • KMID: 1517030
  • Korean J Physiol Pharmacol.
  • 2004 Feb;8(1):1-5.
Transient forebrain ischemia results in the delayed neuronal death in the CA1 area of the hippocampus. The present study was performed to determine effects of aminoguanidine, a selective iNOS inhibitor,...
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Immunocytochemical Localization of Transforming Growth Factor-alpha in the Forebrain of the Rat

Chung YY, Park SS, Yoon SP, Kim JJ, Moon JS, Jeong SB, Kim HS

  • KMID: 1558768
  • Korean J Anat.
  • 2001 Dec;34(6):589-602.
The distribution of Transforming growth factor-alpha (TGF-alpha) was examined in the rat forebrain by immunocytochemistry. TGF-alpha immunoreactivity was observed in the cerebral hemispheres, thalamus and hypothalamus. Neurons in the olfactory...
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Immunohistochemical Localization of Phospholipase D1 in Developing Rat Forebrain

Choi JS, Min DS, Chung JW, Chun MH, Lee MY

  • KMID: 1559034
  • Korean J Anat.
  • 2001 Aug;34(4):427-434.
Phospholipase D (PLD), one of the intracellular signal transduction enzymes, may play an important role in developing brain. However, the developmental regulation of PLD protein has not been determined. In...
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Increase of peroxynitrite production in the rat brain following transient forebrain ischemia

Kim HJ, Kim SY

  • KMID: 1606934
  • Korean J Physiol Pharmacol.
  • 2001 Jun;5(3):205-212.
It has been proposed that nitric oxide is involved in the pathogenesis of cerebral ischemia-reperfusion. Because superoxide production is also enhanced during reperfusion, the cytotoxic oxidant peroxynitrite could be formed, but it is...
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Inhibition of Apoptosis Following Transient Forebrain Ischemia in Gerbils by Intraischemic Mild Hypothermia

Choi SP, Park KN, You JY, Park SH, Oh DR, Lee WJ, Chun YH, Kim SK

  • KMID: 2194314
  • J Korean Soc Emerg Med.
  • 2001 Mar;12(1):12-20.
BACKGROUND: A brief episode of global forebrain ischemia produces selective and often extensive neuronal loss in several vulnerable brain structures. This cell death does not occur immediately, but is delayed...
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Neuroprotective Effects of Propofol, Ketamine and Propofol-ketamine after Transient Forebrain Ischemia in the Rat

Kwon JY, Jeon JH, Chung KS, Kim IS, Baik SW, Kim HK

BACKGROUND: Intravenous anesthetics such as propofol and ketamine have been known to have neuroprotective effects. However, the combination of these drug is not known. This study was conducted to...
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Expression of c-fos, p53, Transforming Growth Factor-beta1 and Glial Fibrillary Acidic Protein in Hippocampus Following Transient Forebrain Ischemia in Mongolian Gerbil

Lee JH, Hur B

  • KMID: 2141028
  • Korean J Pathol.
  • 2001 Feb;35(1):60-70.
BACKGROUND: Recent studies have shown that delayed neuronal death is closely associated with early gene (c-fos or c-jun)-related apoptosis in addition to hypoxia-induced energy deficiency in the hippocampus. METHODS: To...
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Effect of sedative dose of propofol on neuronal damage after transient forebrain ischemia in Mongolian gerbils

Lee SR

  • KMID: 1580644
  • Korean J Physiol Pharmacol.
  • 2000 Feb;4(1):73-79.
This study investigated whether propofol, an intravenous, non-barbiturate anesthetic, could reduce brain damage following global forebrain ischemia. Transient global ischemia was induced in gerbils by occlusion of bilateral carotid arteries for 3 min....
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Expression of Bcl-2 Protein in the Gerbil Hippocampus Following Transient Forebrain Ischemia and Its Modification by Ischemic Preconditioning

Kim YJ

No abstract available in English.
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The Effects of Forebrain Ischemia on Lidocaine-Induced Seizure Threshold in the Rat

Kim DC, Song HS

BACKGROUND: Seizures are common following many cerebral insults, include global and focal ischemia. However, while the mechanism must relate to some change in the relative activities of excitatory and inhibitory...
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The Relationship between Cerebral Reperfusion Flow and the Ischemic Histopathologic Damage after Incomplete Forebrain Ischemia in Rat Model

Hwang TS, Seo JP, Song KJ, Jeong YK, Shin BH, Kim SH

  • KMID: 2194555
  • J Korean Soc Emerg Med.
  • 1999 Jun;10(2):175-182.
BACKGROUND: Experimental data indicate that low-flow reperfusion following prolonged cardiocirculatory arrest may aggravate early cerebral microcirculatory repefusion disorders. We investigated the influence of cerebral repefusion flow change to the ischemic...
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Effect of Thiamine Deficiency on the Glial Fibrillary Acidic Protein ( GFAP ) Immunoreacitivity of the Astrogial Cells in Rat Forebrain

Kim SH, Kim HT, Kim JH, Kim MH, Hwang SJ, Baik TK

  • KMID: 2342765
  • J Korean Neurol Assoc.
  • 1999 Jan;17(1):152-158.
BACKGROUND: Diverse injury to central nervous system results in proliferation and hypertrophy of astrocytes. The hallmark of this response is enhanced expression of the major intermediate filament protein of astrocyte,...
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beta-Amyloid Neurotoxicity on Basal Forebrain Cholinergic Neuron Cultures

Kim DH, Lee JH, Hong HN, Ko JY

  • KMID: 1529459
  • Korean J Anat.
  • 1997 Jun;30(3):225-234.
beta-amyloid[Abeta] peptide consisting of 40 of 42 amino acids peptide is the principal constituent of senile plaques in Alzheimer`s disease. Recently, it has been demonstrated that this peptide and its...
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