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Comparison of young male mice of two different strains (C57BL/6J and the hybrid B6129SF1/J) in selected behavior tests: a small scale study

Aasland Hansen K, Hudecová A, Haugen F, Skjerve E, Ropstad E, Zimmer K

Background: All mouse strains are different, before choosing a strain for a large study, a small scale study should be done. In this study, we compared young males of two...
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Influences of Dopamine D2, D3 Agonist Quinpirole Dosage on Locomotor Activity Measured by Open-Field Test

Park J, Moon E, Lim HJ, Kim K, Lee JH, Hong YR

Background: Dopamine D2 and D3 receptor agonist quinpirole have been tried as one of drug-induced bipolar animal models. An open-field test is used to assess locomotor activity related to anxiety....
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Ketamine-Induced Behavioral Effects Across Different Sub-AnestheticDose Ranges in Adolescent and Adult Mice

Choi HJ, Im SJ, Park HR, Lee SM, Kim CE, Ryu S

ObjectivesZZKetamine has been reported to have antidepressant effects or psychotomimetic effects. The aim of this study was to investigate the behavioral effects of ketamine treatment at various sub-anesthetic doses in adolescent...
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Protein Kinase C Activity and Delayed Recovery of Sleep-Wake Cycle in Mouse Model of Bipolar Disorder

Moon E, Choe BM, Park JM, Chung YI, Lee BD, Park JH, Lee YM, Jeong HJ, Cheon Y, Choi Y, Park J

OBJECTIVE: Previous studies reported the delayed recovery group after circadian rhythm disruption in mice showed higher quinpiroleinduced locomotor activity. This study aimed to compare not only Protein Kinase C (PKC)...
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Reliability and validity of free software for the analysis of locomotor activity in mice

Hong YR, Moon E

BACKGROUND: Kinovea software that tracking semi-automatically the motion in video screen has been used to study motion-related tasks in several studies. However, the validation of this software in open field...
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Delay in Normalization of Disrupted Sleep-Wake Cycle in Mice as a Bipolar Disorder-Prone Animal Model (Bipolar Disorder-Prone Animal Model)

Kim SY, Moon E, Jeong HJ, Lee YM, Lee BD, Park JM

OBJECTIVES: This study was designed to test the hypothesis that delayed recovery from disrupted circadian rhythm is associated with both manic and depressive episodes in bipolar disorder. METHODS: Twenty-two male mice...
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Delay in the Recovery of Normal Sleep-Wake Cycle after Disruption of the Light-Dark Cycle in Mice: A Bipolar Disorder-Prone Animal Model?

Jung SH, Park JM, Moon E, Chung YI, Lee BD, Lee YM, Kim JH, Kim SY, Jeong HJ

OBJECTIVE: Disruption of the circadian rhythm is known as a provoking factor for manic episodes. Individual differences exist in the recovery rate from disruption in the general population. To develop...
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Chronic Administration of Bacopa Monniera Increases BDNF Protein and mRNA Expressions: A Study in Chronic Unpredictable Stress Induced Animal Model of Depression

Banerjee R, Hazra S, Ghosh AK, Mondal AC

  • KMID: 2316351
  • Psychiatry Investig.
  • 2014 Jul;11(3):297-306.
OBJECTIVE: The present study aimed to investigate whether graded doses of Bacopa Monniera (BM) extract could produce antidepressant-like effects in chronic unpredictable stress (CUS) induced depression in rats and its...
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Chronic Non-Social Stress Affects Depressive Behaviors But Not Anxiety in Mice

Yoon SH, Kim BH, Ye SK, Kim MH

The etiology of most psychiatric disorders is still incompletely understood. However, growing evidence suggests that stress is a potent environmental risk factor for depression and anxiety. In rodents, various stress...
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Chronic Administration of Monosodium Glutamate under Chronic Variable Stress Impaired Hypothalamic-Pituitary-Adrenal Axis Function in Rats

Seo HJ, Ham HD, Jin HY, Lee WH, Hwang HS, Park SA, Kim YS, Choi SC, Lee S, Oh KJ, Kim BS, Park BR, Lee MY

The hypothalamic-pituitary-adrenal (HPA) axis is the primary endocrine system to respond to stress. The HPA axis may be affected by increased level of corticotrophin-releasing factors under chronic stress and by...
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Social Isolation Selectively Increases Anxiety in Mice without Affecting Depression-like Behavior

Kwak C, Lee SH, Kaang BK

It is hypothesized that a number of environmental factors affect animals' behavior. Without controlling these variables, it is very hard for researchers to get not only reliable, but replicable data...
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Behamioral Change and Memory Inpairment Following Transient Forebrain Ischemia in Rats

Rho CK, Kwon JY, Kim HK, Baik SW, Kim IS, Chung KS

This study examined the behavioral change and memory impairment following transient forebrain ischemia in 20 male rats: ten rats were subjected to sham operation. Inchemia was induced by a combination...
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