- Spatiotemporal expression of RCAN1 and its isoform RCAN1-4 in the mouse hippocampus after pilocarpine-induced status epilepticus
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Cho KO, Jeong KH, Cha JH, Kim SY
- KMID: 2466572
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):81-88.
- doi: 10.4196/kjpp.2020.24.1.81
Regulator of calcineurin 1 (RCAN1) can be induced by an intracellular calcium increase and oxidative stress, which are characteristic features of temporal lobe epilepsy. Thus, we investigated the spatiotemporal expression... -
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- Inhibitory effect of carvacrol on lipopolysaccharide-induced memory impairment in rats
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Lee B, Yeom M, Shim I, Lee H, Hahm DH
- KMID: 2466567
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):27-37.
- doi: 10.4196/kjpp.2020.24.1.27
Neuroinflammation is an important process underlying a wide variety of neurodegenerative diseases. Carvacrol (CAR) is a phenolic monoterpene commonly used as a food additive due to its antibacterial properties, but... -
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- Application of Thallium Autometallography for Observation of Changes in Excitability of Rodent Brain following Acute Carbon Monoxide Intoxication
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Lee MS, Yang SB, Heo JH
- KMID: 2470189
- J Korean Soc Clin Toxicol.
- 2019 Dec;17(2):66-78.
- doi: 10.22537/jksct.2019.17.2.66
PURPOSE: Thallium (TI+) autometallography is often used for the imaging of neuronal metabolic activity in the rodent brain under various pathophysiologic conditions. The purpose of this study was to apply... -
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- Heat shock protein 70 increases cell proliferation, neuroblast differentiation, and the phosphorylation of CREB in the hippocampus
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Kwon HJ, Kim W, Jung HY, Kang MS, Kim JW, Hahn KR, Yoo DY, Yoon YS, Hwang IK, Kim DW
- KMID: 2470012
- Lab Anim Res.
- 2019 Dec;35(4):154-164.
- doi: 10.1186/s42826-019-0020-2
In the present study, we investigated the effects of heat shock protein 70 (HSP70) on novel object recognition, cell proliferation, and neuroblast differentiation in the hippocampus. To facilitate penetration into... -
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- The Molecular Signatures of Acute-immobilization-induced Antinociception and Chronic-immobilization-induced Antinociceptive Tolerance
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Feng JH, Lee HJ, Suh HW
- KMID: 2468884
- Exp Neurobiol.
- 2019 Dec;28(6):670-678.
- doi: 10.5607/en.2019.28.6.670
In the present study, the productions of antinociception induced by acute and chronic immobilization stress were compared in several animal pain models. In the acute immobilization stress model (up to... -
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- Neuregulin 1/ErbB4 signaling attenuates neuronal cell damage under oxygen-glucose deprivation in primary hippocampal neurons
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Yoo JY, Kim HB, Yoo SY, Yoo HI, Song DY, Baik TK, Lee JH, Woo RS
- KMID: 2466700
- Anat Cell Biol.
- 2019 Dec;52(4):462-468.
- doi: 10.5115/acb.19.210
The hippocampus is one of the most important brain areas of cognition. This region is particularly sensitive to hypoxia and ischemia. Neuregulin-1 (NRG1) has been shown to be able to... -
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- Benefits of hesperidin in central nervous system disorders: a review
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Kim J, Wie MB, Ahn M, Tanaka A, Matsuda H, Shin T
- KMID: 2466688
- Anat Cell Biol.
- 2019 Dec;52(4):369-377.
- doi: 10.5115/acb.19.119
Citrus species contain significant amounts of flavonoids that possess antioxidant activities; furthermore, dietary citrus is not associated with adverse effects or cytotoxicity in healthy individuals. Hesperidin, which is an abundant... -
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- Berberine Ameliorates Brain Inflammation in Poloxamer 407-Induced Hyperlipidemic Rats
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Kim M, Kim TW, Kim CJ, Shin MS, Hong M, Park HS, Park SS
- KMID: 2467318
- Int Neurourol J.
- 2019 Nov;23(Suppl 2):S102-S110.
- doi: 10.5213/inj.1938216.108
PURPOSE: Hyperlipidemia, which promotes the development of atherosclerosis, ischemic stroke, and other forms of brain injury, can be induced by poloxamer-407. Berberine is a primary pharmacological active component of Coptidis... -
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- Influence of clozapine on neurodevelopmental protein expression and behavioral patterns in animal model of psychiatric disorder induced by low-level of lead
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Lee H, Lee M, Kim HK, Kim YO, Kwon JT, Kim HJ
- KMID: 2461039
- Korean J Physiol Pharmacol.
- 2019 Nov;23(6):467-474.
- doi: 10.4196/kjpp.2019.23.6.467
Exposure to lead during pregnancy is a risk factor for the development of psychiatric disorders in the offspring. In this study, we investigated whether exposure to low levels of lead... -
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- Age-dependent changes of p53 and p63 immunoreactivities in the mouse hippocampus
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Lee TK, Park YE, Park CW, Kim B, Lee JC, Park JH, Lee HA, Won MH, Ahn JH
- KMID: 2470010
- Lab Anim Res.
- 2019 Oct;35(3):140-147.
- doi: 10.1186/s42826-019-0022-0
P53 and its family member p63 play important roles in cellular senescence and organismal aging. In this study, p53 and p63 immunoreactivity were examined in the hippocampus of young, adult... -
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- Promising Neuroimaging Biomarkers in Depression
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Lai CH
- KMID: 2459686
- Psychiatry Investig.
- 2019 Sep;16(9):662-670.
- doi: 10.30773/pi.2019.07.25.2
The neuroimaging has been applied in the study of pathophysiology in major depressive disorder (MDD). In this review article, several kinds of methodologies of neuroimaging would be discussed to summarize... -
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- RbAp48 expression and neuronal damage in the gerbil hippocampus following 5 min of transient ischemia
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Park JH, Lee TK, Kim DW, Park CW, Park YE, Kim B, Lee JC, Lee HA, Won MH, Ahn JH
- KMID: 2470111
- Lab Anim Res.
- 2019 Aug;35(2):78-85.
- doi: 10.1186/s42826-019-0011-3
Histone-binding protein RbAp48 has been known to be involved in histone acetylation, and epigenetic alterations of histone modifications are closely associated with the pathogenesis of ischemic reperfusion injury. In the... -
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- Downregulation of SIRT2 by Chronic Stress Reduces Expression of Synaptic Plasticity-related Genes through the Upregulation of Ehmt2
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Wang SE, Ko SY, Jo S, Jo HR, Han J, Kim YS, Son H
- KMID: 2458551
- Exp Neurobiol.
- 2019 Aug;28(4):537-546.
- doi: 10.5607/en.2019.28.4.537
Silent information regulator 2 (Sirtuin2 / SIRT2) is a NADâº-dependent deacetylase that regulates the cellular oxidative stress response. It modulates transcriptional silencing and protein stability through deacetylation of target proteins... -
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- Long-term Effects of Aripiprazole Treatment during Adolescence on Cognitive Function and Dopamine D2 Receptor Expression in Neurodevelopmentally Normal Rats
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Choi HJ, Im SJ, Park HR, Park S, Kim CE, Ryu S
- KMID: 2457403
- Clin Psychopharmacol Neurosci.
- 2019 Aug;17(3):400-408.
- doi: 10.9758/cpn.2019.17.3.400
OBJECTIVE: This study aimed to investigate the long-term effects of aripiprazole treatment during adolescence on behavior, cognitive function, and dopamine D2 receptor (D2R) expression in adult rats. METHODS: Adolescent male Sprague-Dawley... -
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- Differential Effects of Pentoxifylline on Learning and Memory Impairment Induced by Hypoxic-ischemic Brain Injury in Rats
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Halis H, Bitiktaş , Baştuğ O, Tan B, Kavraal S, Güneş T, Süer C
- KMID: 2457402
- Clin Psychopharmacol Neurosci.
- 2019 Aug;17(3):388-399.
- doi: 10.9758/cpn.2019.17.3.388
OBJECTIVE: Hypoxic-ischemic (HI) brain injury in the human perinatal period often leads to significant long-term neurobehavioral dysfunction in the cognitive and sensory-motor domains. Using a neonatal HI injury model (unilateral... -
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- Transient global amnesia associated with multiple lesions in the corpus callosum and hippocampus
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Kim JA, Min YG, Koo DL
- KMID: 2454732
- Ann Clin Neurophysiol.
- 2019 Jul;21(2):102-104.
- doi: 10.14253/acn.2019.21.2.102
Transient global amnesia is a syndrome of temporary loss of short-term memory and is not accompanied by any other neurological deficit. Diffusion-weighted imaging is useful to improve the diagnostic accuracy... -
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- Dummy Run of Quality Assurance Program before Prospective Study of Hippocampus-Sparing Whole-Brain Radiotherapy and Simultaneous Integrated Boost for Multiple Brain Metastases from Non-small Cell Lung Cancer: Korean Radiation Oncology Group (KROG) 17-06 Study
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Chung E, Noh JM, Lee KC, Kim JH, Chung WK, Suh YG, Lee JA, Seol KH, Wu HG, Kim YS, Noh OK, Park JW, Lee DS, Lee J, Kim YS, Park WY, Kang MK, Jo S, Ahn YC
- KMID: 2454292
- Cancer Res Treat.
- 2019 Jul;51(3):1001-1010.
- doi: 10.4143/crt.2018.415
PURPOSE: Lung Cancer Subcommittee of Korean Radiation Oncology Group (KROG) has recently launched a prospective clinical trial (KROG 17-06) of hippocampus-sparing whole brain radiotherapy (HS-WBRT) with simultaneous integrated boost (SIB)... -
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- Impaired Smooth Pursuit During Transient Global Amnesia
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Kim SH, Park YH, Kim S, Kim JS
- KMID: 2451112
- J Clin Neurol.
- 2019 Jul;15(3):301-307.
- doi: 10.3988/jcn.2019.15.3.301
BACKGROUND AND PURPOSE: During transient global amnesia (TGA), selective impairment of episodic memory is assumed to occur due to alteration in the neuronal network between the hippocampus and parietooccipital cortices... -
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- Increased expression of vascular endothelial growth factor-C and vascular endothelial growth factor receptor-3 after pilocarpine-induced status epilepticus in mice
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Cho KO, Kim JY, Jeong KH, Lee MY, Kim SY
- KMID: 2450495
- Korean J Physiol Pharmacol.
- 2019 Jul;23(4):281-289.
- doi: 10.4196/kjpp.2019.23.4.281
Vascular endothelial growth factor (VEGF)-C and its receptor, vascular endothelial growth factor receptor (VEGFR)-3, are responsible for lymphangiogenesis in both embryos and adults. In epilepsy, the expression of VEGF-C and... -
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- Mechanism of Mindfulness-Based Intervention and Neurobiological Basis
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Kim HG
- KMID: 2454239
- J Korean Soc Biol Ther Psychiatry.
- 2019 Jun;25(2):85-94.
- doi: 10.0000/jksbtp.2019.25.2.85
Mindfulness is a process in which all thoughts, feelings, sensations, and all phenomena that happen to me are uncritically recognized as they are, so that they are eventually accepted and... -
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