Korean J Med.  2003 Oct;65(4):451-457.

Obesity and insulin resistance in apparently healthy Korean men

• Park SH
• Lee WY
• Lee YS
• Rhee EJ
• Kim SW

Abstract

BACKGROUND: Several reports document Asians have a strong tendency of developing insulin resistance. We aimed to evaluate the relative effects of insulin resistance and obesity on coronary heart disease (CHD) risk factors and to clarify whether insulin resistance accentuates the effect of obesity on CHD risk factors in apparently healthy men.
METHODS
We conducted the cross-sectional survey of 4,067 apparently healthy Korean men aged 20-83 years, with a body mass index (BMI) ranging from 15.19 to 40.29 kgm-2. Insulin resistance was defined as the highest decile of homeostasis model assessment (HOMA-IR) in the lean group (BMI<23 kgm-2; 1,438 subjects).
RESULTS
The prevalence of insulin resistance was 24.7% in the overweight subgroup (23CONCLUSION
WC is closely associated with non-traditional markers for CHD, such as raised Apo B, hypertriglyceridaemia, and TC/HDL ratio predicting small, dense LDL particles. Insulin resistance in the obese men is more prevalent than would be expected and accentuates the effect of obesity on CHD risk factors.

Keyword

Obesity; Insulin resistance; Coronary heart disease

MeSH Terms

Apolipoprotein A-I
Apolipoproteins
Apolipoproteins B
Asian Continental Ancestry Group
Blood Glucose
Blood Pressure
Body Mass Index
C-Reactive Protein
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Coronary Disease
Cross-Sectional Studies
Fasting
Homeostasis
Humans
Insulin Resistance*
Insulin*
Male
Multiple Endocrine Neoplasia Type 1
Obesity*
Overweight
Prevalence
Risk Factors
Triglycerides
Waist Circumference
Apolipoprotein A-I
Apolipoproteins
Apolipoproteins B
Blood Glucose
C-Reactive Protein
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Insulin