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HDL Subclass Analysis in Predicting Metabolic Syndrome in Koreans With High HDL Cholesterol Levels

Yang HS, Hur M, Kim H, Kim SJ, Shin S, Di Somma S, on behalf of the GREAT Network

BACKGROUND: High-density lipoprotein cholesterol (HDL-C) is a complex mixture of subclasses with heterogeneous atheroprotective activities. We analyzed HDL-C subclass in relation to cardiovascular risk and metabolic syndrome (MetS) in a...
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Determinants of Circulating Soluble Leptin Receptor and Free Leptin Index in Indonesian Pre-Pubertal Obese Male Children: A Preliminary Cross-Sectional Study

Hendarto A, Nagrani DG, Meiliana A, Sastroasmoro S, Sjarif DR

PURPOSE: This study aimed to investigate the clinical and metabolic determinants of circulating soluble leptin receptor (CSLR) and free leptin index (FLI) in pre-pubertal obese male children. METHODS: We conducted a...
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A prediction model of Nephrolithiasis Risk: A population-based cohort study in Korea

Mukasa D, Sung J

PURPOSE: Well-validated risk prediction models help to stratify individuals on the basis of their disease risks and to guide health care professionals in decision-making. The incidence of nephrolithiasis has been...
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Novel Associations between Related Proteins and Cellular Effects of High-Density Lipoprotein

Choi S, Park YE, Cheon EJ, Kim KY, Kim M, Ann SJ, Noh HM, Lee J, Lee CJ, Lee ST, Lee C, Lee JE, Lee SH

BACKGROUND AND OBJECTIVES: Recent studies have examined the structure-function relationship of high-density lipoprotein (HDL). This study aimed to identify and rank HDL-associated proteins involved in several biological function of HDL. METHODS:...
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Relation between the Total Diet Quality based on Korean Healthy Eating Index and the Incidence of Metabolic Syndrome Constituents and Metabolic Syndrome among a Prospective Cohort of Korean Adults

Shin S, Lee S

OBJECTIVES: This study examined the association of the total diet quality with the incidence risk of metabolic syndrome constituents and metabolic syndrome among Korean adults. METHODS: Based on a community-based cohort...
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Minimizing the risk of perioperative cardiovascular complications in homozygous familial hypercholesterolemia: a case report

Khan S, Min S, Willard G, Lo I, D'Souza R, Park A

Homozygous familial hypercholesterolemia (HoFH) is a rare inherited disorder that presents as abnormally elevated levels of low-density lipoprotein cholesterol and premature heart disease, requiring frequent intervention through lipid apheresis for...
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Efficacy and Safety of Omega-3 Fatty Acids in Patients Treated with Statins for Residual Hypertriglyceridemia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Jun JE, Jeong IK, Yu JM, Kim SR, Lee IK, Han KA, Choi SH, Kim SK, Park HK, Mok JO, Lee YH, Kwon HS, Kim SH, Kang HC, Lee SA, Lee CB, Choi KM, Her SH, Shin WY, Shin MS, Ahn HS, Kang SH, Cho JM, Jo SH, Cha TJ, Kim SY, Won KH, Kim DB, Lee JH, Lee MK

BACKGROUND: Cardiovascular risk remains increased despite optimal low density lipoprotein cholesterol (LDL-C) level induced by intensive statin therapy. Therefore, recent guidelines recommend non-high density lipoprotein cholesterol (non-HDL-C) as a secondary...
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Efficacy and Safety of Pioglitazone versus Glimepiride after Metformin and Alogliptin Combination Therapy: A Randomized, Open-Label, Multicenter, Parallel-Controlled Study

Kim JM, Kim SS, Kim JH, Kim MK, Kim TN, Lee SH, Lee CW, Park JY, Kim ES, Lee KJ, Choi YS, Kim DK, Kim IJ

BACKGROUND: There is limited information regarding the optimal third-line therapy for managing type 2 diabetes mellitus (T2DM) that is inadequately controlled using dual combination therapy. This study assessed the efficacy...
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Dietary and modifiable factors contributing to hyper-LDL-cholesterolemia prevalence in nationwide time series data and the implications for primary prevention strategies

Baik I

BACKGROUND/OBJECTIVES: A number of studies examined secular trends in blood lipid profiles using time series data of national surveys whereas few studies investigated individual-level factors contributing to such trends. The...
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Development of the anti-cancer food scoring system 2.0: Validation and nutritional analyses of quantitative anti-cancer food scoring model

Hong YJ, Kim J, Lee HY, Rim CH

BACKGROUND/OBJECTIVES: We have previously designed the anti-cancer food scoring model (ACFS) 1.0, an evidence-based quantitative tool analyzing the anti-cancer or carcinogenic potential of diets. Analysis was performed using simple quantitative...
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Associations of Dietary Intake with Cardiovascular Disease, Blood Pressure, and Lipid Profile in the Korean Population: a Systematic Review and Meta-Analysis

Kim J, Hoang T, Bu SY, Kim JM, Choi JH, Park E, Lee SM, Park E, Min JY, Lee IS, Youn SY

OBJECTIVE: Previous studies have separately reported the contributions of dietary factors to the risk of cardiovascular disease (CVD) and its markers, including blood pressure (BP) and lipid profile. This study...
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Association Between Serum Bilirubin and the Progression of Carotid Atherosclerosis in Type 2 Diabetes

Lee I, Lee HH, Cho Y, Choi YJ, Huh BW, Lee BW, Kang ES, Park SW, Cha BS, Lee EJ, Lee YH, Huh KB

OBJECTIVE: This study investigated whether serum bilirubin levels can predict the progression of carotid atherosclerosis in individuals with type 2 diabetes mellitus (T2DM). METHODS: This observational study included 1,381 subjects with...
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Efficacy and Safety of High-Dose Atorvastatin in Moderate-to-High Cardiovascular Risk Postmenopausal Korean Women with Dyslipidemia

Moon J, Yoo S, Koh G, Min KW, Shin HH

OBJECTIVE: Postmenopausal women show a more atherogenic lipid profile and elevated cardiovascular risk compared to premenopausal women. The aim of this study was to investigate the efficacy and safety of...
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Quantifications of Lipid Kinetics In Vivo Using Stable Isotope Tracer Methodology

Kim IY, Park S, Jang J, Wolfe RR

Like other bodily materials, lipids such as plasma triacylglycerol, cholesterols, and free fatty acids are in a dynamic state of constant turnover (i.e., synthesis, breakdown, oxidation, and/or conversion to other...
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Cross-Sectional Association of Metabolic Syndrome and Its Components with Serum Testosterone Levels in a Korean-Screened Population

Kim M, Kyung YS, Ahn TY

PURPOSE: We evaluated the associations of metabolic syndrome (MetS) and its components with testosterone levels in the Korean population. MATERIALS AND METHODS: This cross-sectional study was performed among 6,967 adult (age≥20...
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Effect of dyslipidemia on vascular smooth muscle cell proliferation in a porcine coronary restenosis model

Jeong KJ, Kang P, Lee HY, Son HC, Park SH, Choi WS, Koo BS, Jeon CY, Baek SH, An YJ, Kim HK, Kim SS, Park JK, Bae IH, Park DS, Shim JW, Kim JU, Kim NY, Kim SU, Lim KS, Jeong MH

This study aimed to examine the effect of a mild elevation in serum cholesterol level in a porcine coronary overstretch restenosis model using a balloon angioplasty catheter or drug-eluting coronary...
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Effects of Exercise on the Body Composition and Lipid Profile of Individuals with Obesity: A Systematic Review and Meta-Analysis

Kim KB, Kim K, Kim C, Kang SJ, Kim HJ, Yoon S, Shin YA

BACKGROUND: Numerous researchers have worked to develop treatments for obesity; however, the prevalence of obesity continues to increase in many countries. Moreover, the effects of physical activity and exercise on...
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Association between Abdominal Obesity and Cardiovascular Risk Factors in Adults with Normal Body Mass Index: Based on the Sixth Korea National Health and Nutrition Examination Survey

Kim HY, Kim JK, Shin GG, Han JA, Kim JW

BACKGROUND: Abdominal obesity predisposes individuals to cardiovascular disease, but the data in adults with normal body mass index (BMI) are relatively rare. This study aimed to evaluate the characteristics of...
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Association between High-Density Lipoprotein Cholesterol and Vitamin D Levels in Adult Men in the Fifth Korea National Health and Nutrition Examination Survey

Jung IK

BACKGROUND: Patients with metabolic syndrome had low high-density lipoprotein cholesterol (HDL-C) levels. Moreover, vitamin D deficiency is also related to metabolic syndrome. This study aimed to investigate the association between...
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Lipid accumulation product is a predictor of nonalcoholic fatty liver disease in childhood obesity

Özcabı B, Demirhan S, Akyol M, Öztürkmen Akay H, Güven A

BACKGROUND: Lipid accumulation product (LAP) is associated with the presence and severity of nonalcoholic fatty liver disease (NAFLD) in adults. PURPOSE: Here we evaluated the ability of LAP to predict NAFLD...
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