J Korean Soc Hypertens.  2010 Dec;16(4):44-53.

Telmisartan Versus Carvedilol in Hypertensive Patients with Metabolic Syndrome: Effects on Blood Pressure, Arterial Stiffness, Blood Glucose, and Lipid Metabolism

• Kim YS
• Kim SY
• Bae JH
• Nah DY
• Rhee MY
• Lee MM
• Huh HJ
• Chae SL
• Kim YK

Abstract

BACKGROUND
We compared the effects of telmisartan and carvedilol on blood pressure (BP), aortic stiffness, glucose, and lipid metabolism in hypertensive patients with metabolic syndrome (MS).
METHODS
A total of 26 untreated hypertensive patients with MS was randomly assigned into either telmisartan (N=13) or carvedilol (N=13) group and treated for a 24-week period. Systolic and diastolic BPs were measured every 4 weeks. Fasting plasma glucose (FG), total cholesterol (TC), triglyceride (TG), HDL-cholesterol (HDL), LDL-cholesterol (LDL), adiponectin, brachial-ankle pulse wave velocity (baPWV), and heart-femoral PWV (hfPWV) were measured at baseline and at weeks 12 and 24.
RESULTS
Systolic and diastolic BPs, baPWV, hfPWV were significantly decreased in both groups and there were no significant differences in the changes of BP, baPWV, and hfPWV between the two groups during the treatment period. In telmisartan group, there were no significant changes in levels of FG, TC, TG, HDL, LDL, and adiponectin at week 24. In carvedilol group, there were no significant changes in levels of FG, TC, and LDL at week 24. However, TG level was significantly increased (baseline, 162.9+/-64.6 mg/dL; week 24, 198.0+/-69.8 mg/dL; p=0.046), and levels of HDL (baseline, 48.7+/-8.8 mg/dL; week 24, 42.9+/-7.2 mg/dL; p=0.044) and adiponectin (baseline, 7.0+/-4.1 microg/mL; week 24 5.8+/-3.2 microg/mL; p=0.003) were significantly decreased.
CONCLUSION
Telmisartan and carvedilol are comparable in reducing BP and aortic stiffness. However, compared with telmisartan, carvedilol may adversely affect adiponectin level and lipid metabolism without adverse impact on FG in hypertensive patients with MS.

Keyword

Telmisartan; Carvedilol; Hypertension; Metabolic Syndrome

MeSH Terms

Adiponectin
Arterial Pressure
Benzimidazoles
Benzoates
Blood Glucose
Blood Pressure
Carbazoles
Cholesterol
Fasting
Glucose
Humans
Hypertension
Lipid Metabolism
Plasma
Propanolamines
Pulse Wave Analysis
Vascular Stiffness
Adiponectin
Benzimidazoles
Benzoates
Blood Glucose
Carbazoles
Cholesterol
Glucose
Propanolamines