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Doxazosin Treatment Attenuates Carbon Tetrachloride-Induced Liver Fibrosis in Hamsters through a Decrease in Transforming Growth Factor beta Secretion

Munoz-Ortega MH, Llamas-Ramirez RW, Romero-Delgadillo NI, Elias-Flores TG, de Jesus Tavares-Rodriguez E, del Rosario Campos-Esparza M, Cervantes-Garcia D, Munoz-Fernandez L, Gerardo-Rodriguez M, Ventura-Juarez J

BACKGROUND/AIMS: The development of therapeutic strategies for the treatment of cirrhosis has become an important focus for basic and clinical researchers. Adrenergic receptor antagonists have been evaluated as antifibrotic drugs...
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Adrenocorticotropic Hormone-Independent Cushing Syndrome with Bilateral Cortisol-Secreting Adenomas

Ku EJ, Hong AR, Kim YA, Bae JH, Chang MS, Kim SW

A 48-year-old woman was incidentally found to have bilateral adrenal masses, 2.8 cm in diameter on the right, and 2.3 cm and 1.7 cm in diameter on the left, by...
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Effects of Histamine on Cultured Interstitial Cells of Cajal in Murine Small Intestine

Kim BJ, Kwon YK, Kim E, So I

Interstitial cells of Cajal (ICCs) are the pacemaker cells in the gastrointestinal tract, and histamine is known to regulate neuronal activity, control vascular tone, alter endothelial permeability, and modulate gastric...
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High K(+)-Induced Relaxation by Nitric Oxide in Human Gastric Fundus

Kim DH, Kim YC, Choi W, Yun HY, Sung R, Kim HS, Kim H, Yoo RY, Park SM, Yun SJ, Song YJ, Xu WX, Lee SJ

This study was designed to elucidate high K(+)-induced relaxation in the human gastric fundus. Circular smooth muscle from the human gastric fundus greater curvature showed stretch-dependent high K+ (50 mM)-induced...
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Activation of the cGMP/Protein Kinase G Pathway by Nitric Oxide Can Decrease TRPV1 Activity in Cultured Rat Dorsal Root Ganglion Neurons

Jin Y, Kim J, Kwak J

Recent studies have demonstrated that nitric oxide (NO) activates transient receptor potential vanilloid subtype 1 (TRPV1) via S-nitrosylation of the channel protein. NO also modulates various cellular functions via activation...
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Dendroaspis natriuretic peptide regulates the cardiac L-type Ca2+ channel activity by the phosphorylation of alpha1c proteins

Park SA, Kim TG, Han MK, Ha KC, Kim SZ, Kwak YG

  • KMID: 1383798
  • Exp Mol Med.
  • 2012 Jun;44(6):363-368.
Dendroaspis natriuretic peptide (DNP), a new member of the natriuretic peptide family, is structurally similar to atrial, brain, and C-type natriuretic peptides. However, the effects of DNP on the cardiac...
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The Effect of Enalapril and Carvedilol on Left Ventricular Dysfunction in Middle Childhood and Adolescent Patients With Muscular Dystrophy

Kwon HW, Kwon BS, Kim GB, Chae JH, Park JD, Bae EJ, Noh CI

BACKGROUND AND OBJECTIVES: In Duchenne and Becker muscular dystrophies, cardiac function deteriorates with time resulting in heart failure which is often fatal. We prospectively evaluated the effect of enalapril and...
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Nitric Oxide-mediated Relaxation by High K+ in Human Gastric Longitudinal Smooth Muscle

Kim YC, Choi W, Yun HY, Sung R, Yoo RY, Park SM, Yun SJ, Kim MJ, Song YJ, Xu WX, Lee SJ

This study was designed to elucidate high-K+induced response of circular and longitudinal smooth muscle from human gastric corpus using isometric contraction. Contraction from circular and longitudinal muscle stripes of gastric...
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Hypertensive Heart Failure Associated with Middle Aortic Syndrome Reversed Dramatically by Endovascular Management

Kim W, Park CS, Kim HJ, Kim KH, An HM, Kim YH, Lim CH, Kang WY, Hwang SH, Kim W

A 42-year-old male patient presented with refractory hypertension and congestive heart failure. He had taken hydrochlorthiazide 50 mg, carvedilol 25 mg, diltiazem 180 mg, and losartan 100 mg per day....
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Two-Year Clinical Outcome after Carvedilol-Loaded Stent Implantation in Patients with Coronary Artery Disease

Kim HK, Hong YJ, Jeong MH, Kim W, Kim SS, Ko JS, Lee MG, Sim DS, Park KH, Yoon NS, Yoon HJ, Kim KH, Park HW, Kim JH, Ahn Y, Cho JG, Park JC, Kang JC

BACKGROUND/AIMS: Carvedilol is an antioxidant that inhibits smooth muscle cell proliferation and migration. The aim of this study was to investigate the beneficial effects of carvedilol-loaded stents on 2-year clinical...
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Telmisartan Versus Carvedilol in Hypertensive Patients with Metabolic Syndrome: Effects on Blood Pressure, Arterial Stiffness, Blood Glucose, and Lipid Metabolism

Kim YS, Kim SY, Bae JH, Nah DY, Rhee MY, Lee MM, Huh HJ, Chae SL, Kim YK

  • KMID: 1750379
  • J Korean Soc Hypertens.
  • 2010 Dec;16(4):44-53.
BACKGROUND: We compared the effects of telmisartan and carvedilol on blood pressure (BP), aortic stiffness, glucose, and lipid metabolism in hypertensive patients with metabolic syndrome (MS). METHODS: A total of 26...
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Role of PKG-L-type calcium channels in the antinociceptive effect of intrathecal sildenafil

Kim WM, Yoon MH, Cui JH

Sildenafil increases the cyclic guanosine monophosphate (cGMP) by inhibition of a phosphodiesterase 5, thereby leading to an antinociceptive effect. The increased cGMP may exert the effect on an L-type calcium...
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Frovatriptan is Effective and Well Tolerated in Korean Migraineurs: A Double-Blind, Randomized, Placebo-Controlled Trial

Moon HS, Chu MK, Park JW, Oh K, Chung JM, Cho YJ, Kim EG, Do JK, Jung HG, Kwon SU

BACKGROUND AND PURPOSE: Frovatriptan is a selective 5-HT1B/1D agonist with a long duration of action and a low incidence of side effects. Although several placebo-controlled trials have documented the clinical...
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Comparing the Effects of Carvedilol Enantiomers on Regression of Established Cardiac Hypertrophy Induced by Pressure Overload

Hao J, Kim CH

Pressure overload diseases such as valvular stenosis and systemic hypertension morphologically manifest in patients as cardiac concentric hypertrophy. Preventing cardiac remodeling due to increased pressure overload is important to reduce...
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A Case of Steroid-responsive C1q Nephropathy Presenting as Focal Segmental Glomerulosclerosis

Yune YM, Choi SJ, Kim NR, Park MY, Kwon KW, Jin SY, Kim JK, Hwang SD

  • KMID: 2307177
  • Korean J Nephrol.
  • 2009 Nov;28(6):648-652.
C1q nephropathy is an immune complex glomerulonephritis defined by the presence of mesangial immunoglobins and complement deposits, most notably C1q, and the absence of clinical and laboratory evidence of systemic...
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The Role of Beta Blockers in Treating Hypertensive Patients

Lim SY

Beta-blockers have been used to treat hypertension for many years. Although beta-blockers can lower blood pressure, current data concerning the efficacy of these drugs have been disappointing, and the value...
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Forskolin Enhances Synaptic Transmission in Rat Dorsal Striatum through NMDA Receptors and PKA in Different Phases

Cho HS, Lee HH, Choi SJ, Kim KJ, Jeun SH, Li QZ, Sung KW

The effect of forskolin on corticostriatal synaptic transmission was examined by recording excitatory postsynaptic currents (EPSCs) in rat brain slices using the whole-cell voltage-clamp technique. Forskolin produced a dose-dependent increase...
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Cardioprotective signaling cascade of A2 adenosine receptor agonist 5'-N-ethylcarboxaminidoadenosine against myocardial reperfusion injury

Lee YC, Jang YH, Kim CJ, Kim JM

BACKGROUND: This experiments investigated the signaling cascade responsible for anti-infarct effect by an A2 adenosine receptor (AR) agonist 5'-N-Ethylcarboxaminidoadenosine (NECA). METHODS: Langendorff perfused isolated rat hearts were subjected to 30 minutes...
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Protein kinase C micron plays an essential role in hypertonicity-induced heat shock protein 70 expression

Lim YS, Lee JS, Huang TQ, Seo JS

Heat shock protein 70 (HSP70), which evidences important functions as a molecular chaperone and anti-apoptotic molecule, is substantially induced in cells exposed to a variety of stresses, including hypertonic stress,...
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Matrix Metalloproteinase-2 Expression of the Injured Anterior Cruciate Ligament in the Knee and Changes in Relation to Signal Transduction Pathways

Lee HS, Kwon JY, Woo YK

  • KMID: 2199064
  • J Korean Orthop Res Soc.
  • 2008 Oct;11(2):64-71.
PURPOSE: This study was designed to pursue the basic relationship between MMP-2 and ligament injury via ex vivo stretching of the anterior cruciate ligament (ACL) and its changes by signal...
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