Immune Netw.  2010 Feb;10(1):1-4. 10.4110/in.2010.10.1.1.

Role of IL-23 and Th17 Cells in Airway Inflammation in Asthma

Affiliations
  • 1Department of Molecular Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan. nakajimh@faculty.chiba-u.jp
  • 2Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan.

Abstract

Asthma is characterized by chronic airway inflammation with intense eosinophil and lymphocyte infiltration, mucus hyperproduction, and airway hyperresponsiveness. Accumulating evidence indicates that antigen-specific Th2 cells and their cytokines such as IL-4, IL-5, and IL-13 orchestrate these pathognomonic features of asthma. In addition, we and others have recently shown that IL-17-producing CD4+ T cells (Th17 cells) and IL-23, an IL-12-related cytokine that is essential for survival and functional maturation of Th17 cells, are involved in antigen-induced airway inflammation. In this review, our current understanding of the roles of IL-23 and Th17 cells in the pathogenesis of allergic airway inflammation will be summarized.

Keyword

Asthma; Eosinophils; Neutrophils; IL-17; IL-23; Th17 cells

MeSH Terms

Asthma
Cytokines
Eosinophils
Inflammation
Interleukin-13
Interleukin-17
Interleukin-23
Interleukin-4
Interleukin-5
Lymphocytes
Mucus
Neutrophils
T-Lymphocytes
Th17 Cells
Th2 Cells
Cytokines
Interleukin-13
Interleukin-17
Interleukin-23
Interleukin-4
Interleukin-5
Full Text Links
  • IN
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
    DB Error: unknown error