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Severe asthma exacerbation associated with COVID-19 in children: A case report

Yeh HR, Lim MS, Seo HJ, Lee EJ, Kim JG, Yum HY

Epidemiological evidence suggests that the severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is lesser and morbidity and mortality rates are lower in children than in adults. Although...
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Pattern and risk factor of lower respiratory illness in children who survived meconium aspiration syndrome

Kim KH, Kim D, Youn Y, Lee J, Kim HS

Purpose: Meconium aspiration syndrome (MAS) occurs when aspiration of meconium itself or meconium-stained amniotic fluid enters into the airways. The relationship between MAS and how they affect the respiratory outcome...
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Mesenchymal Stem Cells Attenuate Asthmatic Inflammation and Airway Remodeling by Modulating Macrophages/Monocytes in the IL-13-Overexpressing Mouse Model

Mo Y, Kim Y, Bang JY, Jung J, Lee CG, Elias JA, Kang HR

Mesenchymal stem cells (MSCs) are attractive alternatives to conventional anti-asthmatic drugs for severe asthma. Mechanisms underlying the anti-asthmatic effects of MSCs have not yet been elucidated. This study evaluated the...
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Adverse Effects of Air Pollution on Pulmonary Diseases

Ko UW, Kyung SY

Environmental exposure to air pollution is known to have adverse effects on various organs. Air pollution has greater effects on the pulmonary system as the lungs are directly exposed to...
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Respiratory Reviews in Asthma 2022

Lee JH, Kim Jy, Choi JS, Na JO

Asthma is a chronic inflammatory disease of the airways characterized by varying and recurrent symptoms, reversible airway obstruction, and bronchospasm. In this paper, clinical important studies on asthma published between...
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Principles of the use of inhaler devices in asthma treatment

Kang SY, Min TK

Background: Inhaler therapy is the most critical route of administering drugs in the management of asthma due to its rapid onset of action, better pulmonary efficacy, and reduced risk of...
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Health Effects Associated With Humidifier Disinfectant Use: A Systematic Review for Exploration

Song JH, Ahn J, Park MY, Park J, Lee YM, Myong JP, Koo JW, Lee J

Background: It has been 10 years since the outbreak of lung disease caused by humidifier disinfectants in Korea, but the health effects have not yet been summarized. Therefore, this study...
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Phenotype of Asthma-COPD Overlap in COPD and Severe Asthma Cohorts

Joo H, Park SY, Park SY, Park SY, Kim SH, Cho YS, Yoo KH, Jung KS, Rhee CK

Background: Asthma and chronic obstructive pulmonary disease (COPD) are airway diseases with similar clinical manifestations, despite differences in pathophysiology. AsthmaCOPD overlap (ACO) is a condition characterized by overlapping clinical features...
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Changes in levels of fractional exhaled and nasal nitric oxide after treatment in allergic rhinitis

Hong S, Jo CG, Kim H, Lee YS, Bae WY, Jung JA

Purpose: Recent studies have reported that nasal nitric oxide (NO) increases in patients with allergic rhinitis (AR) and bronchial asthma (BA), and can be used as a noninvasive test to...
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Cigarette smoke extract contributes to the inception and aggravation of asthmatic inflammation by stimulating innate immunity

Kim Y, Kim J, Mo Y, Park DE, Lee HS, Jung JW, Kang HR

Purpose: Smoking is a risk factor for the development of asthma and worsens the long-term prognosis of asthma. This study investigated the effect of cigarette smoke extract (CSE) on innate...
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Association between Serum Folic Acid Levels and Asthma in the Korean Population: A Study Based on the 2016–2018 Korea National Health and Nutrition Examination Survey

Kim SR, Park EJ, Cho YH, Lee SY, Choi JI, Lee YI, Lee SR, Kim YJ, Lee JG, Yi YH, Tak YJ, Lee SH, Kim GL, Ra YJ

Background: Folic acid is involved in inflammatory reactions; however, the association between folic acid and allergic diseases, particularly asthma, remains unclear. Thus, this study aimed to evaluate the association between...
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MicroRNA-21 promotes epithelial-mesenchymal transition and migration of human bronchial epithelial cells by targeting poly (ADP-ribose) polymerase-1 and activating PI3K/AKT signaling

Zhang S, Sun P, Xiao X, Hu Y, Qian Y, Zhang Q

Epithelial-mesenchymal transition (EMT ) is known to be involved in airway remodeling and fibrosis of bronchial asthma. However, the molecular mechanisms leading to EMT have yet to be fully clarified....
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Effects of Asthma Medication Type on Asthma Exacerbation in a Real-World Setting

Choi YJ, Kim CH, Lee J, Byun MK, Cho JH, Park HJ

Purpose: Currently, there are multiple options for the pharmacological treatment of asthma. This study aimed to compare the effects of different asthma medications on exacerbation in a real-world setting. Materials and...
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A Pilot Randomized Trial of As-Needed Budesonide-Formoterol for Stepping Down Controller Treatment in Moderate Asthma with Complete Remission

Nakwan N, Ruklerd T, Taptawee P

Background: The use of low-dose inhaled corticosteroid-formoterol as reliever monotherapy has recently been recommended in the asthma treatment guidelines. However, the efficacy of this treatment strategy has not yet been...
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Understanding the Mouse Model of Respiratory Allergic Diseases

Park SC

Respiratory allergic diseases, represented by allergic rhinitis and asthma, show various features due to their complex pathophysiology. Mouse models of respiratory allergic diseases replicate the characteristics of human allergic rhinitis...
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Measurement and Interpretation of Fractional Exhaled Nitric Oxide

Kwon JW

Nitric oxide is produced by the human lungs and increases in response to type 2 inflammation. The level of fractional exhaled nitric oxide (FeNO) may reflect type 2 inflammation in...
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The Clinical Efficacy of Type 2 Inflammation-Specific Agents Targeting Interleukins in Reducing Exacerbations in Severe Asthma: A Meta-Analysis

Lee J, Song JU, Kim YH

Purpose: Monoclonal antibodies against type 2 inflammatory pathways are currently promising therapeutics for severe asthma.The aim of this study was to determine how well type 2 (T2) inflammation-specific agents targeting...
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Composition of Human Breast Milk Microbiota and Its Role in Children’s Health

Notarbartolo V, Giuffrè M, Montante C, Corsello G, Carta M

Human milk contains a number of nutritional and bioactive molecules including microorganisms that constitute the so-called “Human Milk Microbiota (HMM)”. Recent studies have shown that not only bacterial but also...
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Association between Soft Drink Consumption and Asthma among Korean Adults

Lee S, Kim M

Background: Asthma is a common respiratory disease, and various factors are involved in its development. This study investigated the association between soft drink consumption and asthma among Korean adults. Methods: The...
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Status of Studies Investigating Asthma–Chronic Obstructive Pulmonary Disease Overlap in Korea: A Review

Jo YS

There is a considerable number of individuals who exhibit features of both asthma and chronic obstructive pulmonary disease (COPD), defined as asthma-COPD overlap (ACO). Many studies have reported that these...
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