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An Alternative Dendritic Cell-Induced Murine Model of Asthma Exhibiting a Robust Th2/Th17-Skewed Response

Park SC, Kim H, Bak Y, Shim D, Kwon KW, Kim CH, Yoon JH, Shin SJ

PURPOSE: Simple and reliable animal models of human diseases contribute to the understanding of disease pathogenesis as well as the development of therapeutic interventions. Although several murine models to mimic...
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Oxidative Stress Modulates the Expression Pattern of Peroxiredoxin-6 in Peripheral Blood Mononuclear Cells of Asthmatic Patients and Bronchial Epithelial Cells

Shim HJ, Park SY, Kwon HS, Song WJ, Kim TB, Moon KA, Choi JP, Kim SJ, Cho YS

PURPOSE: Reduction-oxidation reaction homeostasis is vital for regulating inflammatory conditions and its dysregulation may affect the pathogenesis of chronic airway inflammatory diseases such as asthma. Peroxiredoxin-6, an important intracellular anti-oxidant...
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Role of IL-17A in Chronic Rhinosinusitis With Nasal Polyp

Ryu G, Bae JS, Kim JH, Kim EH, Lyu L, Chung YJ, Mo JH

PURPOSE: Th17-associated inflammation is increased in chronic rhinosinusitis with nasal polyp (CRSwNP), and is associated with disease severity and steroid resistance. Overexpressed interleukin (IL)-17A affects CRSwNP by tissue remodeling, eosinophilic...
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Relationship of Microbial Profile With Airway Immune Response in Eosinophilic or Neutrophilic Inflammation of Asthmatics

Son JH, Kim JH, Chang HS, Park JS, Park CS

PURPOSE: Different characteristics of airway microbiome in asthmatics may lead to differential immune responses, which in turn cause eosinophilic or neutrophilic airway inflammation. However, the relationships among these factors have...
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Innate Lymphoid Cells in the Airways: Their Functions and Regulators

Orimo K, Saito H, Matsumoto , Morita H

Since the airways are constantly exposed to various pathogens and foreign antigens, various kinds of cells in the airways—including structural cells and immune cells—interact to form a precise defense system...
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Prevalence and Clinical Characteristics of Asymptomatic Pyuria in Chronic Kidney Disease

Kwon YE, Oh DJ, Kim MJ, Choi HM

BACKGROUND: Pyuria seems to be common in chronic kidney disease (CKD), irrespective of urinary tract infection (UTI). It has been hypothesized that sterile pyuria occurs in CKD because of chronic...
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Combination of Methotrexate and Leflunomide for Adult-onset Still's Disease: A Case Report and Literature Review

Lee EE, Kim MJ, Song YW, Park JK

The treatment of adult-onset Still's disease (AOSD) aims to control systemic inflammation and prevent organ damage. Systemic inflammation can be controlled with corticosteroid (CS) monotherapy in most cases. However, symptoms...
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Current Diagnosis and Management of Hypersensitivity Pneumonitis

Leone PM, Richeldi L

Hypersensitivity Pneumonitis (HP) one of the most common interstitial lung diseases (ILDs) is characterized by exposure to an inhaled inciting antigen that leads to a host immunologic reaction determining interstitial...
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Effect of saccharin on inflammation in 3T3-L1 adipocytes and the related mechanism

Kim HL, Ha AW, Kim WK

BACKGROUND/OBJECTIVES: Excessive intake of simple sugars induces obesity and increases the risk of inflammation. Thus, interest in alternative sweeteners as a sugar substitute is increasing. The purpose of this study...
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A Case of Cutaneous Leukocytoclastic Vasculitis Associated with Granulocyte Colony-Stimulating Factor: An Unusual Presentation

Yoon D, Byun HJ, Oh SJ, Park JH, Lee DY

Drug-induced vasculitis is an inflammation of small-sized blood vessel caused by the use of drugs. It accounts for approximately 10% of acute cutaneous vasculitis. Propylthiouracil, hydralazine, and allopurinol have been...
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Molecular epidemiology and characterization of Streptococcus mutans strains in Korea

Kim SY, Bae IK, Lee JH, Shin JH, Kim JB

OBJECTIVES: We investigated the characteristics of Streptococcus mutans in the national culture collection from Korea. Twenty-nine (dental plaque, n=27; endodontic infections, n=1; blood, n=1) isolates were included in this study. METHODS:...
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Diagnosis and treatment of interstitial lung disease: focusing on idiopathic pulmonary fibrosis

Kang HR, Choi SM

Interstitial lung disease (ILD) is a rare condition characterized by extensive inflammation and fibrosis mainly involving the pulmonary interstitium or alveoli. Usually, patients with ILD clinically present with chronic cough...
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The Amniotic Fluid Proteome Differs Significantly between Donor and Recipient Fetuses in Pregnancies Complicated by Twin-to-Twin Transfusion Syndrome

Kim SM, Cho BK, Kim BJ, Lee HY, Norwitz ER, Kang MJ, Lee SM, Park CW, Jun JK, Yi EC, Park JS

BACKGROUND: Twin-to-twin transfusion syndrome (TTTS) is a serious complication of monochorionic twin pregnancies. It results from disproportionate blood supply to each fetus caused by abnormal vascular anastomosis within the placenta....
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Associations of Plasma Neutrophil Gelatinase-associated Lipocalin, Anemia, and Renal Scarring in Children with Febrile Urinary Tract Infections

Lee JH, Yim HE, Yoo KH

BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL), a bacteriostatic agent, is known to inhibit erythropoiesis leading to anemia. We aimed to investigate the associations of NGAL, anemia, and renal scarring in children...
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Can Calprotectin Show Subclinical Inflammation in Familial Mediterranean Fever Patients?

Asan G, Derin ME, DoÄŸan HO, Bayram M, Åžahin M, Åžahin A

BACKGROUND: Familial Mediterranean fever (FMF) is an autoinflammatory disease that has self-limiting inflammatory attacks during polyserositis. Hepcidin is a protein, and interleukin-6 stimulation increases hepcidin levels. Calprotectin (CLP) is a...
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Thelazia Callipaeda Infestation with Tarsal Ectropion

Lee YJ, Kim SE, Kim JH, Paik JS, Yang SW

PURPOSE: To report a case of Thelazia callipaeda infestation with tarsal ectropion. CASE SUMMARY: A 79-year-old man presented with epiphora and a sensation of a foreign body in his right eye...
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Comparison of Clinical Characteristics between Patients with Cytomegalovirus Positive and Negative Hypertensive Uveitis

Kim JH, Lee JY, Choi JA

PURPOSE: To compare the clinical characteristics of hypertensive uveitis patients, with and without cytomegalovirus (CMV) infection. METHODS: CMV polymerase chain reaction (PCR) was performed on the aqueous humor of 61 patients...
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Multifaceted Actions of Succinate as a Signaling Transmitter Vary with Its Cellular Locations

Guo Y, Cho SW, Saxena D, Li X

Since the identification of succinate's receptor in 2004, studies supporting the involvement of succinate signaling through its receptor in various diseases have accumulated and most of these investigations have highlighted...
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Successful Treatment of a Korean Infant with Giant Cell Hepatitis with Autoimmune Hemolytic Anemia Using Rituximab

Kim YH, Kim JW, Lee EJ, Kang GH, Kang HJ, Moon JS, Ko JS

Giant cell hepatitis with autoimmune hemolytic anemia (AHA) is a rare disease of infancy characterized by the presence of both Coombs-positive hemolytic anemia and progressive liver disease with giant cell...
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Hyperuricemia Is Not Predictive of Long-Term Outcome in Patients with Stable Chronic Obstructive Pulmonary Disease

Hwang JJ, Oh YM, Rhee CK, Yoo KH, Park YB, Yoon HI, Lim SY, Lee JH, Kim EK, Kim TH, Lee SW, Lee SD, Lee JS, KOLD Group

BACKGROUND: Although the association of hyperuricemia with an increased risk of mortality has been demonstrated in the context of acute exacerbation of chronic obstructive pulmonary disease (COPD), the long-term outcomes...
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