- An Alternative Dendritic Cell-Induced Murine Model of Asthma Exhibiting a Robust Th2/Th17-Skewed Response
-
Park SC, Kim H, Bak Y, Shim D, Kwon KW, Kim CH, Yoon JH, Shin SJ
- KMID: 2471235
- Allergy Asthma Immunol Res.
- 2020 May;12(3):537-555.
- doi: 10.4168/aair.2020.12.3.537
PURPOSE: Simple and reliable animal models of human diseases contribute to the understanding of disease pathogenesis as well as the development of therapeutic interventions. Although several murine models to mimic... -
- CITED
-
- Close
- SHARE
-
- Close
- Role of IL-17A in Chronic Rhinosinusitis With Nasal Polyp
-
Ryu G, Bae JS, Kim JH, Kim EH, Lyu L, Chung YJ, Mo JH
- KMID: 2471233
- Allergy Asthma Immunol Res.
- 2020 May;12(3):507-522.
- doi: 10.4168/aair.2020.12.3.507
PURPOSE: Th17-associated inflammation is increased in chronic rhinosinusitis with nasal polyp (CRSwNP), and is associated with disease severity and steroid resistance. Overexpressed interleukin (IL)-17A affects CRSwNP by tissue remodeling, eosinophilic... -
- CITED
-
- Close
- SHARE
-
- Close
- Relationship of Microbial Profile With Airway Immune Response in Eosinophilic or Neutrophilic Inflammation of Asthmatics
-
Son JH, Kim JH, Chang HS, Park JS, Park CS
- KMID: 2471226
- Allergy Asthma Immunol Res.
- 2020 May;12(3):412-429.
- doi: 10.4168/aair.2020.12.3.412
PURPOSE: Different characteristics of airway microbiome in asthmatics may lead to differential immune responses, which in turn cause eosinophilic or neutrophilic airway inflammation. However, the relationships among these factors have... -
- CITED
-
- Close
- SHARE
-
- Close
- Innate Lymphoid Cells in the Airways: Their Functions and Regulators
-
Orimo K, Saito H, Matsumoto , Morita H
- KMID: 2471224
- Allergy Asthma Immunol Res.
- 2020 May;12(3):381-398.
- doi: 10.4168/aair.2020.12.3.381
Since the airways are constantly exposed to various pathogens and foreign antigens, various kinds of cells in the airways—including structural cells and immune cells—interact to form a precise defense system... -
- CITED
-
- Close
- SHARE
-
- Close
- Effect of saccharin on inflammation in 3T3-L1 adipocytes and the related mechanism
-
Kim HL, Ha AW, Kim WK
- KMID: 2471878
- Nutr Res Pract.
- 2020 Apr;14(2):109-116.
- doi: 10.4162/nrp.2020.14.2.109
BACKGROUND/OBJECTIVES: Excessive intake of simple sugars induces obesity and increases the risk of inflammation. Thus, interest in alternative sweeteners as a sugar substitute is increasing. The purpose of this study... -
- CITED
-
- Close
- SHARE
-
- Close
- Lovastatin derivative dehydrolovastatin ameliorates ulcerative colitis in mice by suppressing NF-κB and inflammatory cytokine expression
-
Zhang X, Deng QH, Deng JH, Wang SJ, Chen Q
- KMID: 2471035
- Korean J Physiol Pharmacol.
- 2020 Mar;24(2):137-147.
- doi: 10.4196/kjpp.2020.24.2.137
Ulcerative colitis (UC) is associated with intestinal immune imbalance and inflammatory response. Because dehydrolovastatin (DLVT), a derivative of lovastatin, has been recently shown to inhibit inflammation and relieve immune arthritis... -
- CITED
-
- Close
- SHARE
-
- Close
- Primary Nasal Epithelial Cells From Allergic and Non-allergic Individuals Show Comparable Barrier Function
-
Waltl EE, Stanek V, Mueller CA, Kiss R, Eckl-Dorna J, Valenta R, Niederberger V
- KMID: 2468468
- Allergy Asthma Immunol Res.
- 2020 Mar;12(2):364-370.
- doi: 10.4168/aair.2020.12.2.364
Previous reports suggested that ex vivo cultured primary nasal epithelial cells from allergic patients differ from those from non-allergic individuals by genuinely reduced barrier function. By contrast, we found that... -
- CITED
-
- Close
- SHARE
-
- Close
- Epithelial PI3K-δ Promotes House Dust Mite-Induced Allergic Asthma in NLRP3 Inflammasome-Dependent and -Independent Manners
-
Kim SR, Park HJ, Lee KB, Kim HJ, Jeong JS, Cho SH, Lee YC
- KMID: 2468466
- Allergy Asthma Immunol Res.
- 2020 Mar;12(2):338-358.
- doi: 10.4168/aair.2020.12.2.338
PURPOSE: Phosphoinositide 3-kinase (PI3K)-δ-dependent Akt activation is known to play critical roles in various immune responses of white blood cells in which PI3K-δ isoform is mostly expressed in contrast to... -
- CITED
-
- Close
- SHARE
-
- Close
- Heterogeneity of Human γδ T Cells and Their Role in Cancer Immunity
-
Lee HW, Chung YS, Kim TJ
- KMID: 2471045
- Immune Netw.
- 2020 Feb;20(1):e5.
- doi: 10.4110/in.2020.20.e5
The γδ T cells are unconventional lymphocytes that function in both innate and adaptive immune responses against various intracellular and infectious stresses. The γδ T cells can be exploited as... -
- CITED
-
- Close
- SHARE
-
- Close
- Increased Expression of Interleukin-12 in Lesional Skin of Atopic Dermatitis Patients with Psoriasiform Features on Histopathology: An Immunohistochemical Study
-
Lim HJ, Han MH, Lee EH, Eun DH, Kim JY, Lee WJ, Lee SJ, Kim DW, Park TI, Kim SH, Jang YH
- KMID: 2467198
- Ann Dermatol.
- 2020 Feb;32(1):31-37.
- doi: 10.5021/ad.2020.32.1.31
BACKGROUND: Based on clinical and genetic differences, atopic dermatitis (AD) and psoriasis have been classified in two different diseases, but recently, some authors regarded them as in one spectrum. The... -
- CITED
-
- Close
- SHARE
-
- Close
- Characteristics of Pruritus according to Morphological Phenotype of Psoriasis and Association with Neuropeptides and Interleukin-31
-
Park SM, Kim GW, Kim HS, Ko HC, Kim MB, Kim BS
- KMID: 2467194
- Ann Dermatol.
- 2020 Feb;32(1):1-7.
- doi: 10.5021/ad.2020.32.1.1
BACKGROUND: Pruritus is a common symptom in psoriasis. However, few studies have assessed the characteristics of pruritus according to morphological phenotypes of psoriasis. OBJECTIVE: To investigate the characteristics of pruritus according... -
- CITED
-
- Close
- SHARE
-
- Close
- Differential Activation of Macrophages Based on Their Environment in Advanced Age
-
Lee DY, Lim JS, Cho KA
- KMID: 2468141
- Chonnam Med J.
- 2020 Jan;56(1):12-19.
- doi: 10.4068/cmj.2020.56.1.12
The macrophage displays functional and phenotypic diversity, which appears, in no small part, to stem from the ability of macrophages to adapt functionally to changes in their tissue microenvironment. Here,... -
- CITED
-
- Close
- SHARE
-
- Close
- Bordetella bronchiseptica is a potent and safe adjuvant that enhances the antigen-presenting capability of dendritic cells
-
Lee YJ, Han Y, Joo HG
- KMID: 2466569
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):47-52.
- doi: 10.4196/kjpp.2020.24.1.47
We previously demonstrated that Bordetella bronchiseptica (B. bronchiseptica) antigen (Ag) enhances the Mycoplasma hyopneumoniae Ag-specific immune response. The focus of this study was whether acellular bacterin of B. bronchiseptica could... -
- CITED
-
- Close
- SHARE
-
- Close
- Inhibitory effect of carvacrol on lipopolysaccharide-induced memory impairment in rats
-
Lee B, Yeom M, Shim I, Lee H, Hahm DH
- KMID: 2466567
- Korean J Physiol Pharmacol.
- 2020 Jan;24(1):27-37.
- doi: 10.4196/kjpp.2020.24.1.27
Neuroinflammation is an important process underlying a wide variety of neurodegenerative diseases. Carvacrol (CAR) is a phenolic monoterpene commonly used as a food additive due to its antibacterial properties, but... -
- CITED
-
- Close
- SHARE
-
- Close
- Antibiotics-Induced Dysbiosis of Intestinal Microbiota Aggravates Atopic Dermatitis in Mice by Altered Short-Chain Fatty Acids
-
Kim HJ, Lee SH, Hong SJ
- KMID: 2462578
- Allergy Asthma Immunol Res.
- 2020 Jan;12(1):137-148.
- doi: 10.4168/aair.2020.12.1.137
PURPOSE: Alterations in the intestinal microbiota in early life affects the development of atopic dermatitis (AD) in humans. This study aimed to further investigate the effects of gut dysbiosis in... -
- CITED
-
- Close
- SHARE
-
- Close
- Circulating MicroRNAs and T-Cell Cytokine Expression Are Associated With the Characteristics of Asthma Exacerbation
-
Wardzyńska A, Pawełczyk M, Rywaniak J, Kurowski M, Makowska J, Kowalski M
- KMID: 2462577
- Allergy Asthma Immunol Res.
- 2020 Jan;12(1):125-136.
- doi: 10.4168/aair.2020.12.1.125
PURPOSE: Immunological mechanisms underlying asthma exacerbation have not been elucidated. The aim of this study was to assess the associations of various asthma exacerbation traits with selected serum microRNA (miRNA)... -
- CITED
-
- Close
- SHARE
-
- Close
- Particulate Matter 2.5 Causes Deficiency in Barrier Integrity in Human Nasal Epithelial Cells
-
Xian M, Ma S, Wang K, Lou H, Wang Y, Zhang L, Wang C, Akdis CA
- KMID: 2462572
- Allergy Asthma Immunol Res.
- 2020 Jan;12(1):56-71.
- doi: 10.4168/aair.2020.12.1.56
PURPOSE: The effect of air pollution-related particulate matter (PM) on epithelial barrier function and tight junction (TJ) expression in human nasal mucosa has not been studied to date. This study... -
- CITED
-
- Close
- SHARE
-
- Close
- Baicalein Treatment Promotes Osteoblast Proliferation and Osteogenic Differentiation through Activation of Immediate Early Response 3
-
Lee SI
- KMID: 2469741
- J Dent Hyg Sci.
- 2019 Dec;19(4):254-260.
- doi: 10.17135/jdhs.2019.19.4.254
BACKGROUND: The primary aims of periodontal disease treatment is to remove dental plaque and calculus, the main causes of tooth loss, and restore periodontal tissue destroyed by inflammation. Periodontal disease... -
- CITED
-
- Close
- SHARE
-
- Close
- Anti-arthritic Effects of Oplopanax elatus in a Rat Model of Rheumatoid Arthritis (Adjuvant-induced Arthritis)
-
Kwon KS, Lim H, Kwon YS, Choi HR, Kim MJ, Yoo JH, Yoo NH, Kim HP
- KMID: 2468063
- Nat Prod Sci.
- 2019 Dec;25(4):304-310.
- doi: 10.20307/nps.2019.25.4.304
The stems of Oplopanax elatus (OE) have long been used to treat inflammatory disorders in herbal medicine, and in the previous investigation, OE was found to possess anti-inflammatory activity in... -
- CITED
-
- Close
- SHARE
-
- Close
- Aralia cordata Extract Activates NF-κB and MAPK Signaling Pathways and Induces Pro-inflammatory Changes in RAW264.7 Macrophages
-
Seo DW, Cho YI, Yi YJ, Lee SM
- KMID: 2468022
- J Bacteriol Virol.
- 2019 Dec;49(4):153-161.
- doi: 10.4167/jbv.2019.49.4.153
Macrophages play essential roles in innate immune responses by producing various immune mediators. Therefore, modulating macrophage function is an attractive strategy to treat immune disorders. Aralia cordata var. continentalis (AC),... -
- CITED
-
- Close
- SHARE
-
- Close
