- Therapeutic Target for Regulating IL-17 Expression in Asthma: Phosphoinositide 3-Kinase and Peroxisome Proliferator-Activated Receptor Activator gamma
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- KMID: 2299558
- Korean J Asthma Allergy Clin Immunol.
- 2009 Sep;29(3):157-163.
No abstract available. -
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- Role of IL-23 and Th17 Cells in Airway Inflammation in Asthma
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Nakajima H, Hirose K
- KMID: 1456191
- Immune Netw.
- 2010 Feb;10(1):1-4.
- doi: 10.4110/in.2010.10.1.1
Asthma is characterized by chronic airway inflammation with intense eosinophil and lymphocyte infiltration, mucus hyperproduction, and airway hyperresponsiveness. Accumulating evidence indicates that antigen-specific Th2 cells and their cytokines such as... -
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- Regulation of Osteoclast Differentiation by Cytokine Networks
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Amarasekara DS, Yun H, Kim S, Lee N, Kim H, Rho J
- KMID: 2404891
- Immune Netw.
- 2018 Feb;18(1):e8.
- doi: 10.4110/in.2018.18.e8
Cytokines play a pivotal role in maintaining bone homeostasis. Osteoclasts (OCs), the sole bone resorbing cells, are regulated by numerous cytokines. Macrophage colony-stimulating factor and receptor activator of NF-κB ligand... -
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- Insulin Resistance and Serum Levels of Interleukin-17 and Interleukin-18 in Normal Pregnancy
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Jahromi AS, Shojaei M, Ghobadifar MA
- KMID: 2168026
- Immune Netw.
- 2014 Jun;14(3):149-155.
- doi: 10.4110/in.2014.14.3.149
We performed this study to evaluate the role of Interleukin-17 (IL-17) and Interleukin-18 (IL-18) in insulin resistance during normal pregnancy. This descriptive cross sectional study was carried out on 97... -
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- Targeting Interleukin-17 and Th17 in Immune Inflammatory Diseases
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Cho MR
- KMID: 2168216
- Hanyang Med Rev.
- 2013 Feb;33(1):17-26.
- doi: 10.7599/hmr.2013.33.1.17
Th17 cells (Th17) are a distinct lineage of CD4+ T cells that secrete high amounts of IL-17 under orphan nuclear receptor retinoic acid receptor-related orphan receptor gammat (RORgammat) which is... -
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- The Role of Type 2 Innate Lymphoid Cells in Allergic Diseases
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- KMID: 2299449
- Korean J Asthma Allergy Clin Immunol.
- 2012 Dec;32(4):207-212.
Innate lymphoid cells have recently been identified to be a cell population that has morphology typical of lymphocytes but lacks rearranged antigen receptors. It can be classified into RORgammat innate... -
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- The Effects of Interleukin-17 on Production of Vascular Endothelial Growth Factor in Cultured Rheumatoid Arthritis Synoviocytes
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Kwak IS, Nam TS, Rha HY, Suh JT, Kim YS, Kim SI
- KMID: 1945274
- J Korean Rheum Assoc.
- 2001 Sep;8(3):160-168.
OBJECTIVE: To investigate the the effects of interleukin-17 (IL-17)on the production of vascular endothelial growth factor (VEGF)from cultured rheumatoid arthritis synoviocytes. METHODS: Fibroblast-like synovial cells(FLS)were prepared from the synovial tissues... -
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- Interleukin 17-expressing Innate Synovial Cells Drive K/Bxn Serum-induced Arthritis
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Cho WS, Jang E, Kim HY, Youn J
- KMID: 2362801
- Immune Netw.
- 2016 Dec;16(6):366-372.
- doi: 10.4110/in.2016.16.6.366
K/BxN serum can induce arthritis in normal mice because of abundant autoantibodies that trigger an innate inflammatory response in joints. To determine whether IL-17 is involved in the pathogenesis of... -
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- Associations Between Circulating Interleukin-17 Levels and Systemic Lupus Erythematosus and Between Interleukin-17 Gene Polymorphisms and Disease Susceptibility: A Meta-analysis
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Lee YH, Song GG
- KMID: 2471960
- J Rheum Dis.
- 2020 Jan;27(1):37-44.
- doi: 10.4078/jrd.2020.27.1.37
OBJECTIVE: To systematically investigate the relationship between circulating interleukin-17 (IL-17) levels and systemic lupus erythematosus (SLE) and associations between polymorphisms in IL17 genes and SLE susceptibility. METHODS: We performed a meta-analysis... -
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- A Case of Moderate Hidradenitis Suppurativa and Psoriasis Treated with Secukinumab
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Giuseppe P, Nicola P, Valentina , Elena C, Salvatrice C, Rosario G, Rita BM
- KMID: 2457525
- Ann Dermatol.
- 2018 Aug;30(4):462-464.
- doi: 10.5021/ad.2018.30.4.462
Hidradenitis suppurativa (HS) is a disorder of the apocrine gland causing a chronic, recurrent and painful inflammation. It is a disabilitating condition and, though many therapeutic options are available, the... -
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- Reduced Interleukin-17 and Transforming Growth Factor Beta Levels in Peripheral Blood as Indicators for Following the Course of Bladder Cancer
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Baharlou R, Vasmehjani AA, Dehghani A, Ghobadifar MA, Khoubyari
- KMID: 2168027
- Immune Netw.
- 2014 Jun;14(3):156-163.
- doi: 10.4110/in.2014.14.3.156
Interleukin (IL) 17 is produced by T-helper (Th) 17 with a vigorous effect on cells of the immune system playing important roles in pathogenesis of immune-mediated diseases, including autoimmune disorders... -
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- Mouse Model of IL-17-Dominant Rhinitis Using Polyinosinic-Polycytidylic Acid
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Bae JS, Kim EH, Kim JH, Mo JH
- KMID: 2421665
- Allergy Asthma Immunol Res.
- 2017 Nov;9(6):540-549.
- doi: 10.4168/aair.2017.9.6.540
Interleukin (IL)-17 plays an important role in rhinitis and the level thereof correlates with the severity of disease. However, no mouse model for IL-17-dominant rhinitis has yet been developed. Our... -
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- The Th17 and Autoimmune Arthritis
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Cho ML, Heo YJ, Park JS, Lee SY, Sung YC, Kim HY
- KMID: 2150622
- Immune Netw.
- 2007 Mar;7(1):10-17.
- doi: 10.4110/in.2007.7.1.10
Autoimmune arthritis, such as rheumatoid arthritis (RA), is a chronic inflammatory disorder that primarily affects the joints and then results in their progressive destruction. Effector Th cells have been classified... -
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- Interleukin-17 in the Inflammatory Bowel Disease
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Lee CR, Park SG
- KMID: 2168217
- Hanyang Med Rev.
- 2013 Feb;33(1):27-32.
- doi: 10.7599/hmr.2013.33.1.27
Inflammatory bowel diseases(IBD), including Crohn's disease and ulcerative colitis, are chronic inflammatory states of the intestinal tract. While the exact mechanisms inducing chronic inflammation are still unclear, it is hypothesized... -
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- The Effects of Interleukin-17 on Production of Matrix Metalloproteinase-3 in Cultured Rheumatoid Arthritis Synoviocytes
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Ryu S, Kim SI
- KMID: 2202348
- J Korean Rheum Assoc.
- 2004 Mar;11(1):1-6.
OBJECTIVE: To investigate the effect of interleukin-17 (IL-17) on the production of matrix metalloproteinase-3 (MMP-3) and the expression of MMP-3 mRNA in rheumatoid arthritis synoviocytes. METHODS: Fibroblast-like synovial cells (FLS)... -
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- A Case of Rapid Progressive Neurosyphilis in Patient with Ankylosing Spondylitis Who Is Treating Anti-interleukin 17A Monoclonal Antibody, Secukinumab
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Lee SJ, Park HK, Kim YS
- KMID: 2459453
- J Rheum Dis.
- 2019 Oct;26(4):278-281.
- doi: 10.4078/jrd.2019.26.4.278
Anti-interleukin 17A agent, secukinumab is remarkably effective for treating patients with ankylosing spondylitis. However, the main safety concern of secukinumab is an increased risk of infection. Generally, neurosyphilis occurs a... -
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- IL-23 P19 Expression Induced by IL-17 and IL-1beta in Rheumatoid Arthritis Synovial Mononuclear Cells
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Cho ML, Heo YJ, Oh HJ, Kang CM, Lee SY, Hong YS, Kim HY
- KMID: 2054256
- Immune Netw.
- 2008 Mar;8(1):29-37.
- doi: 10.4110/in.2008.8.1.29
Interleukin-23 (IL-23) is a novel pro-inflammatory cytokine which has been implicated to play a pathogenic role in rheumatoid arthritis (RA). This study was undertaken to investigate the IL-23 inductive activity... -
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- Association between polymorphisms in Interleukin-17 receptor A gene and childhood IgA nephropathy
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Baek SA, Hahn WH, Cho BS, Kim SD
- KMID: 2281369
- Korean J Pediatr.
- 2010 Feb;53(2):215-221.
- doi: 10.3345/kjp.2010.53.2.215
PURPOSE: Interleukin-17 (IL-17) is produced by activated CD4+T cells and exhibits pleiotropic biological activity on various cell types. IL-17 was reported to be involved in the immunoregulatory response in IgA... -
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- IL-17-Producing Cells in Tumor Immunity: Friends or Foes?
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Kuen DS, Kim BS, Chung Y
- KMID: 2471046
- Immune Netw.
- 2020 Feb;20(1):e6.
- doi: 10.4110/in.2020.20.e6
IL-17 is produced by RAR-related orphan receptor gamma t (RORγt)-expressing cells including Th17 cells, subsets of γδT cells and innate lymphoid cells (ILCs). The biological significance of IL-17-producing cells is... -
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- Effects of Interleukin-9 Blockade on Chronic Airway Inflammation in Murine Asthma Models
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Kim MS, Cho KA, Cho YJ, Woo SY
- KMID: 2260312
- Allergy Asthma Immunol Res.
- 2013 Jul;5(4):197-206.
- doi: 10.4168/aair.2013.5.4.197
PURPOSE: Asthma is a chronic inflammatory disease of the airways associated with structural changes and airway remodeling. Interleukin (IL)-9 has pleiotropic effects on both inflammatory cells and airway structural cells,... -
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