Lab Anim Res.  2011 Dec;27(4):301-307. 10.5625/lar.2011.27.4.301.

Effects of Sigma Anti-bonding Molecule Calcium Carbonate on bone turnover and calcium balance in ovariectomized rats

Affiliations
  • 1College of Veterinary Medicine and Veterinary Medical Center, Chungbuk National University, Cheongju, Korea. kang6467@cbu.ac.kr
  • 2Department of Biomedical Laboratory Science, Daejeon University, Daejeon, Korea.
  • 3NTS Research & Inc., Coquitlam, British Columbia, Canada.

Abstract

This study was conducted to evaluate the effect of Sigma Anti-bonding Molecule Calcium Carbonate (SAC) as therapy for ovariectomy-induced osteoporosis in rats. Three weeks after surgery, fifteen ovariectomized Sprague-Dawley rats were divided randomly into 3 groups: sham-operated group (sham), ovariectomized group (OVX) and SAC-treatment group (OVX+SAC). The OVX+SAC group was given drinking water containing 0.0012% SAC for 12 weeks. Bone breaking force and mineralization as well as blood parameters related to the bone metabolism were analyzed. In OVX animals, blood concentration of 17beta-estradiol decreased significantly, while osteocalcin and type I collagen C-terminal telopeptides (CTx) increased. Breaking force, bone mineral density (BMD), calcium and phosphorus in femurs, as well as uterine and vaginal weights, decreased significantly following OVX. However, SAC treatment (0.0012% in drinking water) not only remarkably restored the decreased 17beta-estradiol and increased osteocalcin and CTx concentrations, but also recovered decreased femoral breaking force, BMD, calcium and phosphorus, although it did not reversed reproductive organ weights. It is suggested that SAC effectively improve bone density by preventing bone turnover mediated osteocalcin, CTx and minerals, and that it could be a potential candidate for therapy or prevention of postmenopausal osteoporosis.

Keyword

Osteoporosis; bone mineral density; Sigma Anti-bonding Molecule Calcium Carbonate; 17beta-estradiol; osteocalcin; type I collagen C-terminal telopeptides
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