Osteoporosis.  2011 Apr;9(1):107-114.

Effects of Nano-sized Calcium on Intestinal Absorption and Bone Turnover

  • 1Department of Family Medicine, Konyang University Hospital, College of Medicine, Konyang University, Daejeon, Korea. jeehyunkang@yahoo.co.kr


We compared the effects of two different nano-sized calcium supplements (synthesized by wet-chemical method or the dry-grinding method of calcium carbonate) and one micro-sized calcium supplement (calcium carbonate) on intestinal absorption and bone turnover in 20 young women. MATERIALS & METHODS: This study was carried out with a three week cross-over design. The subjects ingested one of three different calcium supplements (1 dose of 500 mg Ca++) at 8 AM, which was repeated three times weekly. Serum and urine samples were collected before and after the calcium load using a time table (serum sampling 0, 2 hr, 4 hr, 8 hr after loading; urine sampling 0, 4 hr, 8 hr after loading).
Serum ionized calcium and parathyroid hormone concentrations significantly changed in response to all calcium supplements loading, the difference among calcium supplements was not significant. However, the postload urinary excretion of calcium and the N-telopeptide/creatinine ratio were significantly different among three calcium supplement over time by repeated measured ANOVA.
The results of this study suggest the effect of nano-sized calcium supplements synthesized by the wet-chemical method is superior to the other calcium supplements in intestinal calcium absorption and bone turn-over.


Nano-calcium by wet-chemical method; Nano-calcium by dry grinding method; Calcium absorption; Bone-turnover
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