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Establishment of NOAEL for intracavernous injections of human bone marrow-derived mesenchymal stem cells in rats

Kim JK, Jang MJ, Kim BH, Choi KR, Song G, Shin HC, Suh N, Kim YM, You D, Ahn TY, Kim CS

PURPOSE: To assess the possible negative health effects of human bone marrow-derived mesenchymal stem cells (hBMSCs) on fertility and early embryonic development following intracavernous injections in rats. MATERIALS AND METHODS: A...
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Effect of melatonin on the onset of puberty in male juvenile rats

Venugopal

Melatonin or N-acetyl-5-methoxytryptamine, the fascinating molecule secreted by the pineal gland. Melatonin has a close interaction with hypothalamic-pituitary-gonadal axis. In non-seasonal breeders like rat its exact role in reproduction is...
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Effect of Yeonsan Ogye bioactive peptides on anti-oxidant indexes in rats' liver

Kim HW, Shim JH, Kim KN

PURPOSE: This study investigated the effect of bioactive Yeonsan Ogye peptides (YOPs) intake on changes in the hepatic anti-oxidant indexes in male rats. METHODS: Sprague-Dawley male rats were divided into 3...
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Evaluation of Acute and Sub-acute Oral Toxicity Effect of Aquilaria malaccensis Leaves Aqueous Extract in Male ICR Mice

Musa NH, Zain HH, Ibrahim H, Jamil NN

The study was conducted to investigate the acute and sub-acute toxicity effect of Aquilaria malaccensis leaves aqueous extract (AEAM) towards male ICR mice in terms of body weight, relative organ...
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Pharmacodynamic principles and target concentration intervention

Holford N

This tutorial reviews the principles of dose individualisation with an emphasis on target concentration intervention (TCI). Once a target effect is chosen then pharmacodynamics can predict the target concentration and...
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Ginkgo biloba extract (EGb761) did not express estrogenic activity in an immature rat uterotrophic assay

Moon B, Kim W, Park CH, Oh SM

Ginkgo biloba is a dioecious tree that has been used in traditional Chinese medicine for about 5,000 years. In previous studies on Ginkgo biloba extract (EGb761) using in vitro systems,...
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Resection plane-dependent error in computed tomography volumetry of the right hepatic lobe in living liver donors

Kwon HJ, Kim KW, Kim B, Kim SY, Lee CS, Lee J, Song GW, Lee SG

BACKGROUND/AIMS: Computed tomography (CT) hepatic volumetry is currently accepted as the most reliable method for preoperative estimation of graft weight in living donor liver transplantation (LDLT). However, several factors can...
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Hippo pathway coactivators Yap and Taz are required to coordinate mammalian liver regeneration

Lu L, Finegold M, Johnson RL

The mammalian liver has a remarkable capacity for repair following injury. Removal of up to two-third of liver mass results in a series of events that include extracellular matrix remodeling,...
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Acute and 13-week subchronic toxicological evaluations of turanose in mice

Chung JY, Lee J, Lee D, Kim E, Shin JH, Seok PR, Yoo SH, Kim Y

BACKGROUND/OBJECTIVES: Turanose, α-D-glucosyl-(1→3)-α-D-fructose, is a sucrose isomer which naturally exists in honey. To evaluate toxicity of turanose, acute and subchronic oral toxicity studies were conducted with ICR mice. MATERIALS AND METHODS:...
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Antihypertensive effect of ethanol extracts of Aralia elata in spontaneously hypertensive rats

Jin JY, Park EH, Jeon YA, Lee YJ

Antihypertensive effects of ethanol extracts of Aralia elata (Miq.) Seem. (AE) were investigated in spontaneously hypertensive rats (SHR). SHR aged 14 weeks were treated for 8 weeks with AE (10...
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Preclinical safety assessment of Angelica acutiloba using a 13-week repeated dose oral toxicity study in rats

Yun JW, Kwon E, Kim SH, You JR, Kim YS, Park IA, Kim HH, Che JH, Kang BC

Angelica acutiloba (AA), a Japanese species of Danggui, has been used worldwide as a traditional herbal medicine with several bioactivities including anti-diabetic, anti-allergic, anti-inflammatory, anti-tumor, and anti-obesity. However, there is...
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Improved Antitumor Efficacy of Hyaluronic Acid-Complexed Paclitaxel Nanoemulsions in Treating Non-Small Cell Lung Cancer

Kim JE, Park YJ

Paclitaxel (PTX) is a effectively chemotherapeutic agent which is extensively able to treat the non-small cell lung, pancreatic, breast and other cancers. But it is a practically insoluble drug with...
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Alterations in antioxidant function and cell apoptosis in duck spleen exposed to molybdenum and/or cadmium

Zhang M, Luo J, Zhang C, Cao H, Xia B, Hu G

To investigate the effects of molybdenum (Mo) and/or cadmium (Cd) on antioxidant function and the apoptosis-related genes in duck spleens. Sixty healthy 11-day-old ducks were randomly divided into six groups...
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Comparative study of fertilization rates of C57BL/6NKorl and C57BL/6N mice obtained from two other sources

Yun WB, Kim HR, Kim JE, Choi JY, Lee MR, Park JJ, Song BR, Jung YS, Song HK, Cho JY, Kim KS, Hwang DY

C57BL/6N is the most widely used inbred mouse strain applied in a wide variety of research areas including cancer, cardiovascular biology, developmental biology, diabetes and obesity, genetics, immunology, neurobiology, and...
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Hepatotoxicity and nephrotoxicity of saponin-enriched extract of Asparagus cochinchinensis in ICR mice

Sung JE, Choi JY, Kim JE, Lee HA, Yun WB, Park JJ, Kim HR, Song BR, Kim DS, Lee CY, Lee HS, Lim Y, Hwang DY

The inhibitory effects of Asparagus cochinchinensis against inflammatory response induced by lipopolysaccharide (LPS), substance P and phthalic anhydride (PA) treatment were recently reported for some cell lines and animal models....
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The correlation between preoperative volumetry and real graft weight: comparison of two volumetry programs

Mussin N, Sumo M, Lee KW, Choi Y, Choi JY, Ahn SW, Yoon KC, Kim HS, Hong SK, Yi NJ, Suh KS

PURPOSE: Liver volumetry is a vital component in living donor liver transplantation to determine an adequate graft volume that meets the metabolic demands of the recipient and at the same...
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Comparison of commonly used ICR stocks and the characterization of Korl:ICR

Shin HJ, Cho YM, Shin HJ, Kim HD, Choi KM, Kim MG, Shin HD, Chung MW

Mouse is a commonly used animal in life science studies and is classified as outbred if genetically diverse and inbred if genetically homogeneous. Outbred mouse stocks, are used in toxicology,...
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Assessing the accuracy and reliability of ultrasonographic three-dimensional parathyroid volume measurement in a patient with secondary hyperparathyroidism: a comparison with the two-dimensional conventional method

You SH, Suh SI, Ryoo IS, Son GR, Lee YH, Seo HS, Lee NJ, Seol HY

PURPOSE: The purpose of this study was to investigate the accuracy and reliability of the semi-automated ultrasonographic volume measurement tool, virtual organ computer-aided analysis (VOCAL), for measuring the volume of...
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Anthropometric Study of the Stomach

Lee EG, Kim TH, Huh YJ, Suh YS, Ahn HS, Kong SH, Lee HJ, Kim WH, Yang HK

PURPOSE: The aim of this study was to establish an anthropometric reference of the stomach for gastric cancer surgery and a modeling formula to predict stomach length. MATERIALS AND METHODS: Data...
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Human Adipose-derived Mesenchymal Stem Cells Attenuate Early Stage of Bleomycin Induced Pulmonary Fibrosis: Comparison with Pirfenidone

Reddy M, Fonseca L, Gowda S, Chougule B, Hari A, Totey S

BACKGROUND AND OBJECTIVES: Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible, invariably fatal fibrotic lung disease with no lasting option for therapy. Mesenchymal stem cells (MSCs) could be a promising...
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