Osong Public Health Res Perspect.  2019 Feb;10(1):6-11. 10.24171/j.phrp.2019.10.1.03.

Natural Infection with Rabies Virus: A Histopathological and Immunohistochemical Study of Human Brains

Affiliations
  • 1Collaborating Center for Reference and Research on Rabies, Pasteur Institute of Iran, Tehran, Iran.
  • 2Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
  • 3Department of Virology, Golestan University of Medical Sciences, Gorgan, Iran.
  • 4Department of Pathology, School of Veterinary Medicine, Shahrekord University, Shahrekord, Iran.
  • 5Molecular Research Center, Student Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
  • 6Department of Neurosurgery and Neurology, Westfälische Wilhelms-Universität Münster, Münster, Germany.
  • 7Department of Immunology, Pasteur Institute of Iran, Tehran, Iran.
  • 8Department of Virology, Pasteur Institute of Iran, Tehran, Iran. ghaem_amir@yahoo.com

Abstract


OBJECTIVES
Despite all the efforts and increased knowledge of rabies, the exact mechanisms of infection and mortality from the rabies virus are not well understood. To understand the mechanisms underlying the pathogenicity of rabies virus infection, it is crucial to study the tissue that the rabies virus naturally infects in humans.
METHODS
Cerebellum brain tissue from 9 human post mortem cases from Iran, who had been infected with rabies virus, were examined histopathologically and immunohistochemically to evaluate the innate immune responses against the rabies virus.
RESULTS
Histopathological examination revealed inflammation of the infected cerebellum and immunohistochemical analyses showed an increased immunoreactivity of heat shock protein 70, interleukin-6, interleukin-1, tumor necrosis factor-alpha, caspase-3, caspase-9, toll-like receptor3 and toll-like receptor4 in the infected brain tissue.
CONCLUSION
These results indicated the involvement of innate immunity in rabies infected human brain tissue, which may aggravate the progression of this deadly disease.

Keyword

central nervous system; human; immunohistochemistry; pathology; rabies; tissue

MeSH Terms

Brain*
Caspase 3
Caspase 9
Central Nervous System
Cerebellum
HSP70 Heat-Shock Proteins
Humans*
Immunity, Innate
Immunohistochemistry
Inflammation
Interleukin-1
Interleukin-6
Iran
Mortality
Pathology
Rabies virus*
Rabies*
Tumor Necrosis Factor-alpha
Virulence
Caspase 3
Caspase 9
HSP70 Heat-Shock Proteins
Interleukin-1
Interleukin-6
Tumor Necrosis Factor-alpha
Full Text Links
  • OPHRP
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr