- Heat shock protein 70 increases cell proliferation, neuroblast differentiation, and the phosphorylation of CREB in the hippocampus
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Kwon HJ, Kim W, Jung HY, Kang MS, Kim JW, Hahn KR, Yoo DY, Yoon YS, Hwang IK, Kim DW
- KMID: 2470012
- Lab Anim Res.
- 2019 Dec;35(4):154-164.
- doi: 10.1186/s42826-019-0020-2
In the present study, we investigated the effects of heat shock protein 70 (HSP70) on novel object recognition, cell proliferation, and neuroblast differentiation in the hippocampus. To facilitate penetration into... -
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- Role of Immunosuppressive Microenvironment in Acquiring Immunotolerance Post-Photothermal Therapy
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Cherukula , Park MS, Sontyana A, Mathew AP, Vijayan V, Bae WK, Park IK
- KMID: 2462185
- J Korean Med Sci.
- 2019 Nov;34(44):e272.
- doi: 10.3346/jkms.2019.34.e272
BACKGROUND: Nanoparticle-mediated photothermal therapy (PTT) has been well studied as a treatment for cancer. However, the therapeutic outcome of PTT is often hindered by the penetration depth of laser light.... -
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- MicroRNA-16 inhibits cell proliferation and migration by targeting heat shock protein 70 in heat-denatured dermal fibroblasts
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Zhang C, Dai J, Fan Y, He X, Wei R
- KMID: 2448356
- Korean J Intern Med.
- 2019 May;34(3):634-642.
- doi: 10.3904/kjim.2016.315
BACKGROUND/AIMS: This study aimed to investigate the precise mechanism and function of miR-16 in heat-denatured primary human dermal fibroblasts. METHODS: Primary human dermal fibroblasts were separated from normal human skin samples.... -
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- Effects of heme oxygenase-1 upregulation on isoproterenol-induced myocardial infarction
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Eltobshy S, Hussein AM, Elmileegy , Askar MH, Khater Y, Metias EF, Helal GM
- KMID: 2443608
- Korean J Physiol Pharmacol.
- 2019 May;23(3):203-217.
- doi: 10.4196/kjpp.2019.23.3.203
The present study was designed to examine the effect of heme oxygenase-1 (HO-1) induction by cobalt protoporphyrin (CoPP) on the cardiac functions and morphology, electrocardiogram (ECG) changes, myocardial antioxidants (superoxide... -
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- Natural Infection with Rabies Virus: A Histopathological and Immunohistochemical Study of Human Brains
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Farahtaj F, Alizadeh L, Gholami A, Tahamtan A, Shirian S, Fazeli M, Nejad AS, Gorji A, Niknam HM, Ghaemi A
- KMID: 2441507
- Osong Public Health Res Perspect.
- 2019 Feb;10(1):6-11.
- doi: 10.24171/j.phrp.2019.10.1.03
OBJECTIVES: Despite all the efforts and increased knowledge of rabies, the exact mechanisms of infection and mortality from the rabies virus are not well understood. To understand the mechanisms underlying... -
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- Immediate Effects of a Single Exercise on Behavior and Memory in the Early Period of Traumatic Brain Injury in Rats
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Yoon KJ, Kim DY
- KMID: 2429193
- Ann Rehabil Med.
- 2018 Oct;42(5):643-651.
- doi: 10.5535/arm.2018.42.5.643
OBJECTIVE: To evaluate the immediate effect of single exercise on physical performance and memory in the early stage of traumatic brain injury (TBI) in rats. METHODS: Ninety TBI rats were randomly... -
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- S100ß, Matrix Metalloproteinase-9, D-dimer, and Heat Shock Protein 70 Are Serologic Biomarkers of Acute Cerebral Infarction in a Mouse Model of Transient MCA Occlusion
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Choi JI, Ha SK, Lim DJ, Kim SD, Kim SH
- KMID: 2420062
- J Korean Neurosurg Soc.
- 2018 Sep;61(5):548-558.
- doi: 10.3340/jkns.2017.0200
OBJECTIVE: Diagnosing acute cerebral infarction is crucial in determining prognosis of stroke patients. Although many serologic tests for prompt diagnosis are available, the clinical application of serologic tests is currently... -
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- Gene Therapy for Hearing Protection
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Lee MY
- KMID: 2386108
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2017 Jun;60(6):263-270.
- doi: 10.3342/kjorl-hns.2017.00514
Sensorineural hearing loss (SNHL) does not recover and only few exceptions exist. It is mostly due to the reason that hair cells in the cochlea cannot regenerate once damaged. Therefore,... -
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- Serial Changes of Heat Shock Protein 70 and Interleukin-8 in Burn Blister Fluid
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Yoo K, Suh KY, Choi GH, Kwak IS, Seo DK, Kym D, Yoon H, Cho YS, Kim HO
- KMID: 2394843
- Ann Dermatol.
- 2017 Apr;29(2):194-199.
- doi: 10.5021/ad.2017.29.2.194
BACKGROUND: It has been reported that heat shock protein 70 (HSP70) and interleukin-8 (IL-8) play an important role in cells during the wound healing process. However, there has been no... -
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- Potential Vaccine Targets against Rabbit Coccidiosis by Immunoproteomic Analysis
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Song H, Dong R, Qiu B, Jing J, Zhu S, Liu C, Jiang Y, Wu L, Wang S, Miao J, Shao Y
- KMID: 2374798
- Korean J Parasitol.
- 2017 Feb;55(1):15-20.
- doi: 10.3347/kjp.2017.55.1.15
The aim of this study was to identify antigens for a vaccine or drug target to control rabbit coccidiosis. A combination of 2-dimensional electrophoresis, immunoblotting, and mass spectrometric analysis were... -
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- Expression of CAIII and Hsp70 Is Increased the Mucous Membrane of the Posterior Commissure in Laryngopharyngeal Reflux Disease
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Min HJ, Hong SC, Yang HS, Mun SK, Lee SY
- KMID: 2374055
- Yonsei Med J.
- 2016 Mar;57(2):469-474.
- doi: 10.3349/ymj.2016.57.2.469
PURPOSE: We tried to evaluate the difference in the expression of carbonic anhydrase (CA) III and heat shock protein (Hsp) 70 between laryngopharyngeal reflux disease (LPRD) and non-LPRD patients. MATERIALS AND... -
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- Hsp70 Knockdown by siRNA Decreased Collagen Production in Keloid Fibroblasts
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Shin JU, Lee WJ, Tran TN, Jung I, Lee JH
- KMID: 2345891
- Yonsei Med J.
- 2015 Nov;56(6):1619-1626.
- doi: 10.3349/ymj.2015.56.6.1619
PURPOSE: There are currently no consistently effective treatments for the excessive collagen produced by keloid fibroblasts. Previously, we reported that heat shock protein 70 (Hsp70) is up-regulated in keloid fibroblasts... -
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- The Prognostic Impact of Heat Shock Proteins Expression in Patients with Esophageal Cancer: A Meta-Analysis
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Wang XW, Shi XH, Tong YS, Cao XF
- KMID: 2345875
- Yonsei Med J.
- 2015 Nov;56(6):1497-1502.
- doi: 10.3349/ymj.2015.56.6.1497
PURPOSE: Heat shock proteins (HSPs) are highly conserved molecular chaperones. There are various studies that assess the prognostic value of HSPs in patients with esophageal cancer, but the conclusion remains... -
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- The Cytotoxicity of Kahweol in HT-29 Human Colorectal Cancer Cells Is Mediated by Apoptosis and Suppression of Heat Shock Protein 70 Expression
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Choi DW, Lim MS, Lee JW, Chun W, Lee SH, Nam YH, Park JM, Choi DH, Kang CD, Lee SJ, Park SC
- KMID: 2380345
- Biomol Ther.
- 2015 Mar;23(2):128-133.
- doi: 10.4062/biomolther.2014.133
Although coffee is known to have antioxidant, anti-inflammatory, and antitumor properties, there have been few reports about the effect and mechanism of coffee compounds in colorectal cancer. Heat shock proteins... -
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- Differentially Expressed Proteins in Nitric Oxide-Stimulated NIH/3T3 Fibroblasts: Implications for Inhibiting Cancer Development
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Shim DH, Lim JW, Kim H
- KMID: 2070039
- Yonsei Med J.
- 2015 Mar;56(2):563-571.
- doi: 10.3349/ymj.2015.56.2.563
PURPOSE: Recent evidence shows that nitric oxide (NO) may exhibit both pro-cancer and anti-cancer activities. The present study aimed to determine the differentially expressed proteins in NO-treated NIH/3T3 fibroblasts in... -
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- The expression of FAS-associated factor 1 and heat shock protein 70 in ovarian cancer
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Kang HJ, Moon HS, Chung HW
- KMID: 1841539
- Obstet Gynecol Sci.
- 2014 Jul;57(4):281-290.
- doi: 10.5468/ogs.2014.57.4.281
OBJECTIVE: In this study, we evaluated the expression of FAS-associated factor 1 (FAF1) and heat shock protein 70 (HSP70) in normal ovary and ovarian cancer, and also analyzed the correlation... -
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- Semi-Quantitative Analyses of Hippocampal Heat Shock Protein-70 Expression Based on the Duration of Ischemia and the Volume of Cerebral Infarction in Mice
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Choi JI, Kim SD, Kim SH, Lim DJ, Ha SK
- KMID: 2191109
- J Korean Neurosurg Soc.
- 2014 Jun;55(6):307-312.
- doi: 10.3340/jkns.2014.55.6.307
OBJECTIVE: We investigated the expression of hippocampal heat shock protein 70 (HSP-70) infarction volume after different durations of experimental ischemic stroke in mice. METHODS: Focal cerebral ischemia was induced in mice... -
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- Identification of abnormal gene expression in bovine transgenic somatic cell nuclear transfer embryos
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Cho J, Kang S, Lee BC
- KMID: 1784643
- J Vet Sci.
- 2014 Jun;15(2):225-231.
- doi: 10.4142/jvs.2014.15.2.225
This study was conducted to investigate the expression of three genes related to early embryonic development in bovine transgenic cloned embryos. To accomplish this, development of bovine transgenic somatic cell... -
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- Prognostic Significance of p53, mTOR, c-Met, IGF-1R, and HSP70 Overexpression after the Resection of Hepatocellular Carcinoma
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Kang GH, Lee BS, Lee ES, Kim SH, Lee HY, Kang DY
- KMID: 1774532
- Gut Liver.
- 2014 Jan;8(1):79-87.
BACKGROUND/AIMS: The current study examines the expression of molecular biomarkers in hepatocellular carcinoma (HCC) and whether these findings correlate with the clinicopathologic features of the disease and patient survival. METHODS: We... -
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- Expression of Heat Shock Protein 70 Modulates the Chemoresponsiveness of Pancreatic Cancer
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Hyun JJ, Lee HS, Keum B, Seo YS, Jeen YT, Chun HJ, Um SH, Kim CD
- KMID: 1712336
- Gut Liver.
- 2013 Nov;7(6):739-746.
BACKGROUND/AIMS: Heat shock protein (HSP) 70 is constitutively overexpressed in pancreatic cancer cells (PCCs) and appears to confer protection against chemotherapeutics. We investigated whether modulating HSP 70 increases chemoresponsiveness to... -
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