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Diagnostic conundrums of schwannomas: two cases highlighting morphological extremes and diagnostic challenges in biopsy specimens of soft tissue tumors

Kim C, Chung YG, Jung CK

Schwannomas are benign, slow-growing peripheral nerve sheath tumors commonly occurring in the head, neck, and flexor regions of the extremities. Although most schwannomas are easily diagnosable, their variable morphology can...
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Prognostic Significance of ARID1A Expression Patterns Varies with Molecular Subtype in Advanced Gastric Cancer

Kim JY, Park CK, Noh S, Cheong JH, Noh SH, Kim H

Background/Aims: AT-rich interactive domain 1A (ARID1A) is frequently mutated in gastric cancer (GC), especially Epstein-Barr virus (EBV)-associated and microsatellite instability high GC. The loss of ARID1A expression has been reported as...
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Comparison of Programmed Cell Death Ligand 1 Status between Core Needle Biopsy and Surgical Specimens of Triple-Negative Breast Cancer

Choi H, Ahn SG, Bae SJ, Kim JH, Eun NL, Lee Y, Nahm JH, Jeong J, Cha YJ

Purpose: Pembrolizumab is currently used to treat advanced triple-negative breast cancer (TNBC) and high-risk early TNBC with neoadjuvant chemotherapy (NAC). The tumor-infiltrating lymphocyte (TIL) level and programmed cell death ligand...
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Loss of aquaporin-1 expression is associated with worse clinical outcomes in clear cell renal cell carcinoma: an immunohistochemical study

Lee S, Kim B, Jung M, Moon KC

Background: Aquaporin (AQP) expression has been investigated in various malignant neoplasms, and the overexpression of AQP is related to poor prognosis in some malignancies. However, the expression of AQP protein...
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Immunohistochemistry versus PCR Technology for Molecular Subtyping of Breast Cancer: Multicentered Expereinces from Addis Ababa, Ethiopia

Oma D, Teklemariam M, Seifu D, Desalegn Z, Anberbir E, Abebe T, Mequannent S, Tebeje S, Labisso WL

The application of immunohistochemistry (IHC) for molecular characterization of breast cancer (BC) is of paramount importance; however, it is not universally standardized, subject to observer variability and quantifying is a...
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A Case of the Development of Porocarcinoma in situ from a Preexisting Hidroacanthoma Simplex: Immunohistochemical Staining to Highlight Malignant Transformation

Park HU, Lee J, Kim W, Kang JW, Ro BI, Cho HK

  • KMID: 2542618
  • Korean J Dermatol.
  • 2023 May;61(4):248-251.
Porocarcinoma is a malignancy of the eccrine sweat gland. It may arise de novo or develop from pre-existing poroma and hidroacanthoma simplex. A 56-year-old woman was presented with a pinkish...
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Immunohistochemical Analysis of the Expression of Cytokeratins in Acquired Cholesteatoma and Its Clinico-Radiological Correlation

Kanodia A, Kakkar A, Verma Y, Roy D, Verma H, Singh CA, Monga R, Jain D, Thakar A, Sikka K

Background and Objectives: Cholesteatomatous chronic otitis media acquires epithelial proliferation and differentiation characteristics, which render it able to erode the underlying bone and cause complications. We attempt to characterize the...
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Hemorrhagic disease caused by bovine viral diarrhea virus-2a in Korean Indigenous Cattle: case reports

Cho HC, Kim BS, Jang DH, Lee KH, Choi KS

Bovine viral diarrhea virus (BVDV), which is prevalent worldwide, is one of the most important viral pathogens and causes substantial economic loss to the livestock industry. Despite its importance, BVDV...
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Evaluation of laboratory diagnostic tests for light-chain clonality and bone marrow findings in AL amyloidosis

Lee T, Park CJ, Kim M, Cho YU, Jang S, Hwang SH, Lee JH, Yoon DH

Background Light-chain amyloidosis (AL) is the most common form of systemic amyloidosis. This study aimed to evaluate the usefulness of laboratory tests for light-chain clonality and bone marrow (BM) findings in...
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Adult hepatoblastoma: making the challenging distinction from hepatocellular carcinoma

Pagarigan AKL, Mendoza PGL

Hepatoblastoma is an exceptionally rare malignancy in adults with just over 70 non-pediatric cases reported in literature. Recounted is a case of a 49-year-old female who presented with acute right...
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Mixed adenoneuroendocrine carcinoma of the ampulla of Vater: Three case reports and a literature review

Sung MK, Lee W, Hong S, Park Y, Kwak BJ, Song KB, Lee JH, Hwang DW, Kim SC

Mixed adenoneuroendocrine carcinoma is defined as a tumor with a mixture of adenocarcinoma components and neuroendocrine neoplasm components. Each of these two components of mixed adenoneuroendocrine carcinoma accounts for at...
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Postoperative Prognostic Predictors of Bile Duct Cancers: Clinical Analysis and Immunoassays of Tissue Microarrays

Chung HH, Seo SH, Kim H, Kim Y, Kim DW, Lee KH, Lee KT, Heo JS, Han IW, Park SM, Jang KT, Lee JK, Park JK

Background/Aims: Cholangiocarcinoma frequently recurs even after curative resection. Expression levels of proteins such as epidermal growth factor receptor (EGFR), Snail, epithelial cadherin (E-cadherin), and interleukin-6 (IL-6) examined by immunohistochemistry have...
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The Distinctive Immunologic Pathogenesis Differentiates Atopic Comorbidity Status in Prurigo Nodularis

Chu H, Kim WJ, Kim SM, Kim SH, Kim JH, Zhang K, Kim HL, Kim RW, Lee KH, Park CO

  • KMID: 2538563
  • Korean J Dermatol.
  • 2022 Dec;60(10):666-674.
Background: Prurigo nodularis (PN) is a chronic pruritic skin disorder with a large number of hyperkeratotic nodules. The precise mechanisms of its pathogenesis remain unknown. PN has been linked to...
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Feline progressive histiocytosis in four cats: case reports

Kim JS, Yim SJ, Kim JH, Jung JY

We describe four cases of feline progressive histiocytosis (FPH) including three females (one intact, two spayed) and one castrated male cat, with a mean age of 5.95 years at diagnosis....
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Evaluation of MET alteration in EGFR-mutant non-small cell lung cancer patients treated with EGFR tyrosine kinase inhibitor from paired biopsy: A retrospective cohort study

Ku BM, Park S, Park S, Jung HA, Sun JM, Lee SH, Ahn JS, Choi YL, Ahn MJ

Purpose: Mesenchymal-epithelial transition tyrosine kinase receptor (MET) amplification is one of the common acquired resistance mechanisms to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). To evaluate the usefulness...
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A clinicopathologic and immunohistochemical study of primary and secondary breast angiosarcoma

Abada E, Jang H, Kim S, Ali-Fehmi R, Bandyopadhyay S

Background: We aimed to study the clinicopathologic and immunohistochemical (IHC) (CD117, c-Myc, and p53) characteristics, and overall survival of primary and secondary breast angiosarcoma (BAS). Methods: This was a retrospective...
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Usefulness of BRAF VE1 immunohistochemistry in non–small cell lung cancers: a multi-institutional study by 15 pathologists in Korea

Chang S, Choi YL, Shim HS, Lee GK, Ha SY, Korean Cardiopulmonary Pathology Study Group

Background: Next-generation sequencing (NGS) is an approved test to select patients for BRAF V600E targeted therapy in Korea. However, the high cost, long turnaround times, and the need for sophisticated...
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Critical diagnostic and cancer stem cell markers in neoplastic cells from canine primary and xenografted pulmonary adenocarcinoma

Tangchang W, Kim Y, Oh YI, Lee BW, Kim H, Yoon B

It is challenging to diagnose metastatic tumors whose cellular morphology is different from the primary. We characterized canine primary pulmonary adenocarcinoma (PAC) and its xenografted tumors by histological and immunohistochemical...
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Lectin histochemistry of the olfactory mucosa of Korean native cattle, Bos taurus coreanae

Jang S, Kim B, Lee J, Kang S, Kim JS, Kim JC, Kim SH, Shin T, Moon C

Background: The olfactory mucosa (OM) is crucial for odorant perception in the main olfactory system. The terminal carbohydrates of glycoconjugates influence chemoreception in the olfactory epithelium (OE). Objectives: The histological characteristics...
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Regions of the human renal artery: histomorphometric analysis

Mompeó-Corredera B, Hernández-Morera P, Castaño-González I, Quintana-Montesdeoca MdP, Mederos-Real N

The renal artery is frequently involved in the pathogenesis of vasculorenal diseases, and it is a target in kidney surgery and therapeutic techniques for refractory hypertension. However, few detailed structural...
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