Int J Oral Biol.  2018 Sep;43(3):133-140. 10.11620/IJOB.2018.43.3.133.

Effect of Resveratrol on Cell Differentiation and Mineralization in Cultured Odontoblasts

Affiliations
  • 1Oral Biology Research Institute, School of Dentistry, Chosun University, Gwangju 61452, Republic of Korea. kdk@chosun.ac.kr
  • 2Department of Oral Histology-Developmental Biology and Dental Research Institute, School of Dentistry, Seoul National University, 101 Daehagro, Chongro-gu, Seoul 03080, Republic of Korea.

Abstract

Resveratrol (3,4"²,5,-trihydroxystilbene), a phytoalexin present in grapes, exerts a variety of actions to reduce superoxides, prevents diabetes mellitus, and inhibits inflammation. Resveratrol acts as a chemo-preventive agent and induces apoptotic cell death in various cancer cells. However, the role of resveratrol in odontoblastic cell differentiation is unclear. In this study, the effect of resveratrol on regulating odontoblast differentiation was examined in MDPC-23 mouse odontoblastic cells derived from mouse dental papilla cells. Resveratrol significantly accelerated mineralization as compared with the control culture in differentiation of MDPC-23 cells. Resveratrol significantly increased expression of ALP mRNA as compared with the control in differentiation of MDPC-23 cells. Resveratrol significantly accelerated expression of ColImRNA as compared with the control in differentiation of MDPC-23 cells. Resveratrol significantly increased expressions of DSPP and DMP-1 mRNAs as compared with the control in differentiation of MDPC-23 cells. Treatment of resveratrol did not significantly affect cell proliferation in MDPC-23 cells. Results suggest resveratrol facilitates odontoblast differentiation and mineralization in differentiation of MDPC-23 cells, and may have potential properties for development and clinical application of dentin regeneration materials.

Keyword

resveratrol; odontoblasts; differentiation; mineralization

MeSH Terms

Animals
Cell Death
Cell Differentiation*
Cell Proliferation
Dental Papilla
Dentin
Diabetes Mellitus
Inflammation
Mice
Miners*
Odontoblasts*
Regeneration
RNA, Messenger
Superoxides
Vitis
RNA, Messenger
Superoxides
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