Epidemiol Health.  2011;33:e2011003.

ADIPOQ Gene Variants Associated with Susceptibility to Obesity and Low Serum Adiponectin Levels in Healthy Koreans

Affiliations
  • 1Department of Medical Genetics, College of Medicine, Hallym University, Chuncheon, Korea.
  • 2Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea.
  • 3Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea. jsunha@yuhs.ac
  • 4Metabolic Syndrome Research Initiatives, Seoul, Korea.

Abstract


OBJECTIVES
This study aimed to measure the association between the adiponectin, C1Q and collagen domain-containing (ADIPOQ) gene variants and obesity in Koreans.
METHODS
Three single nucleotide polymorphisms located in the ADIPOQ gene were genotyped in a population-based cross-sectional study of 986 healthy Koreans. Three different case-control groups (i.e. G1, G2, and G3) were defined according to body mass index (BMI) and serum adiponectin levels. Allelic and genotypic associations of this gene with obesity were measured using multivariate logistic regression analyses in each group.
RESULTS
The G allele of -11377C>G, a polymorphism located in the promoter region of the ADIPOQ gene (odds ratio (OR), 1.48; 95% confidence interval, 1.13-1.94) and most haplotypes including this allele significantly increased the risk for obesity. However, the OR decreased from 3.98 (G1 group) to 2.90 (G2 group) and 2.30 (G3 group) when a less strict definition of obesity was used. Most haplotypes, including this allele, significantly increased the risk of obesity. The statistical evidence from the GG genotype of -11377C>G (OR, 3.98) and the GT/GT diplotype composed of -11377G>C and +45T>G (OR, 5.20) confirmed the contribution of the G allele toward a predisposition for obesity.
CONCLUSION
These results suggest the contribution of the ADIPOQ gene toward susceptibility to obesity in healthy Koreans. The high-risk genotypes and haplotypes identified here may provide more information for identifying individuals who are at risk of obesity.

Keyword

Adiponectin; Single nucleotide polymorphism; Obesity; Body mass index

MeSH Terms

Adiponectin
Alleles
Body Mass Index
Case-Control Studies
Collagen
Cross-Sectional Studies
Genotype
Haplotypes
Logistic Models
Obesity
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Adiponectin
Collagen
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