Yonsei Med J.  2011 Jan;52(1):20-25. 10.3349/ymj.2011.52.1.20.

Association of the Adiponectin Gene Variations with Risk of Ischemic Stroke in a Korean Population

• Cheong MY
• Bang OS
• Cha MH
• Park YK
• Kim SH
• Kim YJ

• KMID: 1106432
• DOI: http://doi.org/10.3349/ymj.2011.52.1.20

Abstract

PURPOSE
Stroke is the second leading cause of death and a major cause of morbidity and mortality worldwide. Evidence of variations in adiponectin(AdipoQ) genes that are associated with ischemic stroke has not been consistent, and it is unclear whether the same loci contribute to these associations in the Korean population. Using a Korean population, we tested ischemic stroke-associated AdipoQ markers.
MATERIALS AND METHODS
In a preliminary genome-wide association study using 320 250 k Affymetrix NSP chips, AdipoQ was found to be associated with ischemic stroke in Koreans. To study of AdipoQ, a further 673 ischemic stroke patients and 267 unrelated individuals without a history of stroke or transient ischemic attack were examined in a case-control study.
RESULTS
Six polymorphisms (rs182052G > A, rs16861205G > A, rs822391T > C, rs822396A > G, rs12495941G > T and rs3774261A > G) that had a minor allele frequency of over 1% were strongly associated with stroke (p < 0.05). Two of these, rs822391T > C and rs822396A > G showed this association on both dominant and additive logistic regression analysis after adjusting for age and sex. The haplotypes ht 1 (AGGCGG and AAGTAG) were significantly associated with susceptibility to stroke.
CONCLUSION
Our findings show that polymorphisms in AdipoQ are associated with risk for ischemic stroke in the Korean population. This study lends further support to the putative role of AdipoQ in stroke.

Keyword

AdipoQ; ischemic; stroke; Koreans

MeSH Terms

Adiponectin/*genetics
Aged
Asian Continental Ancestry Group
Female
Genetic Predisposition to Disease/genetics
Haplotypes
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide/genetics
Stroke/epidemiology/*genetics

Figure

• 

  Fig. 1 Gene map and linkage disequilibrium blocks in the AdipoQ gene. (A) Map of AdipoQ gene on chromosome 3q27. (B) LD Blocks.

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