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Two-Sample Mendelian Randomization Study of Lipid levels and Ischemic Heart Disease

Lee SH, Lee JY, Kim Gh, Jung KJ, Lee S, Kim HC, Jee SH

Background and Objectives: Associations between blood lipids and risk of ischemic heart disease (IHD) have been reported in observational studies. However, due to confounding and reverse causation, observational studies are...
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Precision Medicine and Cardiovascular Health: Insights from Mendelian Randomization Analyses

Spiller W, Jung KJ, Lee JY, Jee SH

Cardiovascular disease (CVD) is considered a primary driver of global mortality and is estimated to be responsible for approximately 17.9 million deaths annually. Consequently, a substantial body of research related...
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Effects of Obesity and Family History of Diabetes on the Association of CETP rs6499861 with HDL-C Level in Korean Populations

Sull JW, Kim S, Jee SH

OBJECTIVES: The aim of this study was to examine the associations of cholesterol ester transfer protein (CETP) rs6499861 and rs12708980 with high-density lipoprotein cholesterol (HDL-C) considering obesity and family history...
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Bilirubin and risk of ischemic heart disease in Korea: a two-sample Mendelian randomization study

Jeon C, Lee JY, Lee SJ, Jung KJ, Kimm H, Jee SH

OBJECTIVES: Bilirubin is an endogenous antioxidant that protects cells against oxidative stress. Increased plasma levels of bilirubin have been associated with a reduced risk of ischemic heart disease (IHD) in...
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Low Dose Exposure to Di-2-Ethylhexylphthalate in Juvenile Rats Alters the Expression of Genes Related with Thyroid Hormone Regulation

Kim M, Jeong JS, Kim H, Hwang S, Park IH, Lee BC, Yoon SI, Jee SH, Nam KT, Lim KM

Phthalates widely used in the manufacture of plastics have deeply penetrated into our everyday lives. Recently, a concern over the toxicity of phthalates on thyroid, has been raised but in...
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Traditional and Genetic Risk Score and Stroke Risk Prediction in Korea

Jung KJ, Hwang S, Lee S, Kim HC, Jee SH

BACKGROUND AND OBJECTIVES: Whether using both traditional risk factors and genetic variants for stroke as opposed to using either of the 2 alone improves the prediction of stroke risk remains...
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The necessity of introducing plain packaging of tobacco products in Korea

Kim J, Lee S, Kimm H, Jee SH

Although the Korean government introduced a tobacco tax increase in 2015 and pictorial health warnings on tobacco packages in 2016, the smoking prevalence among Korean adult men has remained steady....
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Color Doppler Ultrasonography Is a Useful Tool for Diagnosis of Peripheral Artery Disease in Type 2 Diabetes Mellitus Patients with Ankle-Brachial Index 0.91 to 1.40

Hur KY, Jun JE, Choi YJ, Lee YH, Kim DJ, Park SW, Huh BW, Lee EJ, Jee SH, Huh KB, Choi SH

BACKGROUND: The clinical utility of ankle-brachial index (ABI) is not clear in subjects with less severe or calcified vessel. Therefore, we investigated the usefulness of color Doppler ultrasonography for diagnosing...
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ApoB/ApoA-I ratio is independently associated with carotid atherosclerosis in type 2 diabetes mellitus with well-controlled LDL cholesterol levels

Jun JE, Choi YJ, Lee YH, Kim DJ, Park SW, Huh BW, Lee EJ, Jee SH, Hur KY, Choi SH, Huh KB

BACKGROUND/AIMS: This study aimed to investigate whether the apolipoprotein (Apo) B/ApoA-I ratio is associated with carotid intima-media thickness (CIMT) in type 2 diabetes mellitus (T2DM) subjects with low density lipoprotein...
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The J-curve between Diastolic Blood Pressure and Risk of All-cause and Cardiovascular Death

Kimm H, Mok Y, Lee SJ, Lee S, Back JH, Jee SH

BACKGROUND AND OBJECTIVES: The J-curve phenomenon between diastolic blood pressure (DBP) and mortality has been reported repeatedly in treated patients. However, the baseline risk of low DBP has not been...
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Factors Affecting Quality of Life Among Spinal Cord Injury Patients in Korea

Lee JS, Kim SW, Jee SH, Kim JC, Choi JB, Cho SY, Kim JH, Korea Spinal Cord Injury Association

PURPOSE: Complaints from spinal cord injury (SCI) patients are typically related to physical disability affecting activities of daily life. However, difficulties with voiding and defecation and/or sexual function can also...
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The effect of smoking on lung cancer: ethnic differences and the smoking paradox

Jung KJ, Jeon C, Jee SH

The objectives of this review were to determine whether the smoking paradox still exists and to summarize possible explanations for the smoking paradox. Based on published data, we compared the...
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Impaired fasting glucose, single-nucleotide polymorphisms, and risk for colorectal cancer in Koreans

Jung KJ, Kim MT, Jee SH

OBJECTIVES: Numerous studies have demonstrated that fasting serum glucose (FSG) levels and certain single-nucleotide polymorphisms (SNPs) are related to an increased risk of colorectal cancer (CRC); however, their combined effects...
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Hypertriglyceridemia is a Major Factor Associated With Elevated Levels of Small Dense LDL Cholesterol in Patients With Metabolic Syndrome

Cho Y, Lee SG, Jee SH, Kim JH

BACKGROUND: We aimed to determine the major contributing component of metabolic syndrome (MetS) that results in an elevated small dense LDL cholesterol (sdLDL-C) concentration and sdLDL-C/LDL-C ratio. METHODS: Four hundred and...
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Risk Factors for Prolonged Carriage and Reacquisition of Vancomycin-resistant Enterococci

Lee D, Park ES, Yong D, Choi JY, Lee K, Jee SH

BACKGROUND: Patients infected with vancomycin-resistant enterococci (VRE) are kept in isolation to prevent the spread of VRE in medical facilities. However, decision-making regarding isolation can be challenging at the time...
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Consumption of Added Sugars and Lipid Profiles in Korean Population from a Cohort Study

Kim SY, Jee SH

OBJECTIVES: The purpose of the study was to examine the relationship between added sugar consumption and dyslipidemia. METHODS: Final study subjects consisted of 18,713 participants after the exclusion of participants with...
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Review on Cardiovascular Disease Prediction Model in Diabetes Patients

Jung KJ, Jee SH

The cardiovascular disease (CVD) risk prediction model has been developed based on information on CVD-free subjects, including age, hypertension, diabetes, cholesterol, and smoking status. A methodological review on whether the...
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The Korea National Suicide Survey (KNSS): Rationale and Design

Kim B, Jung KJ, Lee SU, Sea J, Kim EY, Kim SH, Jee SH, Park JI, Kim K, Ahn YM

Suicide, the fourth leading cause of death in Korea, is a serious national problem. The Korea National Suicide Survey (KNSS) is the result of the first legislation to address this...
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The ABCG2 Polymorphism rs2725220 Is Associated with Hyperuricemia in the Korean Population

Sull JW, Yang SJ, Kim S, Jee SH

Elevated serum uric acid levels are associated with a variety of adverse health outcomes, including gout, hypertension, diabetes mellitus, metabolic syndrome, and cardiovascular diseases. Several genome-wide association studies on uric...
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The Relationship Between Serum Lipids and Depression

Jung KJ, Mok Y, Chang HY, Son D, Han EJ, Yun YD, Jee SH

OBJECTIVE: Low cholesterol is associated with depression among western countries. The objective of this study was to examine the relationship between cholesterol and depression in Korean population with low levels...
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