Korean J Otorhinolaryngol-Head Neck Surg.  2017 Feb;60(2):49-54. 10.3342/kjorl-hns.2016.17230.

Oral Microbiome and Its Association with Oral Diseases

Affiliations
  • 1Department of Otorhinolaryngology, Eulji Medical Center, Eulji University, School of Medicine, Seoul, Korea. minsu014@gmail.com

Abstract

Microbiome means a holistic genomic information of microorganism which usually having symbiotic relationships confer benefits to human body. Breaches in the homeostasis between host and microorganism or alterations of the microbiome are well-known risk factors promoting human diseases. Oral cavity has hundreds of microbes and demonstrates chronic inflammatory conditions by interrelations among microorganisms, foreign bodies, alcohol, and smoking. Oral microbiome also demonstrates a growing evidence of its implication in the etiology of oral diseases including cancer and other systemic diseases. In this review paper, I would introduce to the associated human diseases with oral microbiome and the mechanism how changes in the oral microbiome with its microenvironment leads to the host diseases. And I would also suggest a new research field in otorhinolaryngology connected to oral microbiome.

Keyword

Cancer; Head and neck; Microbiome; Oral cavity; Oral mucositis
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