Lab Anim Res.  2016 Mar;32(1):46-55. 10.5625/lar.2016.32.1.46.

Reference values of hematology, biochemistry, and blood type in cynomolgus monkeys from cambodia origin

• Choi K
• Chang J
• Lee MJ
• Wang S
• In K
• Galano-tan WC
• Jun S
• Cho K
• Hwang YH
• Kim SJ
• Park W

• KMID: 2312153
• DOI: http://doi.org/10.5625/lar.2016.32.1.46

Abstract

Cynomolgus monkeys as nonhuman primates are valuable animal models because they have a high level of human gene homology. There are many reference values for hematology and biochemistry of Cynomolgus monkeys that are needed for proper clinical diagnosis and biomedical research conduct. The body weight information and blood type are also key success factors in allogeneic or xenogeneic models. Moreover, the biological parameters could be different according to the origin of the Cynomolgus monkey. However, there are limited references provided, especially of Cambodia origin. In this study, we measured average body weight of 2,518 Cynomolgus monkeys and analyzed hematology and serum biochemistry using 119 males, and determined blood types in 642 monkeys with Cambodia origin. The average body weight of male Cynomolgus monkeys were 2.56±0.345 kg and female group was 2.43±0.330 kg at the age from 2 to 3 years. The male group showed relatively sharp increased average body weight from the 3 to 4 age period compared to the female group. In hematology and biochemistry, it was found that most of the data was similar when compared to other references even though some results showed differences. The ABO blood type result showed that type A, B, AB, and O was approximately 15.6, 33.3, 44.2, and 6.9%, respectively. The main blood type in this facility was B and AB. These biological background references of Cambodia origin could be used to provide important information to researchers who are using them in their biomedical research.

Keyword

Cynomolgus monkey; cambodia origin; body weight; hematology; serum biochemistry; blood type

MeSH Terms

Biochemistry*
Body Weight
Cambodia*
Diagnosis
Female
Haplorhini
Hematology*
Humans
Macaca fascicularis*
Male
Models, Animal
Primates
Reference Values*

Figure

• 

  Figure 1 Average body weight of Cynomolgus monkeys. 588 male Cynomolgus monkeys (A) and 1,930 female Cynomolgus monkeys (B) were measured body weight by Orient Cam in Cambodia. Compare of average body weight between male (●) and female (○) Cynomolgus monkeys (C). All graphs were represented as mean±S.E.M.

• 

  Figure 2 Determination of blood type in Cynomolgus monkeys. Human RBC was mixed with serum of Cynomolgus monkey and observed the agglutination.

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