- XperCT-guided Intra-cisterna Magna Injection of Streptozotocin for Establishing an Alzheimer’s Disease Model Using the Cynomolgus Monkey (Macaca fascicularis)
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Park J, Won J, Jeon CY, Lim KS, Choi WS, Park Sh, Seo J, Cho J, Seong JB, Yeo HG, Kim K, Kim YG, Kim M, Yi KS, Lee Y
- KMID: 2537960
- Exp Neurobiol.
- 2022 Dec;31(6):409-418.
- doi: 10.5607/en22027
Till date, researchers have been developing animal models of Alzheimer’s disease (AD) in various species to understand the pathological characterization and molecular mechanistic pathways associated with this condition in humans... -
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- Claustral MeCP2 Regulates Methamphetamine-induced Conditioned Place Preference in Cynomolgus Monkey
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Bae J, Ahn S, Cho DW, Kim HS, Han SC, Im HI
- KMID: 2537958
- Exp Neurobiol.
- 2022 Dec;31(6):390-400.
- doi: 10.5607/en22034
The claustrum, a brain nucleus located between the cortex and the striatum, has recently been highlighted in drug-related reward processing. Methyl CpG-binding protein-2 (MeCP2) is a transcriptional regulator that represses... -
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- Surgical removal of a telemetry system in a cynomolgus monkey (Macaca fascicularis): a 12-month observation study
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Cho DW, Han HY, Yang MJ, Woo DH, Han SC, Yang YS
- KMID: 2523776
- Lab Anim Res.
- 2021 Dec;37(4):320-323.
- doi: 10.1186/s42826-021-00106-z
Background: Telemetry is a wireless implanted device that measures biological signals in conscious animals and usually requires surgery for its removal when the study is finished. After removing the device,... -
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- A comparative study on intraocular pressure under various anesthetics in cynomolgus monkeys (Macaca fascicularis)
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Lee HS, Kim DH, Kim SH, Kang MS, Suh HN
- KMID: 2517256
- Lab Anim Res.
- 2021 Jun;37(2):112-115.
- doi: 10.1186/s42826-021-00092-2
Background: Nonhuman primates (NHPs) are superior model for ocular research due to its morphological and physiological similarities with humans. Thus, the effect of four different anesthetic combinations [ketamine (10 mg/... -
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- Generation of cynomolgus monkey fetuses with intracytoplasmic sperm injection based on the MII-stage oocytes acquired by personalized superovulation protocol
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Huang Z, Li Y, Jiang Q, Wang Y, Ma K, Li Q
- KMID: 2502378
- J Vet Sci.
- 2020 May;21(3):e48.
- doi: 10.4142/jvs.2020.21.e48
Background: Mature oocytes at the metaphase II status (MII-stage oocytes) played an important role in assisted reproductive technology in non-human primates. Objectives: In order to improve the proportion of MII-stage oocytes... -
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- Reference values of hematological and biochemical parameters in young-adult cynomolgus monkey (Macaca fascicularis) and rhesus monkey (Macaca mulatta) anesthetized with ketamine hydrochloride
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Koo BS, Lee DH, Kang P, Jeong KJ, Lee S, Kim K, Lee Y, Huh JW, Kim YH, Park SJ, Jin YB, Kim SU, Kim JS, Son Y, Lee SR
- KMID: 2470106
- Lab Anim Res.
- 2019 Aug;35(2):39-44.
- doi: 10.1186/s42826-019-0006-0
Nonhuman primate models are valuable in biomedical research. However, reference data for clinical pathology parameters in cynomolgus and rhesus monkeys are limited. In the present study, we established hematologic and... -
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- Evaluation of fecal microbiomes associated with obesity in captive cynomolgus monkeys (Macaca fascicularis)
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Koo BS, Hwang EH, Kim G, Oh H, Son Y, Lee D, Lim KS, Kang P, Lee S, Lee HY, Jeong KJ, Lee Y, Baek SH, Jeon CY, Park SJ, Kim YH, Huh JW, Jin YB, Kim SU, Lee SR, Hong JJ
- KMID: 2448703
- J Vet Sci.
- 2019 May;20(3):e19.
- doi: 10.4142/jvs.2019.20.e19
Microorganisms play important roles in obesity; however, the role of the gut microbiomes in obesity is controversial because of the inconsistent findings. This study investigated the gut microbiome communities in... -
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- Reference values of clinical pathology parameters in cynomolgus monkeys (Macaca fascicularis) used in preclinical studies
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Park HK, Cho JW, Lee BS, Park H, Han JS, Yang MJ, Im WJ, Park DY, Kim WJ, Han SC, Kim YB
- KMID: 2309080
- Lab Anim Res.
- 2016 Jun;32(2):79-86.
- doi: 10.5625/lar.2016.32.2.79
Nonhuman primates are increasingly used in biomedical research since they are highly homologous to humans compared to other rodent animals. However, there is limited reliable reference data of the clinical... -
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- Reference values of hematology, biochemistry, and blood type in cynomolgus monkeys from cambodia origin
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Choi K, Chang J, Lee MJ, Wang S, In K, Galano-tan WC, Jun S, Cho K, Hwang YH, Kim SJ, Park W
- KMID: 2312153
- Lab Anim Res.
- 2016 Mar;32(1):46-55.
- doi: 10.5625/lar.2016.32.1.46
Cynomolgus monkeys as nonhuman primates are valuable animal models because they have a high level of human gene homology. There are many reference values for hematology and biochemistry of Cynomolgus... -
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- No expression of porcine endogenous retrovirus after pig to monkey xenotransplantation
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Hwang S, Jung YD, Cho K, Ock SA, Oh KB, Kim HS, Yun IJ, Ahn C, Park JK, Im S
- KMID: 1707449
- Lab Anim Res.
- 2014 Jun;30(2):90-93.
- doi: 10.5625/lar.2014.30.2.90
This study was performed to investigate the expression of two porcine endogenous retrovirus (PERV) elements, PERV gag and full-length conserved PERV, in blood cells collected periodically from organ-recipient monkeys that... -
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- Milk Transfer and Toxicokinetics of Valproic Acid in Lactating Cynomolgus Monkeys
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Lee JH, Yu WJ, Jeong EJ, Chung MK
- KMID: 2317816
- Toxicol Res.
- 2013 Mar;29(1):53-60.
Studies on milk transfer of drugs in non-human primates (NHPs) are among the crucial components in the assessment of peri- and postnatal toxicity because of the similarity between NHPs and... -
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- Rectal Prolapse Associated with Recurrent Diarrhea in a Laboratory Cynomolgus Monkey (Macaca fascicularis)
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Lee SR, Lee YH, Kim KM, Kim SW, Jung KJ, Kim YH, Son HY, Chang KT
- KMID: 2114713
- Lab Anim Res.
- 2010 Dec;26(4):429-432.
- doi: 10.5625/lar.2010.26.4.429
Rectal prolapse is a protrusion of one or more layers of the rectum through the anus. A 5-year-old laboratory cynomolgus monkey who had suffered from recurrent diarrhea died after surgical... -
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- Experimental autoimmune encephalomyelitis in cynomolgus monkeys
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Nam KH
- KMID: 1094651
- J Vet Sci.
- 2000 Dec;1(2):127-131.
Experimental autoimmune encephalomyelitis was induced in macaques. T cell clones infiltrated into the brain lesion area were compared with those in blood. Intradermal immunization of macaques with brain white matter... -
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