- An Alternative Dendritic Cell-Induced Murine Model of Asthma Exhibiting a Robust Th2/Th17-Skewed Response
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Park SC, Kim H, Bak Y, Shim D, Kwon KW, Kim CH, Yoon JH, Shin SJ
- KMID: 2471235
- Allergy Asthma Immunol Res.
- 2020 May;12(3):537-555.
- doi: 10.4168/aair.2020.12.3.537
PURPOSE: Simple and reliable animal models of human diseases contribute to the understanding of disease pathogenesis as well as the development of therapeutic interventions. Although several murine models to mimic... -
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- Therapeutic Effect of a Novel Chimeric Molecule Targeting Both Somatostatin and Dopamine Receptors on Growth Hormone-Secreting Pituitary Adenomas
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Kim J, Oh JH, Harlem H, Culler MD, Ku CR, Lee EJ
- KMID: 2471734
- Endocrinol Metab.
- 2020 Mar;35(1):177-187.
- doi: 10.3803/EnM.2020.35.1.177
BACKGROUND: Acromegaly is a rare disease primarily caused by growth hormone (GH)-secreting pituitary adenomas, and its treatment is costly. Moreover, some patients are unresponsive to treatment. Hence, there are increasing... -
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- Epithelial PI3K-δ Promotes House Dust Mite-Induced Allergic Asthma in NLRP3 Inflammasome-Dependent and -Independent Manners
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Kim SR, Park HJ, Lee KB, Kim HJ, Jeong JS, Cho SH, Lee YC
- KMID: 2468466
- Allergy Asthma Immunol Res.
- 2020 Mar;12(2):338-358.
- doi: 10.4168/aair.2020.12.2.338
PURPOSE: Phosphoinositide 3-kinase (PI3K)-δ-dependent Akt activation is known to play critical roles in various immune responses of white blood cells in which PI3K-δ isoform is mostly expressed in contrast to... -
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- Evaluation of Neo-Osteogenesis in Eosinophilic Chronic Rhinosinusitis Using a Nasal Polyp Murine Model
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Khalmuratova R, Lee M, Park JW, Shin HW
- KMID: 2468464
- Allergy Asthma Immunol Res.
- 2020 Mar;12(2):306-321.
- doi: 10.4168/aair.2020.12.2.306
PURPOSE: Osteitis refers to the development of new bone formation and remodeling of bone in chronic rhinosinusitis (CRS) patients; it is typically associated with eosinophilia, nasal polyps (NPs), and recalcitrant... -
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- Role of MicroRNA-34a in Anti-Apoptotic Effects of Granulocyte-Colony Stimulating Factor in Diabetic Cardiomyopathy
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Park IH, Song YS, Joo HW, Shen GY, Seong JH, Shin NK, Cho YJ, Lee Y, Shin JH, Lim YH, Kim H, Kim KS
- KMID: 2470965
- Diabetes Metab J.
- 2020 Feb;44(1):173-185.
- doi: 10.4093/dmj.2018.0211
BACKGROUND: Recent studies have shown that microRNAs (miRNAs) are involved in the process of cardiomyocyte apoptosis. We have previously reported that granulocyte-colony stimulating factor (G-CSF) ameliorated diastolic dysfunction and attenuated... -
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- Cystic fibrosis lung disease: Current perspectives
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Jung JA
- KMID: 2469112
- Allergy Asthma Respir Dis.
- 2020 Jan;8(1):3-8.
- doi: 10.4168/aard.2020.8.1.3
Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR). These mutations alter the synthesis, processing, function, or... -
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- Derivation of endothelial cells from porcine induced pluripotent stem cells by optimized single layer culture system
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Wei R, Lv J, Li X, Li Y, Xu Q, Jin J, Zhang Y, Liu Z
- KMID: 2469024
- J Vet Sci.
- 2020 Jan;21(1):e9.
- doi: 10.4142/jvs.2020.21.e9
Regenerative therapy holds great promise in the development of cures of some untreatable diseases such as cardiovascular diseases, and pluripotent stem cells (PSCs) including induced PSCs (iPSCs) are the most... -
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- The effect of cetirizine, a histamine 1 receptor antagonist, on bone remodeling after calvarial suture expansion
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Hwang S, Chung CJ, Choi YJ, Kim T, Kim KH
- KMID: 2468640
- Korean J Orthod.
- 2020 Jan;50(1):42-51.
- doi: 10.4041/kjod.2020.50.1.42
OBJECTIVE: The objective of this study was to evaluate the effects of cetirizine, a histamine 1 receptor antagonist, on bone remodeling after calvarial suture expansion. METHODS: Sixty male Sprague–Dawley rats were... -
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- Animal model evaluation of a novel renal denervation system for future laparoscopic treatment of resistant hypertension
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Song WH, Baik J, Yang S, Choi EK, Park SM, Jeong CW
- KMID: 2466799
- Investig Clin Urol.
- 2020 Jan;61(1):107-113.
- doi: 10.4111/icu.2020.61.1.107
PURPOSE: Although percutaneous catheter-based ablation of renal sympathetic nerve fibers has been used in the treatment of patients with resistant hypertension, a recent phase III study did not confirm its... -
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- Effects of tranilast on the epithelial-to-mesenchymal transition in peritoneal mesothelial cells
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Kang SH, Kim SW, Kim KJ, Cho KH, Park JW, Kim CD, Do JY
- KMID: 2469377
- Kidney Res Clin Pract.
- 2019 Dec;38(4):472-480.
- doi: 10.23876/j.krcp.19.049
BACKGROUND: We investigated the effects of tranilast on epithelial-to-mesenchymal transition (EMT) in an animal model and on the EMT signaling pathway in human peritoneal mesothelial cells (HPMCs). METHODS: We performed in... -
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- Recapitulation of Neuropsychiatric Behavioral Features in Mice Using Acute Low-dose MK-801 Administration
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Mabunga DF, Park D, Ryu O, Valencia S, Adil KJ, Kim S, Kwon KJ, Shin CY, Jeon SJ
- KMID: 2468886
- Exp Neurobiol.
- 2019 Dec;28(6):697-708.
- doi: 10.5607/en.2019.28.6.697
Despite some innate limitations, animal models are a potent investigative tool when used to model specific symptoms of a disorder. For example, MK-801, an N-methyl-D-aspartate receptor antagonist, is used as... -
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- Anti-arthritic Effects of Oplopanax elatus in a Rat Model of Rheumatoid Arthritis (Adjuvant-induced Arthritis)
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Kwon KS, Lim H, Kwon YS, Choi HR, Kim MJ, Yoo JH, Yoo NH, Kim HP
- KMID: 2468063
- Nat Prod Sci.
- 2019 Dec;25(4):304-310.
- doi: 10.20307/nps.2019.25.4.304
The stems of Oplopanax elatus (OE) have long been used to treat inflammatory disorders in herbal medicine, and in the previous investigation, OE was found to possess anti-inflammatory activity in... -
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- Bladder Augmentation Using Lyoplant® : First Experimental Results in Rats
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Winde F, Backhaus K, Zeitler JA, Schlegel N, Meyer T
- KMID: 2467056
- Tissue Eng Regen Med.
- 2019 Dec;16(6):645-652.
- doi: 10.1007/s13770-019-00209-8
BACKGROUND: Congenital defects of the urinary bladder (micro- or contracted bladder, bladder exstrophy) remain a challenging problem for pediatric surgeons. Even when conservative treatment options are fully exhausted, irreversible renal... -
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- Splenocyte-mediated immune enhancing activity of Sargassum horneri extracts
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Kim DS, Sung NY, Han IJ, Lee BS, Park SY, Nho EY, Eom J, Kim G, Kim KA
- KMID: 2466666
- J Nutr Health.
- 2019 Dec;52(6):515-528.
- doi: 10.4163/jnh.2019.52.6.515
PURPOSE: This study examined the immunological activity and optimized the mixture conditions of Sargassum horneri (S. horneri) extracts in vitro and in vivo models. METHODS: S. horneri was extracted using three... -
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- Two Faces of White Adipose Tissue with Heterogeneous Adipogenic Progenitors
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Hwang I, Kim JB
- KMID: 2466496
- Diabetes Metab J.
- 2019 Dec;43(6):752-762.
- doi: 10.4093/dmj.2019.0174
Chronic energy surplus increases body fat, leading to obesity. Since obesity is closely associated with most metabolic complications, pathophysiological roles of adipose tissue in obesity have been intensively studied. White... -
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- Electroretinography Changes in Feline Model of Iodoacetic Acid-induced Retinal Degeneration
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Kim C, Lee M, Lee SU, Lee SJ
- KMID: 2466172
- J Korean Ophthalmol Soc.
- 2019 Dec;60(12):1205-1215.
- doi: 10.3341/jkos.2019.60.12.1205
PURPOSE: We explored changes in photoreceptor function and histology in an iodoacetic acid (IAA)-induced model of feline retinal degeneration. METHODS: From January to October 2014, we studied 11 adult felines (22... -
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- Berberine Ameliorates Brain Inflammation in Poloxamer 407-Induced Hyperlipidemic Rats
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Kim M, Kim TW, Kim CJ, Shin MS, Hong M, Park HS, Park SS
- KMID: 2467318
- Int Neurourol J.
- 2019 Nov;23(Suppl 2):S102-S110.
- doi: 10.5213/inj.1938216.108
PURPOSE: Hyperlipidemia, which promotes the development of atherosclerosis, ischemic stroke, and other forms of brain injury, can be induced by poloxamer-407. Berberine is a primary pharmacological active component of Coptidis... -
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- Adult Stem Cells in Hibernation: Future Perspectives of Space Travel
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Chen YC, Aui SP, Lai YS, Chang KT
- KMID: 2465878
- Int J Stem Cells.
- 2019 Nov;12(3):381-387.
- doi: 10.15283/ijsc19048
Space traveling is imperative for mankind in the future. Expectedly, hibernation will become an option for space traveler to overcome the endless voyage. With regard to some of the studies... -
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- Development of an acute pancreatitis porcine model based on endoscopic retrograde infusion of contrast medium or sodium taurocholate
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Park JS, Jeong S, Kim JM, Lee BH, Kim JM, Lee DH
- KMID: 2463482
- Korean J Intern Med.
- 2019 Nov;34(6):1244-1251.
- doi: 10.3904/kjim.2017.367
BACKGROUND/AIMS: A reproducible, endoscope-based, large animal model, of acute pancreatitis was developed to meet the need for a suitable means of preclinically testing treatments. The aim of this study was... -
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- Influence of clozapine on neurodevelopmental protein expression and behavioral patterns in animal model of psychiatric disorder induced by low-level of lead
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Lee H, Lee M, Kim HK, Kim YO, Kwon JT, Kim HJ
- KMID: 2461039
- Korean J Physiol Pharmacol.
- 2019 Nov;23(6):467-474.
- doi: 10.4196/kjpp.2019.23.6.467
Exposure to lead during pregnancy is a risk factor for the development of psychiatric disorders in the offspring. In this study, we investigated whether exposure to low levels of lead... -
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