Korean Diabetes J.  2009 Dec;33(6):485-493. 10.4093/kdj.2009.33.6.485.

The Relationship Between Coronary Artery Calcification and Serum Apolipoprotein A-1 in Patients with Type 2 Diabetes

Affiliations
  • 1Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea. jugkim@knu.ac.kr

Abstract

BACKGROUND
The incidence of type 2 diabetes mellitus is increasing annually and patient mortality is high. Coronary artery calcification is a predictor of coronary artery disease. Cardiovascular events, which are the main cause of death in type 2 diabetes patients, may be preventable by addressing risk factors associated with coronary artery calcification. We examined the relationships between coronary artery calcification, lipid profiles, and apolipoprotein levels. METHODS: We calculated the coronary calcium scores (CCS) of 254 subjects with type 2 diabetes (113 males, 141 females) via multi-detector row computed tomography (MDCT). Height, body weight, blood pressure, HbA1c, c-peptide, lipid profile and apolipoprotein were assessed concurrently. RESULTS: In patients with type 2 diabetes, Agatston score and apolipoprotein A-1 were significantly negatively correlated in both males and females (males P = 0.015, females P = 0.021). The negative correlation between Agatston score and apolipoprotein A-1 was retained for the entire patient sample after adjustments for age and sex (P = 0.022). Stepwise multiple regression anaylses with the Agatston score as the dependent variable indicate that apolipoprotein A-1 is a independent predictor (beta coefficient = -0.047, 95%CI = -0.072 ~ -0.021, P < 0.001) of coronary artery calcification. CONCLUSION: The results of our study suggest that apolipoprotein A-1 is a useful independent indicator of coronary artery calcification.

Keyword

Apolipoproteins; Atherosclerosis; Cardiovascular diseases; Lipids; Type 2 diabetes mellitus

MeSH Terms

Apolipoprotein A-I
Apolipoproteins
Atherosclerosis
Blood Pressure
Body Height
C-Peptide
Calcium
Cardiovascular Diseases
Cause of Death
Coronary Artery Disease
Coronary Vessels
Diabetes Mellitus, Type 2
Female
Humans
Incidence
Male
Risk Factors
Apolipoprotein A-I
Apolipoproteins
C-Peptide
Calcium

Figure

  • Fig. 1 Negative correlation was seen between Ln (Agatston + 1) and serum apolipoprotein A-1 in females (LnAgatston = Ln (Agatston + 1)).

  • Fig. 2 Negative correlation was seen between Ln (Agatston + 1) and serum apolipoprotein A-1 in males (LnAgatston = Ln (Agatston + 1)).


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