Korean J Med.  2010 Aug;79(2):163-170.

Association of serum osteoprotegerin with coronary artery calcification scores in patients with asymptomatic type 2 diabetes

• Cho EH
• Lee DG
• Kim SW

Abstract

BACKGROUND/AIMS
Osteoprotegerin (OPG), a member of the tumor necrosis factor (TNF) receptor superfamily, is involved in bone metabolism and vascular calcification. However, the relationship between serum OPG levels and coronary calcification is not well elucidated. The present study investigated whether serum OPG levels are associated with coronary artery calcification scores (CACs) in patients with type 2 diabetes.
METHODS
A total of 140 type 2 diabetic outpatients without previous evidence of clinical cardiovascular disease were recruited. CACs were obtained using multi-slice spiral computed tomography and categorized as minimal (0), mild (1-99), moderate (100-399), or severe (> or = 400). Serum OPG levels were measured by enzyme-linked immunosorbent assay.
RESULTS
A total of 94 of 140 (67.1%) patients with type 2 diabetes showed coronary calcification. A Pearson's correlation analysis showed a positive correlation between serum OPG levels and CACs. However, multivariate regression analyses revealed that waist circumference, duration of diabetes, and serum creatinine concentration were significant independent determinants of CACs.
CONCLUSIONS
The present study demonstrates that coronary calcification is common (67.1%), and serum OPG levels are correlated with CACs but are not an independent determinant of CACs in patients with asymptomatic type 2 diabetes.

Keyword

Osteoprotegerin; Coronary artery; Calcification; Diabetes mellitus

MeSH Terms

Cardiovascular Diseases
Coronary Vessels
Creatinine
Diabetes Mellitus
Enzyme-Linked Immunosorbent Assay
Humans
Osteoprotegerin
Outpatients
Tomography, Spiral Computed
Tumor Necrosis Factor-alpha
Vascular Calcification
Waist Circumference
Creatinine
Osteoprotegerin
Tumor Necrosis Factor-alpha