J Korean Acad Fam Med.  2008 Mar;29(3):189-194.

Relationship between Insulin Resistance and Circulating Levels of Monocyte Chemoattractant Protein?1 in Healthy Adults

• Yoon JH
• Choi HJ
• Yoon KS
• Kim SH

Abstract

BACKGROUND: Insulin resistance is one of the underlying causes for atherosclerosis. The monocyte chemoattractant protein-1 (MCP-1) plays a crucial role in initiating atherogenesis by recruiting monocytes/macrophages to vessel wall. In this study, we investigated the relationship between homeostasis model assessment-estimated insulin resistance (HOMA-IR) and circulating level of MCP-1 in healthy adults.
METHODS
By reviewing the medical records of 171 healthy adults, we determined the circulating level of MCP-1, body mass index, systolic blood pressure, diastolic blood pressure, triglycerides, total cholesterol, LDL- cholesterol, HDL-cholesterol, fasting glucose, fasting insulin level and HOMA-IR. We studied the relationship between the variables by Pearson correlation coefficients and multiple linear regression analysis.
RESULTS
MCP-1 correlated positively with HOMA-IR (r=0.28; P<0.01). Age, systolic blood pressure, diastolic blood pressure, triglycerides, LDL-cholesterol, fasting glucose and insulin level also showed stastically significant correlation. Age, gender, HOMA-IR were the variables which affected MCP-1 by multiple regression analysis adjusting for body mass index, systolic blood pressure, triglycerides, and LDL-cholesterol.
CONCLUSION
In our study, circulating levels of MCP-1 were associated with insulin resistance. These findings support the potential role of MCP-1 as a biomarker for subclinical atherosclerosis.

Keyword

MCP-1; insulin resistance; HOMA-IR; atherosclerosis

MeSH Terms

Adult
Atherosclerosis
Blood Pressure
Body Mass Index
Chemokine CCL2
Cholesterol
Fasting
Glucose
Glycosaminoglycans
Homeostasis
Humans
Insulin
Insulin Resistance
Linear Models
Medical Records
Monocytes
Triglycerides
Chemokine CCL2
Cholesterol
Glucose
Glycosaminoglycans
Insulin
Triglycerides