Korean J Otorhinolaryngol-Head Neck Surg.  2013 Jun;56(6):327-331. 10.3342/kjorl-hns.2013.56.6.327.

Tissue Remodeling in Rhinosinusitis

Affiliations
  • 1Department of Otorhinolaryngology-Head and Neck Surgery, Division of Biomedical Sciences, Institute for Medical Devices Clinical Trial Center, Korea University College of Medicine, Seoul, Korea. lhman@korea.ac.kr

Abstract

Chronic rhinosinusitis is characterized by chronic inflammation of the nasal and paranasal mucosae and is currently classified into two major subgroups on the basis of the absence or presence of nasal polyps. A distinct set of inflammatory and remodeling factors has been found elevated in chronic rhinosinusitis. Transforming growth factor-beta and matrix metalloproteinases are critical factors involved in the remodeling process. Transforming growth factor-beta has been implicated as an important factor in remodeling processes involved in chronic rhinosinusitis, and serves as a main switch for different remodeling patterns in chronic rhinosinusitis.

Keyword

Chronic rhinosinusitis; Extracellular matrix; Matrix metalloproteinase; Remodeling; Transforming growth factor-beta
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