- All-Trans Retinoic Acid Has a Potential Therapeutic Role for Diabetic Nephropathy
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Kim CS, Park JS, Ahn CW, Kim KR
- KMID: 2345888
- Yonsei Med J.
- 2015 Nov;56(6):1597-1603.
- doi: 10.3349/ymj.2015.56.6.1597
PURPOSE: The aim of this study was to examine the effects of all-trans retinoic acid (ATRA) on diabetic nephropathy. MATERIALS AND METHODS: We measured amounts of urinary albumin excretion (UAE) after... -
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- Thalidomide Accelerates the Degradation of Extracellular Matrix in Rat Hepatic Cirrhosis via Down-Regulation of Transforming Growth Factor-beta1
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Lv P, Meng Q, Liu J, Wang C
- KMID: 2345885
- Yonsei Med J.
- 2015 Nov;56(6):1572-1581.
- doi: 10.3349/ymj.2015.56.6.1572
PURPOSE: The degradation of the extracellular matrix has been shown to play an important role in the treatment of hepatic cirrhosis. In this study, the effect of thalidomide on the... -
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- Effect of Cysteamine on Human Peripheral Blood Mononuclear Cells-Chemically Injured Keratocytes Reaction
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Lee YB, Hyon JY, Wee WR, Chung TY, Chung ES, Yi KY, Shin YJ
- KMID: 2214409
- J Korean Ophthalmol Soc.
- 2015 Oct;56(10):1511-1519.
- doi: 10.3341/jkos.2015.56.10.1511
PURPOSE: To investigate the effect of cysteamine on mixed peripheral blood mononuclear cells (PBMCs)-chemically injured keratocytes reaction (mixed lymphocyte-keratocyte reaction; MLKR). METHODS: PBMC stimulation assay was performed after keratocytes were chemically... -
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- Differences in Hypertrophic Scar Fibroblasts according to Scar Severity: Expression of Transforming Growth Factor beta1 at the mRNA and Protein Levels
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Kim SY, Nam SM, Park ES, Kim YB
- KMID: 2117978
- Arch Aesthetic Plast Surg.
- 2015 Oct;21(3):116-120.
- doi: 10.14730/aaps.2015.21.3.116
BACKGROUND: Hypertrophic scars result from excessive collagen deposition and increased transforming growth factor beta-1 (TGF-beta1) levels. We hypothesized that the expression of TGF-beta1 mRNA and protein would increase with the... -
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- Transforming growth factor-beta receptor 2 gene polymorphisms are associated with end-stage renal disease
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Ki HJ, Kim SY, Lee SH, Moon JY, Jeong KH, Lee TW, Ihm CG, Kim SK, Chung JH, Kang SW, Kim TH, Kim YH, Kim YG
- KMID: 2381523
- Kidney Res Clin Pract.
- 2015 Jun;34(2):93-97.
- doi: 10.1016/j.krcp.2015.05.002
BACKGROUND: Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine involved in immune disorders, cancer, asthma, lung fibrosis, and chronic kidney disease, and its signal pathways are considered crucial mediators of... -
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- Expression Patterns of Gli-1, Pleckstrin Homology-Like Domain, Family A, Member 1, Transforming Growth Factor-beta1/beta2, and p63 in Sebaceous and Follicular Tumors
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Jeon SY, Kim DC, Song KH, Kim KH
- KMID: 2264866
- Ann Dermatol.
- 2014 Dec;26(6):713-721.
- doi: 10.5021/ad.2014.26.6.713
BACKGROUND: Certain epidermal appendage tumors, including hyperplasias (hamartomas), adenomas, benign epitheliomas, primordial epitheliomas, and malignant tumors, can exhibit any stage of differentiation. Several molecules associated with tumorigenesis, such as Gli-1,... -
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- Targeting the Transforming Growth Factor-beta Signaling in Cancer Therapy
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Sheen YY, Kim MJ, Park SA, Park SY, Nam JS
- KMID: 2048301
- Biomol Ther.
- 2013 Sep;21(5):323-331.
TGF-beta pathway is being extensively evaluated as a potential therapeutic target. The transforming growth factor-beta (TGF-beta) signaling pathway has the dual role in both tumor suppression and tumor promotion. To... -
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- Effects of Xanthium stramarium and Psoralea corylifolia Extracts Combined with UVA1 Irradiation on the Cell Proliferation and TGF-beta1 Expression of Keloid Fibroblasts
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Park SY, Park JY, Kim CH, Kang SU, Kim JH, Bark KM, Kim TH, Shin SC, Kang HY
- KMID: 2265869
- Ann Dermatol.
- 2013 Aug;25(3):304-309.
- doi: 10.5021/ad.2013.25.3.304
BACKGROUND: Xanthium stramarium (XAS) and Psoralea corylifolia (PSC), phototoxic oriental medicinal plants, has been used in traditional medicines in Asian countries. OBJECTIVE: The effects of highly purified XAS or PSC extract... -
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- Tissue Remodeling in Rhinosinusitis
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Lee HM
- KMID: 2277765
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2013 Jun;56(6):327-331.
- doi: 10.3342/kjorl-hns.2013.56.6.327
Chronic rhinosinusitis is characterized by chronic inflammation of the nasal and paranasal mucosae and is currently classified into two major subgroups on the basis of the absence or presence of... -
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- Neurovascular Manifestation of Loeys-Dietz Syndrome: A Case Report
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Lee YJ, Yum MS, Kim EH, Choi HW, Lee BH, Yoo HW, Ko TS
- KMID: 2055579
- J Genet Med.
- 2013 Jun;10(1):47-51.
- doi: 10.5734/JGM.2013.10.1.47
Loeys-Dietz syndrome (LDS) is an autosomal dominant disorder caused by heterozygous mutations in the genes encoding transforming growth factor-beta receptor type 1 or 2. It is typically characterized by a... -
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- Bedside-Friendly Prediction for Presence of Post-Myocardial lnfarction Systolic Dysfunction Using Multimarker Panel: Integrating Salivary Diagnostics into Clinical Practice
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Assareh A, Haybar H, Yoosefi H, Bozorgmanesh M
- KMID: 2224947
- Korean Circ J.
- 2013 Apr;43(4):246-254.
- doi: 10.4070/kcj.2013.43.4.246
BACKGROUND AND OBJECTIVES: We investigated if a combination of plasma or salivary interleukin-2 (IL-2), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), transforming growth factor-beta (TGF-beta), and troponin can improve estimation of... -
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- Expression of peroxisome proliferator-activated receptor (PPAR)-alpha and PPAR-gamma in the lung tissue of obese mice and the effect of rosiglitazone on proinflammatory cytokine expressions in the lung tissue
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Ryu SL, Shim JW, Kim DS, Jung HL, Park MS, Park SH, Lee J, Lee WY, Shim JY
- KMID: 1427931
- Korean J Pediatr.
- 2013 Apr;56(4):151-158.
- doi: 10.3345/kjp.2013.56.4.151
PURPOSE: We investigated the mRNA levels of peroxisome proliferator-activated receptor (PPAR)-alpha, PPAR-gamma, adipokines, and cytokines in the lung tissue of lean and obese mice with and without ovalbumin (OVA) challenge,... -
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- Rapamycin Inhibits Transforming Growth Factor beta1-Induced Fibrogenesis in Primary Human Lung Fibroblasts
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Gao Y, Xu X, Ding K, Liang Y, Jiang D, Dai H
- KMID: 1503908
- Yonsei Med J.
- 2013 Mar;54(2):437-444.
- doi: 10.3349/ymj.2013.54.2.437
PURPOSE: The present study was designed to determine whether rapamycin could inhibit transforming growth factor beta1 (TGF-beta1)-induced fibrogenesis in primary lung fibroblasts, and whether the effect of inhibition would occur... -
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- Impact of gene polymorphisms of interleukin-18, transforming growth factor-beta, and vascular endothelial growth factor on development of IgA nephropathy and thin glomerular basement membrane disease
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Jung HY, Cho JH, Lim JH, Yu CH, Choi JY, Yoon SH, Park SH, Kim YL, Kim CD
- KMID: 1426334
- Kidney Res Clin Pract.
- 2012 Dec;31(4):234-241.
BACKGROUND: We investigated the effects of gene polymorphisms on the development of IgA nephropathy and thin glomerular basement membrane (GBM) disease by analyzing polymorphisms in the interleukin (IL)-18, transforming growth... -
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- TGF-beta-activated kinase-1: New insights into the mechanism of TGF-beta signaling and kidney disease
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Kim SI, Choi ME
- KMID: 1441574
- Kidney Res Clin Pract.
- 2012 Jun;31(2):94-105.
Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates a wide variety of cellular functions, including cell growth, cellular differentiation, apoptosis, and wound healing. TGF-beta1, the prototype member of... -
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- A Case of Near Total Aortic Replacement in an Adolescent With Loeys-Dietz Syndrome
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Suh YJ, Kwon HW, Kim GB, Kwon BS, Bae EJ, Noh CI, Choi JY, Kim KH, Kim YJ, Park SS
- KMID: 2225025
- Korean Circ J.
- 2012 Apr;42(4):288-291.
- doi: 10.4070/kcj.2012.42.4.288
Loeys-Dietz syndrome is a recently described autosomal dominant disorder caused by mutations in the genes for transforming growth factor-beta receptor type 1 or 2 (TGF-ssR 1/2). The syndrome predisposes patients... -
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- Transforming growth factor beta receptor II polymorphisms are associated with Kawasaki disease
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Choi YM, Shim KS, Yoon KL, Han MY, Cha SH, Kim SK, Jung JH
- KMID: 1433775
- Korean J Pediatr.
- 2012 Jan;55(1):18-23.
- doi: 10.3345/kjp.2012.55.1.18
PURPOSE: Transforming growth factor beta receptor 2 (TGFBR2) is a tumor suppressor gene that plays a role in the differentiation of striated cells and remodeling of coronary arteries. Single nucleotide... -
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- Lower growth factor expression in follicular fluid undergone in-vitro fertilization
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Han M, Park SB, Park BJ
- KMID: 1743677
- Clin Exp Reprod Med.
- 2011 Dec;38(4):210-215.
- doi: 10.5653/cerm.2011.38.4.210
OBJECTIVE: This study was performed to identify whether growth and differentiation factor-9 (GDF-9) and transforming growth factor-beta1 (TGF-beta1) expressions would be lower in the follicular fluid (FF) of those over... -
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- Linear Focal Elastosis Following Striae Distensae: Further Evidence of Keloidal Repair Process in the Pathogenesis of Linear Focal Elastosis
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Jeong JS, Lee JY, Kim MK, Yoon TY
- KMID: 2156774
- Ann Dermatol.
- 2011 Oct;23(Suppl 2):S141-S143.
- doi: 10.5021/ad.2011.23.S2.S141
Linear focal elastosis (LFE) is a rare dermal elastosis characterized by hypertrophic yellowish linear plaques and increased abnormal elastic tissues in the lumbosacral area. Although the pathogenesis of this disorder... -
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- Pro- and anti-inflammatory cytokine expression and histopathological characteristics in canine brain with traumatic brain injury
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Yu CH, Yhee JY, Kim JH, Im KS, Kim NH, Jung DI, Lee HC, Chon SK, Sur JH
- KMID: 1067405
- J Vet Sci.
- 2011 Sep;12(3):299-301.
- doi: 10.4142/jvs.2011.12.3.299
We analyzed the expression level and cellular localization of pro- and anti-inflammatory cytokines and histopathologically characterized canine traumatic brain injury (TBI). Canine TBI brains revealed subarachnoid and cerebral cortical hemorrhage,... -
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