- Enhancing Viability of Human Embryonic Stem Cells during Cryopreservation via RGD-REP-Mediated Activation of FAK/AKT/FoxO3a Signaling Pathway
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Kim JH, Choi JI, Che YH, Sung SH, Lee H, Lee S, Park JH, Lee YI, Lee YS, Jeon WB, Kim YJ
- KMID: 2548533
- Tissue Eng Regen Med.
- 2023 Dec;20(7):1133-1143.
- doi: 10.1007/s13770-023-00568-3
BACKGROUND Cryopreservation is a crucial method for long-term storage and stable allocation of human pluripotent stem cells (hPSCs), which are increasingly being used in various applications. However, preserving hPSCs in... -
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- Computational Analysis of miR-140 and miR-135 as Potential Targets to Develop Combinatorial Therapeutics for Degenerative Tendinopathy
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Morya VK, Lee HW, Park CW, Park CW, Hyun JT, Noh KC
- KMID: 2542327
- Clin Orthop Surg.
- 2023 Jun;15(3):463-476.
- doi: 10.4055/cios22237
Background: Degenerative tendinopathy, a condition causing movement restriction due to high pain, highly impacts productivity and quality of life. The healing process is a complex phenomenon and involves a series... -
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- Vessel-Derived Decellularized Extracellular Matrices (VdECM): Novel Bio-Engineered Materials for the Wound Healing
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Lee CR, Lee YJ, Kwon BY, Lee SJ, Ryu YH, Rhie JW, Moon SH
- KMID: 2539232
- Tissue Eng Regen Med.
- 2023 Feb;20(1):59-67.
- doi: 10.1007/s13770-022-00511-y
BACKGROUND: Decellularized extracellular matrix (dECM) is a non-cellular scaffold with various functions in tissue engineering and regenerative medicine. Elastin is related to tissue elasticity and scarless wound healing, abundantly found... -
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- Anti-Osteoarthritic Effects of Cartilage-Derived Extracellular Matrix in a Rat Osteoarthritis Model
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Lee SH, Jo SH, Kim SH, Kim CS, Park SH
- KMID: 2539234
- Tissue Eng Regen Med.
- 2023 Feb;20(1):83-92.
- doi: 10.1007/s13770-022-00508-7
BACKGROUND: The extracellular matrix (ECM) has many functions, such as segregating tissues, providing support, and regulating intercellular communication. Cartilage-derived ECM (CECM) can be prepared via consecutive processes of chemical decellularization... -
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- Novel Biomarkers of Health and Degeneration in Human Intervertebral Discs: In-depth Proteomic Analysis of Collagen Framework of Fetal, Healthy, Scoliotic, Degenerate, and Herniated Discs
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Rajasekaran S, Soundararajan DCR, Nayagam SM, Tangavel C, Raveendran M, K S SVA, Shetty AP, Kanna RM
- KMID: 2539740
- Asian Spine J.
- 2023 Feb;17(1):17-29.
- doi: 10.31616/asj.2021.0535
Study Design: Profiling proteins expressed in the nucleus pulposus (NP) of intervertebral discs (IVDs) in five different biological states. Purpose: To evaluate the molecular complexity of the collagen (COL) framework and... -
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- Growth plate extracellular matrix defects and short stature in children
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Saltarelli MA, Quarta A, Chiarelli F
- KMID: 2537236
- Ann Pediatr Endocrinol Metab.
- 2022 Dec;27(4):247-255.
- doi: 10.6065/apem.2244120.060
Many etiological factors causing short stature have already been identified in humans. In the last few years, the advent of new techniques for the detection of chromosomal and molecular abnormalities... -
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- Transcriptomic Comparison Analysis between Ameloblastoma and AM-1 Cell Line
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Li S, Lee DJ, Kim HY, Harada H, Jung YS, Jung HS
- KMID: 2536211
- Int J Stem Cells.
- 2022 Nov;15(4):415-421.
- doi: 10.15283/ijsc22132
Cancer initiation and progression are profoundly along with the crosstalk between cancer cells and the surrounding stroma. Accumulating evidence has shown that the therapy targeting the extracellular matrix (ECM) would... -
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- Extra Cellular Matrix Remodeling: An Adjunctive Target for Spinal Cord Injury and Intervertebral Disc Degeneration
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Kumar A, Kumar N, Pathak Z, Kumar H
- KMID: 2533791
- Neurospine.
- 2022 Sep;19(3):632-645.
- doi: 10.14245/ns.2244366.183
The extracellular matrix (ECM) is a protein-and-carbohydrate meshwork that supports a variety of biological structures and processes, from tissue development and elasticity to the preservation of organ structures. ECM composition... -
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- Regions of the human renal artery: histomorphometric analysis
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Mompeó-Corredera B, Hernández-Morera P, Castaño-González I, Quintana-Montesdeoca MdP, Mederos-Real N
- KMID: 2533359
- Anat Cell Biol.
- 2022 Sep;55(3):330-340.
- doi: 10.5115/acb.22.072
The renal artery is frequently involved in the pathogenesis of vasculorenal diseases, and it is a target in kidney surgery and therapeutic techniques for refractory hypertension. However, few detailed structural... -
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- The in vitro analysis of migration and polarity of blastema cells in the extracellular matrix derived from bovine mesenteric in the presence of fibronectin
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Kohannezhad K, Norouzi S, Tafazoli M, Soleymani S, Shahri NM, Tavassoli A
- KMID: 2531209
- Anat Cell Biol.
- 2022 Jun;55(2):229-238.
- doi: 10.5115/acb.21.233
Cell migration is an essential process in embryonic development, wound healing, and pathological conditions. Our knowledge of cell migration is often based on the two dimentional evaluation of cell movement,... -
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- The Progress of Decellularized Scaffold in Stomatology
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Zeng A, Li H, Liu J, Wu M
- KMID: 2530140
- Tissue Eng Regen Med.
- 2022 Jun;19(3):451-461.
- doi: 10.1007/s13770-022-00432-w
The oral and maxillofacial region contains oral organs and facial soft tissues. Due to the complexity of the structures and functions of this region, the repair of related defects is... -
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- M2 Macrophage-Derived Concentrated Conditioned Media Significantly Improves Skin Wound Healing
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Savitri C, Kwon JW, Drobyshava V, Ha SS, Park K
- KMID: 2530152
- Tissue Eng Regen Med.
- 2022 Jun;19(3):617-628.
- doi: 10.1007/s13770-021-00414-4
BACKGROUND: Macrophages, with many different phenotypes play a major role during wound healing process, secreting the cytokines crucial to angiogenesis, cell recruitment and ECM remodeling. Therefore, macrophage-derived cytokines may be... -
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- Engineering the Extracellular Matrix for Organoid Culture
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Heo JH, Kang D, Seo SJ, Jin Y
- KMID: 2526738
- Int J Stem Cells.
- 2022 Feb;15(1):60-69.
- doi: 10.15283/ijsc21190
Organoids show great potential in clinical translational research owing to their intriguing properties to represent a near physiological model for native tissues. However, the dependency of organoid generation on the... -
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- Decorin: a multifunctional proteoglycan involved in oocyte maturation and trophoblast migration
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Park BS, Lee J, Jun JH
- KMID: 2524431
- Clin Exp Reprod Med.
- 2021 Dec;48(4):303-310.
- doi: 10.5653/cerm.2021.05071
Decorin (DCN) is a proteoglycan belonging to the small leucine-rich proteoglycan family. It is composed of a protein core containing leucine repeats with a glycosaminoglycan chain consisting of either chondroitin... -
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- Hypoxia Regulates the Extracellular Matrix via Mitogen-Activated Protein Kinases Pathway in Cells Retrieved from the Human Intervertebral Disc
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Kang YM, Shin EJ, Lee BH, Yang JH, Lee HM, Moon SH
- KMID: 2518571
- Yonsei Med J.
- 2021 Aug;62(8):734-742.
- doi: 10.3349/ymj.2021.62.8.734
Purpose: The present study aimed to identify the physiological characteristics of cells by investigating the change in gene expression and protein levels during extracellular matrix (ECM) synthesis in the intervertebral... -
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- MicroRNA-139-5p Regulates Fibrotic Potentials via Modulation of Collagen Type 1 and Phosphorylated p38 MAPK in Uterine Leiomyoma
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Ahn SH, Kim H, Lee I, Lee JH, Cho S, Choi YS
- KMID: 2518570
- Yonsei Med J.
- 2021 Aug;62(8):726-733.
- doi: 10.3349/ymj.2021.62.8.726
Purpose: This study aimed to elucidate whether microRNA-139-5p is involved in the pathogenesis of uterine leiomyoma. Materials and Methods: Human leiomyoma and matched human smooth muscle samples were obtained from 10... -
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- Anti-fibrotic treatments for chronic liver diseases: The present and the future
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Odagiri N, Matsubara T, Sato-Matsubara M, Fujii H, Enomoto M, Kawada N
- KMID: 2517624
- Clin Mol Hepatol.
- 2021 Jul;27(3):413-424.
- doi: 10.3350/cmh.2020.0187
Liver fibrosis reflects tissue scarring in the liver due to the accumulation of excessive extracellular matrix in response to chronically persistent liver injury. Hepatocyte cell death can trigger capillarization of... -
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- Irreversible Bladder Remodeling Induced by Fibrosis
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Kim SJ, Kim J, Na YG, Kim KH
- KMID: 2516587
- Int Neurourol J.
- 2021 May;25(Suppl 1):S3-7.
- doi: 10.5213/inj.2142174.087
Underactive bladder and impaired bladder compliance are irreversible problems associated with bladder fibrosis. Remodeling of the extracellular matrix is regarded as an important mechanism associated with bladder fibrosis. However, various... -
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- Change of Extracellular Matrix of Human Vocal Fold Fibroblasts by Vibratory Stimulation
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Kim JM, Shin SC, Kwon HK, Cheon YI, Ro JH, Lee BJ
- KMID: 2515638
- J Korean Soc Laryngol Phoniatr Logoped.
- 2021 Apr;32(1):15-23.
- doi: 10.22469/jkslp.2021.32.1.15
Background and Objectives During speech, the vocal folds oscillate at frequencies ranging from 100–200 Hz with amplitudes of a few millimeters. Mechanical stimulation is an essential factor which affects metabolism... -
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- Treatment Response Evaluation of Cardiac Amyloidosis Using Serial T1- and T2-Mapping Cardiovascular Magnetic Resonance Imaging
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Son J, Hong YJ
- KMID: 2514737
- J Korean Soc Radiol.
- 2021 Mar;82(2):429-434.
- doi: 10.3348/jksr.2020.0048
Amyloidosis is a multisystemic disease characterized by the accumulation of abnormal proteins in extracellular spaces in various organs, with frequent involvement of the myocardium. We report a case of a... -
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